Breast Cancer Moon Shot Update
MOON SHOTS PROGRAM
Help end breast cancer
Every year in the U.S., approximately 235,000 men and women are
diagnosed with breast cancer and more than 40,000 succumb to it.
Nearly 69,000 patients have the subtype known as triple-negative
breast cancer (TNBC), which causes almost 12,000 deaths annually. The
Breast Cancer Moon Shot™ is determined to defeat this deadly type of
Finding the right target
A flood of new knowledge and technology makes now the time to fast-track the cancer fight and make a giant leap for patients. We're merging today’s high potential for achievement with our unique knowledge and expertise, derived from decades of leadership in the cancer field.
Most successful treatments for breast cancer take aim at specific proteins expressed by individual tumors: estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 (HER2). But TNBC doesn’t express any of these biomarkers, so there’s no current option for targeted therapy. This limits treatment mainly to surgery and chemotherapy, which are less effective against TNBC. Even if caught early, TNBC has an overall five-year survival of 60% compared to 80% for other types. To improve patient outcomes, we’re researching novel genetic markers to identify new plans of attack.
Gifts to this research program will help increase our biological understanding of TNBC and allow us to identify and develop new targeted therapies, plus strategies for prevention and early detection. Our goal is to offer the most personalized course of therapy possible, optimized to match — and defeat — each patient’s tumor at the molecular level.
Breast Cancer Moon Shot Leaders
Junjie Chen, Ph.D.
Chair, Experimental Radiation Oncology
Stacy Moulder, M.D.
Associate Professor, Breast Surgical Oncology
STORIES OF HOPE
Delia’s hope for all TNBC patients
Delia battled stage 3 triple-negative breast cancer and came through strong. Her medical team worked on a novel treatment option that incorporates carboplatin, a new drug in the standard chemo regimen, and reverses the order in which drugs are given to minimize unwanted side effects. Delia is hopeful for the future and confident that through The Moon Shots Program™, MD Anderson will find a successful targeted treatment for TNBC and end the waiting game for future cancer patients.
TNBC trials by Moulder
In the era of targeted therapy, the inefficiency of treating triple-negative breast cancer (TNBC) can be particularly frustrating. Chemotherapy works for half of patients, but they can’t be identified in advance, and other promising drugs seemed to have little effect in general clinical trials.
So the Breast Cancer Moon Shot has launched a clinical trial platform to personalize treatment for the aggressive breast cancer that’s best known for what it doesn’t have – three targets for precision medicine that have helped extend survival of other breast cancer patients. By analyzing biopsies, they’re guiding patients to clinical trials of drugs most likely to hit their tumor’s target.
An important mission
The Breast Cancer Moon Shot is leading several new and exciting projects that can quickly make a difference in the detection and treatment of breast cancer.
Get comprehensive information about the facts, symptoms, diagnosis,
and treatment of breast cancer.