Overcoming resistance to available treatments
For some prostate cancer patients, hormone therapy cannot prevent the cancer from spreading to other parts of the body. Currently, there is little to offer patients with treatment-resistant disease. To rectify this, our Moon Shot team is investigating the mechanisms that drive disease progression and resistance to hormone therapy in patients with castration resistant prostate cancer (CRPC). This new knowledge will guide our efforts to identify biological pathways that can be targeted through new forms of therapeutic intervention and help identify combinations of previously validated therapies.