Nearly half of cancer patients experience pain, which can show up in various ways. It may be short-lived or long-lasting, mild or severe, or even affect one or a few organs and bones. Since your pain is unique, we tailor treatment plans for cancer pain management to address your needs.
Causes of Pain
- Pain from the tumor: Most cancer pain occurs when a tumor presses on bone, nerves or organs. The pain may vary according to location. For example, a small tumor near a nerve or the spinal cord may be very painful, while a larger tumor elsewhere may not cause discomfort.
- Treatment-related pain: Chemotherapy, radiotherapy and surgery can cause pain. Also, certain painful conditions are more likely to occur in patients with a suppressed immune system, which is often a result of these therapies.
- Post-operative pain: Relieving pain resulting from surgery helps people recuperate more quickly and heal more effectively.
Cancer pain is very treatable. About nine out of 10 cancer pain patients find relief using a combination of medications. Many medicines are used for cancer pain management. Some drugs are general pain relievers, while others target specific types of pain and may require a prescription.
Mild to moderate pain
Non-opioids: Examples are acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin and ibuprofen. Most non-opioids can be purchased over-the-counter without a prescription.
Moderate to severe pain
Opioids: Examples are morphine, hydromorphone, oxycodone, hydrocodone, codeine, fentanyl and methadone.
Tingling & burning pain
Antidepressants: Examples are amitriptyline, imipramine, doxepin and trazodone. Taking an antidepressant does not mean that you are depressed or have a mental illness.
Antiepileptics: An example is gabapentin. Taking an antiepileptic does not mean that you are going to have seizures.
Pain caused by swelling
Steroids: Examples are prednisone and dexamethasone.
How Pain Medicine Is Taken
Most pain medicine is taken by mouth either in pill or liquid form. Oral medications are easy to take and usually cost less than other kinds of medicine. Other methods for administering pain drugs include:
- Rectal suppositories
- Transdermal patches
- Subcutaneous - medicine is placed just under the skin using a small needle
- Subdermal and intramuscular - injections are placed more deeply into the skin or muscle; not recommended for long-term cancer pain treatment
- Intravenous - medicine is placed directly into a vein through a needle that stays in the vein, allowing patients to adjust how much medicine they receive
- Epidural or intrathecal - medicine is placed directly into the spine using a small tube, providing relief for several hours
Non-Drug Pain Treatment Options
Your doctor or nurse may recommend non-drug treatments for managing your cancer pain in addition to your pain medication. These treatments will help your medicines work better and relieve other symptoms, but they should not be used instead of medication.
- Biofeedback: A technique that makes the patient aware of bodily processes normally thought to be involuntary (blood pressure, skin temperature and heart rate). Patients can gain some conscious voluntary control of these processes, which can influence their level of pain.
- Breathing and relaxation exercises: These methods focus the patient’s attention on performing a specific task, instead of concentrating on the pain.
- Distraction: A method used to shift attention to a more pleasant event, object or situation
- Heat or cold: Using temperature to facilitate pain control with packs or heating pads
- Hypnosis: A focused state of consciousness that allows the patient to better process information
- Imagery: Using soothing, positive mental images that allow the patient to relax
- Massage, pressure and vibration: Physical stimulation of muscles or nerves can assist with relaxation and relieve painful muscle spasms or contractions.
- Transcutaneous electrical nerve stimulation (TENS): A mild electric current is applied to the skin at the site of the pain.
When Medicine Is Not Enough
You may have pain that is not relieved by medicine. If so, consider these methods to reduce pain:
Radiation therapy: This treatment reduces pain by shrinking a tumor. A single dose of radiation may be effective for some people.
Nerve blocks/implanted pump: Certain nerve blocks, temporary or permanent, may help relieve some painful conditions. Implanted pain pumps can also provide relief in some patients.
Neurosurgery: Nerves (usually in the spinal cord) are cut to relieve the pain.
Surgery: When a tumor is pressing on nerves or other body parts, operations to remove all or part of the tumor can relieve pain.
Many types of cancers can spread to the bone, leading to areas of damage called lesions. 80% of patients with metastatic prostate cancer develop bone lesions, but it’s also common in patients with many other types of cancer including metastatic breast cancer and metastatic renal cell carcinoma. These lesions leave patients in pain and sometimes impact mobility. They’re most commonly found in the ribs, the pelvis and the spine. Bone metastases occasionally occur in the shoulders and legs.
Usually, chemotherapy or immunotherapy can treat a bone lesion, and radiation therapy and pain medicine help manage their associated cancer pain. But these traditional methods don’t always work or aren’t an option for all patients.
MD Anderson is leading a new approach for patients with bone metastases that uses interventional radiology. These techniques offer patients a new option for pain management that can provide fast relief with few side effects. Interventional radiologist Rahul Sheth, M.D., shares how these minimally invasive procedures are changing the way we manage cancer bone pain.
What is interventional radiology?
Interventional radiology combines diagnostic imaging techniques like X-rays or CT scans with therapeutic procedures done inside the body. The procedures are performed through small pinholes in the skin and can help address a variety of medical concerns – not just cancer. The diagnostic imaging tools allow us to take pictures in real-time during the procedure. That way, we know exactly where everything is at all times without having to make a big incision to open the patient up.
Instead, patients receive small punctures, similar to needles through the skin. And, there are no stitches afterward. We essentially put a Band-Aid on top while the punctures heal over the next couple of days.
For patients with bone metastases, interventional radiology can provide a real benefit in managing pain. Although each patient is different, most people go home the same day or the next day, and they feel relief a few days after the procedure.
Reasons for cancer bone pain
Bone tumor-related pain can be caused by one or a combination of
three things. The first is the cancer cells themselves. When the
tumor’s cells take root inside the bone, their presence releases
inflammatory proteins, which cause local inflammation.
The brain perceives that inflammation as pain.
Second, as the cancer cells erode the bone, they can cause inflammation at the lining of the bone, which is where nerve fibers are found. As the tumor grows and the lining of the bone stretches, and the tumor can break out of the bone and cause pain.
Lastly, if the tumor is on a weight-bearing bone like the spine or the pelvis, it can cause pain. It’s just like when you break your wrist: There are fractures in the bone, and the fragments move around. As you move, the fragments rub against each other and can’t heal. This leads to inflammation that causes pain.
With interventional radiology, we tailor our treatment approach to address which of these three – or all three – are causing the pain.
When pain medicine and radiation therapy are n’t an option, interventional radiology may be
Even when prescribed at a high dosage, an opioid may not relieve bone cancer pain for a patient. Interventional radiology procedures can help wean patients off opioids while offering long-term pain relief.
Radiation therapy is another common approach for addressing pain, but it’s not an option for everyone. If a patient has already received radiation in that area, this treatment can’t typically be used again. But another benefit of interventional radiology is that the procedures can be repeated. Also, if a patient is receiving chemotherapy, they may have to pause the drugs to schedule radiation therapy. If the cancer is aggressive, this could be an issue. Interventional radiology is conveniently combined with other treatments since the procedures and recovery are quick.
Some cancer types are known to be resistant to radiation therapy. In those cases, we try to be more aggressive with treatment. At MD Anderson, we’re conducting a clinical trial that’s investigating stereotactic body radiation therapy combined with interventional radiology techniques. Our goal is to speed up how soon patients feel relief and maximize how long that relief lasts.
Interventional radiology helps destroy a bone tumor
The best way to address pain directly caused by a tumor on the bone is to eliminate the tumor. Two interventional radiology approaches we commonly use are ablation and embolization.
- Ablation: We destroy a tumor by subjecting it to extreme temperatures – either hot or cold. We insert a needle through the skin and into the tumor. That needle generates heat at its tip to heat the tumor, or it freezes the tumor into a ball of ice. We monitor the size of the ice ball with imaging techniques. This allows us to ensure we’re treating the entire tumor and avoiding surrounding normal tissue. At MD Anderson, we’re also exploring using ablation to improve systemic cancer treatments like immunotherapy.
- Embolization: By working with a patient’s blood vessels, we can destroy a tumor. Like the way cardiologists place stents in the blood vessels supplying blood to the heart, we do the same thing to the blood vessels supplying blood to a tumor. We enter the body, often through the leg or the wrist, and navigate to the tumor inch by inch, using X-rays to follow along. Next, we pack the blood vessels with thousands of microscopic plastic beads that float deep into the tumor and block the blood flow. This cuts off oxygen and nutrients and leads to the tumor’s death.
We often combine these techniques to maximize their benefit.
Bone cement stabilizes the bone to relieve pain
If the pain is caused by a tumor destroying the bone, we have a different approach. Much like a cast helps hold together broken bone so that it can heal, we do the same thing on the inside with bone cement. We glue together the bone fragments to hold them in place and speed up healing. The cement stops the constant motion of the fractured bone, and the patient feels relief soon after the procedure. In our recovery area, patients often already start to feel improvement in their pain levels.
This pain is a huge quality of life factor for our patients, and it’s gone within a few hours, thanks to these approaches. Personally, it's very fulfilling and rewarding work.
Request an appointment at MD Anderson online or by calling 1-877-632-6789.
Due to our response to COVID-19, all blood donations at MD Anderson
Blood Donor Center locations are being held by appointment only.