Romero Laboratory
Rodrigo Romero, Ph.D.
Principal Investigator
Areas of Research
- Animal Models
- Cancer Biology
- Cancer Stem Cells
- Carcinoid Tumor
- Chromatin
- CRISPR Screens
- Epigenetics
- Epithelial Biology
- Evolution and Development
- Gene Expression
- Genetics Functional Screen
- Genetics
- Immunotherapy
- Lung Cancer
- Molecular Biology
- Mouse Model Development
- Prostate Cancer
- Targeted Therapy
- Tumor Heterogeneity
- Tumor Microenvironment
Welcome to the Romero Laboratory. We study how cancer cells change their cellular state during disease progression to resist therapy. By integrating next-generation genetically engineered mouse and organoid models with functional genetics, single-cell and spatial methodologies, our goal is to uncover the causal mechanisms that drive lineage plasticity and to identify strategies to prevent or reverse aggressive tumor states.
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- Departments, Labs and Institutes
- Labs
- Romero Laboratory
Research Focus
Lineage plasticity enables cancer cells to evade therapy by engaging alternative developmental programs and adopting new cellular identities. This process underlies the emergence of aggressive disease states such as neuroendocrine prostate cancer and small cell lung cancer. The overall goal of our laboratory is to define how disruptions in chromatin regulation and tumor suppressor pathways destabilize cell identity and drive lineage plasticity in cancer.
Related Departments and Programs
Related Facilities
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Advanced Technology Genomics Core (ATGC)
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CYTOGENETICS AND CELL AUTHENTICATION CORE (CCAC)
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GENETICALLY ENGINEERED MOUSE FACILITY (GEMF)
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Flow Cytometry and Cell Imaging Facility (FCCIF)
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Small Animal Imaging Facility (SAIF)
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Advanced Spatial Genomics Core (ASGC)
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Epigenomics Profiling Core (EPC)
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Functional Genomics Core (FGC)
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Research Areas
Find out about the four types of research taking place at UT MD Anderson.