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- Appendix Cancer
- Appendix Cancer Treatment
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As one of the nation’s top ranked cancer centers, we see more patients with this complex type of cancer than most others. This gives us an extraordinary level of expertise and experience.
Our renowned surgeons are among the most recognized in the country and perform more appendix cancer procedures in a year than many cancer surgeons do in a lifetime. Our medical oncology team specializes in formulating individualized treatment plans using state-of-the-art systemic treatments and targeted therapies, along with clinical trials.
If you are diagnosed with appendix cancer, your doctor will discuss the best options to treat it. This depends on several factors, including:
- The type of tumor
- Where it is in the appendix
- If it has spread
- Your overall health
Your treatment for appendix cancer will be customized to your particular needs. One or more of the following therapies may be recommended to treat the cancer or help relieve symptoms.
Surgery
Surgery is the main treatment for appendix cancer. The type of surgery depends on the type of appendix cancer.
Neuroendocrine tumors (NETs): Often a surgery called a right hemicolectomy is done to remove the appendix, right colon and surrounding lymph nodes. If the tumor has not spread, surgery alone may be enough treatment. For more information, see neuroendocrine tumors.
Adenocarcinoma tumors: Treatment may include all of the following:
- Removal of the right part of the colon
- Cytoreductive surgery with HIPEC
- Chemotherapy before surgery
Pseudomyxoma peritonei (PMP): Surgical removal of the tumor (also called cytoreduction), combined with HIPEC, is usually recommended.
In some cases, surgery may be combined with chemotherapy, which uses specific drugs to attack fast-growing tumor cells.
If appendix cancer has spread within the abdomen, the most effective approach usually involves cytoreductive (tumor debulking) surgery to remove the tumor and mucin in the abdomen. Parts of the intestine, gallbladder, ovaries, uterus and lining of the abdominal cavity may be removed.
Hyperthermic intraperitoneal chemotherapy (HIPEC), also known as heated chemotherapy, is performed during tumor debulking surgery. The abdominal cavity is filled with a chemotherapy drug that is heated to more than 104 degrees Fahrenheit. The abdomen is rocked gently back and forth for 90 minutes to ensure the drugs go to all areas of the abdominal cavity. This allows the chemotherapy drugs to reach tumor cells that the surgeon may not be able to see.
Chemotherapy
Chemotherapy drugs kill cancer cells, control their growth or relieve disease-related symptoms. Chemotherapy may involve a single drug or a combination of two or more drugs, depending on the type of cancer and how fast it is growing.
The medical and surgical oncology care teams will collaborate to determine the right type of chemotherapy for each patient.
Learn more about chemotherapy.
Clinical trials
MD Anderson offers a diverse group of clinical trials to serve the needs of our appendix cancer patients who have limited treatment options. Your care team may recommend clinical trials if appropriate. Genetic profiling is offered to patients to determine which clinical trials may benefit them.
Learn more about clinical trials.
Learn more about appendix cancer:
Treatment at MD Anderson
Appendix cancer is treated in our Gastrointestinal Center.
Clinical Trials
MD Anderson patients have access to clinical trials offering promising new treatments that cannot be
found anywhere else.
Teen appendix cancer diagnosis leads family back to MD Anderson
When Angie Levinthal’s husband, Jared was diagnosed with colon cancer in 2012, she was terrified that he might not be there to watch their three daughters grow up.
A decade later, the couple learned that one of their daughters now had an appendiceal neuroendocrine tumor, a type of appendix cancer.
Angie was furious. She couldn’t believe her family had to hear those words again, and she couldn’t bear the idea of 17-year-old Kendall suffering.
The family sought the care and expertise that had helped Jared overcome cancer. They came to MD Anderson for a second opinion.
“After facing cancer before, there was nowhere our family would go but MD Anderson,” Angie says.
Facing an appendix cancer diagnosis
When it came to her health, it seemed like Kendall never got a break, Angie says. At 9 months old, she’d had surgery to have a part of a kidney removed after complications at birth. Later, she had her adenoids removed and four surgeries for ear tubes. At 9, she suffered permanent hearing damage. But she never let the struggles get the better of her. It motivated her. She plans to study speech pathology in college and use her experiences to help others.
Kendall’s appendix cancer symptoms began in March 2022, when she had dull stomach pain and a low-grade fever. It reminded Angie of the symptoms she had suffered years prior when she’d had appendicitis. The pediatrician confirmed Kendall would need emergency surgery to remove her appendix right away.
The surgery went smoothly and Kendall went home to recover the next day. But the surgeon told Angie that he had noticed an unusual spot on Kendall’s appendix during the procedure. It was probably nothing, but he’d performed a biopsy just to be sure. The next day he called with the biopsy results. Kendall had an appendiceal neuroendocrine tumor. While cancerous, this type of tumor usually behaves like a benign tumor. They’re rare in general and even more rare in teenage girls. Because the tumor had been removed along with Kendall’s appendix, she wouldn’t need additional treatment.
Remembering Jared’s colon cancer treatment
The diagnosis immediately brought back memories of Jared’s stage IV colon cancer diagnosis. There had been a less than 10% chance that he would live. He had two surgeries and six rounds of chemotherapy. The couple considers that time the hardest time of their lives. Fortunately, Jared was declared cancer-free and has remained so ever since then.
“We’re so grateful we came to MD Anderson. We sought their expertise because Jared’s dad had been treated for stage IV melanoma there years before and had such an amazing experience and positive outcome,” Angie says.
The couple wanted to turn to MD Anderson again, but first, they had to tell Kendall. They decided Jared should keep his distance. They didn’t want her to have such a clear reminder of how difficult cancer treatment could be in the room when she heard the news. So, Angie sat down with her daughter and shared the results of the pathology report. Kendall was scared, but like everything she had ever faced, she took it in stride. Kendall knew she could look to her dad for inspiration. For him, the cancer was in the past, and she knew soon it would be for her, too.
She agreed with her parents. They needed a second opinion from MD Anderson.
Undergoing surgery at MD Anderson
At MD Anderson, the Levinthals met with surgeons Christopher Scally, M.D., and Matthew Tillman, M.D. They explained that it was OK to watch and wait, as the first surgeon had suggested, but a safer option that would give the family more peace of mind would be to do exploratory surgery on Kendall’s colon to make sure none of the cancer remained. Because Kendall had a rare inherited condition called intestinal malrotation and her intestines didn’t form into a coil, her operation would be more complex than usual, but her surgical team had a plan.
They would perform a minimally invasive procedure using a robot that would allow the surgeons to make small incisions. Kendall would only have small scars and would be back to an active lifestyle and hanging out with her friends in a matter of weeks.
Not a trace of cancer was found during the surgery. Kendall spent two nights in the hospital. She was the youngest person on the inpatient floor, but her care team never made her feel like she was out of the ordinary. Knowing that a cancer treatment surgery can be a little extra lonely for a teen, the nurses went out of their way to take time to visit with her until she was ready to go home.
After recovering at home for 10 days, Kendall felt well enough to attend a pool party with her friends, and her abdomen had healed so quickly that she was even able to wear her two-piece swimsuit — normalcy the teenage girl was grateful for.
Angie also consulted with a genetic counselor at MD Anderson, who assured her Jared and Kendall’s cancers weren’t related genetically.
Moving forward
Kendall will undergo check-ups at MD Anderson every six months. She has an excellent prognosis and her surgeons say her chances of recurrence are low. She’s glad to be able to be cancer behind her and focus on the start of her freshman year of college at The University of Texas this fall.
Her family is grateful for the hospital that helped her family overcome cancer, not once, not twice, but three times.
Request an appointment at MD Anderson online or by calling 1-877-632-6789.
Stage IV appendix cancer survivor: Why I got my HIPEC surgery at MD Anderson
The year I turned 50, my life took an unexpected turn. First, I had to have emergency surgery after a CT scan for severe abdominal pain revealed what appeared to be late-stage ovarian cancer.
Next, I found out it was a rare type of appendix cancer called low-grade appendiceal mucinous neoplasm (LAMN), and that it had already spread to my ovaries.
Finally, I learned that the only real treatment for it — aside from surgically removing all visible traces of it — was hyperthermic intraperitoneal chemotherapy (HIPEC).
Before that day, I don’t think I even realized that appendix cancer could be a thing. I’d certainly never heard of HIPEC. But when I found out it was a complicated surgery that involves filling the abdominal cavity with heated chemotherapy and then kind of swishing it around, I knew I needed to get treated someplace with a lot of experience.
Why regular chemotherapy wouldn’t work for me
I asked my local doctor in Mississippi why I couldn’t just do regular chemotherapy. Frankly, HIPEC sounded like something out of a science fiction movie.
My surgeon explained that this type of appendix cancer spreads through a gelatinous substance that seeps between the organs. She’d already removed about a liter of it from my abdominal cavity during the emergency surgery, along with my appendix, uterus, ovaries and some of my colon.
The cancer had been on my organs, my oncologist added, not in them. So, traditional chemo wouldn’t do any good. That’s why HIPEC really was the best — and only — option.
MD Anderson’s expertise gave me confidence
I was surprised to learn just how unusual this type of appendix cancer is. It only affects about 1 or 2 people per million each year. With something this rare, I knew it was important to seek out the experts. I called MD Anderson.
I’d already read on MD Anderson’s website that its doctors perform more than 100 HIPEC surgeries each year. Once I met with surgical oncologist Dr. Keith Fournier, though, I felt even more comfortable. He looked at my scans, explained the process and said he felt very confident he could do it.
Dr. Fournier made this unusual procedure seem like something routine. He didn’t seem worried about it at all. And, he’s an expert in both this disease AND this procedure. That made me not worry about it.
Looking to the future with optimism
Dr. Fournier performed my HIPEC surgery on Nov. 22, 2024. It took about 11 hours because he also removed my gall bladder, spleen, peritoneal lining and a little more of my colon. I spent 10 days in the hospital recovering.
It’s been seven months now since my surgery, and I feel so much better. I was really tired when I first left the hospital, though. I remember thinking, “Is it always going to be like this?” I was sleeping so much that I started worrying it was abnormal. But nine weeks later, my energy was back up, and I was able to return to work as a middle school English Language Arts coach.
I’ll need to have scans every six months for a couple of years to make sure the cancer hasn’t returned, and then yearly after that. My next scan is in June, and I hope to show no evidence of disease. But every day, I feel a little better. So, I am optimistic about the future.
That’s why I tell everyone to go to MD Anderson. When you first hear the word “cancer,” call MD Anderson. It runs like a well-oiled machine. And everyone there is so knowledgeable.
Request an appointment at MD Anderson online or call 1-877-632-6789.
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