Skin Cancer

Skin cancer can affect people of all skin tones. It develops when the cells of your outermost layer of skin, called the epidermis, grow uncontrollably. The epidermis is primarily composed of three types of cells -- squamous cells, basal cells, and melanocytes. The type of cancer depends on the layer in which it starts.

The three most common types of skin cancer are:

Basal cell carcinoma: Basal cell carcinoma is the most common type of skin cancer. It originates in the basal layer of your epidermis, from which new skin skin cells grow. Basal cell skin cancers are slow growing and seldom spread, but they can invade and destroy underlying tissues and bone if left untreated. Read more about basal cell carcinoma.

Squamous cell carcinoma of the skin: Squamous cell carcinoma of the skin is the second most common type of skin cancer. It originates in your squamous cells, which make up most of your epidermis. It can grow more rapidly than basal cell carcinoma and is more likely to metastasize. It is also more likely to invade and destroy underlying bone and muscle if not treated. However, most cases are not life threatening. Read more about squamous cell carcinoma of the skin.

Melanoma: Melanoma is cancer that begins in the cells that produce skin pigment. It is less common than basal or squamous cell skin cancers, but it is more dangerous and can be deadly. If caught early, there is nearly a 97% chance for cure. Read more about melanoma.

Additional, rare skin cancers include:

• Kaposi sarcoma, a rare skin cancer characterized by the presence of purple, red or brown lesions on the skin. It is caused by a virus and tends to affect people with suppressed immune systems.
• Merkel cell carcinoma, which appears as red, shiny nodules on the face, hands and neck
• Sebaceous gland carcinoma, a rare form of cancer that begins in the sweat or oil glands of your skin

This page focuses on basal cell carcinoma and squamous cell carcinoma, which are sometimes referred to as non-melanoma skin cancer. When found early, most cases of non-melanoma skin cancers are curable.

Melanoma is more aggressive than non-melanoma skin cancers and is treated differently. More information on melanoma can be found on our melanoma disease page.

Skin cancer risk factors

Anything that increases your odds of developing skin cancer is a risk factor.

Skin cancer risk factors include:

• Ultraviolet light (UV radiation): Extensive lifetime sun exposure or occasional intense exposure, especially without sunscreen
• Living at a high altitude or in a sunny climate
• A history of sunburns
• Tanning bed use
• Age: Sun exposure increases with age, and older patients tend to be at higher risk
• Having a fair complexion, blond or red hair, freckles, blue eyes and/or a tendency to sunburn.
• Being immunocompromised, typically due to taking immunosuppressive drugs.
• Family history of skin cancer
• Having many moles, especially abnormal moles that are large or have an irregular shape (dysplastic nevi)
• A personal history of skin cancer: Having skin cancer once puts you at higher risk for developing skin cancer again
• Certain rare genetic disorders, including xeroderma pigmentosum and basal cell nevus syndrome.
• Previous serious skin injuries, such as a major scar or burn.
• Actinic (solar) keratosis. This is a precancerous lesion that may appear as rough, red and scaly patches on the skin. It may be tender and is often more easily felt than seen. Like skin cancer, actinic keratosis usually is found on sun-exposed areas of the body. About 5% develop into a non-melanoma skin cancer.

Not everyone with risk factors gets skin cancer. However, if you have risk factors, it’s a good idea to discuss them with your health care provider.

Learn more about skin cancer:

• Skin cancer symptoms
• Skin cancer diagnosis
• Skin cancer treatment
  

Some people have an elevated risk of developing skin cancer. Review the skin cancer screening guidelines  to see if you need to be tested.  

Behavioral and lifestyle changes can help prevent skin cancer. Visit our prevention and screening section to learn how to manage your risk.

In rare cases, skin cancer can be passed down from one generation to the next. Genetic counseling may be right for you. Visit our genetic testing page to learn more.

Why choose MD Anderson for skin cancer treatment?

At MD Anderson’s Ben Love/El Paso Corporation Melanoma and Skin Center, your skin cancer treatment is personalized to provide the most advanced therapies with the best outcomes and fewest side effects.

Our skin cancer program is one of the largest in the nation. This gives us a level of experience and expertise found in few other centers.

Renowned experts from multiple disciplines work together to customize your care. Beginning with the most accurate diagnosis possible, we offer comprehensive, specialized care for every type of skin cancer.

We're constantly researching newer, safer, and more effective ways to prevent, diagnose and treat skin cancer. This allows us to offer the best possible treatment at any point in your skin cancer care, ranging from established therapies to new interventions.