The MD Anderson Symptom Inventory (MDASI) is a multi-symptom patient-reported outcome (PRO) measure for clinical and research use. Use the MDASI to assess the severity of symptoms experienced by patients with cancer and the interference with daily living caused by these symptoms.
The MDASI’s 13 core symptom items are those found to have the highest frequency and/or severity in patients with various cancers and treatment types. The MDASI has several advantages over other symptom-assessment scales:
- It assesses both symptom severity and symptom interference with daily life
- It applies broadly across cancer types and treatments
- It can be adapted to specific cancer types, sites, and treatments (MDASI modules)
- Its 0-10 scale is easy for patients to understand and complete
- It is easily translated into other languages
The MDASI is available in paper-and-pencil, electronic, and telephone-based interactive voice response (IVR) formats, all of which are equally effective. A recent report at the American Society of Clinical Oncology (ASCO) 2017 Annual Meeting showed that assessing symptoms in real time and alerting clinicians when symptoms worsen or become severe—as can be done with electronic methods such as web-based patient portals and IVR systems—improved quality of life, enhanced treatment tolerance, reduced the number of emergency room visits and lengthened survival even better than some cancer therapies did.
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The MDASI User's Guide
In response to the FDA's 2009 guidance for the pharmaceutical industry on the use of PRO measures in medical product development to support labeling claims, we have prepared a MDASI User's Guide to document the development and psychometric properties of the MDASI and its modules. The User Guide addresses the recommendations in the FDA guidance and establishes the MDASI's adequacy as a measure to support medical product claims.
We are developing brief ‘fit-for-purpose’ patient-reported outcomes questionnaires that capture a patient's symptoms, their severity and their interference with functioning and quality of life.
Charles S. Cleeland, Ph.D.
Professor, Symptom Research
MDASI modules augment the 19 core MDASI symptom and interference items with additional symptoms that are unique to a particular patient population.
- Purpose: To assess the severity of multiple symptoms and the impact of symptoms on daily functioning
- Population: Patients with symptoms caused by cancer and cancer treatment
- Assessment areas: Severity of multiple symptoms and the impact of symptoms on daily functioning during the last 24 hours
- Method: Self-report, interview or via telephone-based interactive voice response (IVR) system
- Time required: Five minutes (less for electronic administration)
- Scoring: Please see the MDASI User's Guide
- Reliability: Cronbach alpha reliability ranges from 0.82 to 0.94
The MDASI is available in paper-and-pencil, electronic, and telephone-based interactive voice response (IVR) formats, all of which are equally effective. Electronic MDASI data capture offers several benefits:
- Allows symptoms to be monitored when the patient is away from the hospital
- Is convenient for patients, who may use their choice of web access, personalized patient portals, or smart phones to access questionnaires
- Minimizes missing data, especially in longitudinal studies
- Provides more accurate, real-time symptom data at expected time points
- The availability of immediate feedback could allow caregivers to address severe symptoms more effectively.
Click on a linked language to view a sample in PDF format.
Don't see a language you need? Contact us at email@example.com.
|Psychometrically and Linguistically Validated||Linguistically Validated|
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