Neurosurgery Research
The Neurosurgery department has developed a world-class clinical program to manage all aspects of neurosurgical oncology, including complex brain and skull base tumors, spinal tumors, and intractable, cancer-related pain disorders. We work to discover new imaging and surgical techniques and methods to effectively treat and manage pain. The goal of our research is to improve survival rates and quality of life for our patients.
In addition, we have exceptional basic and applied research programs. Our researchers investigate such topics as immune suppression therapies for malignant gliomas, gene and stem cell therapies for brain and spine tumors, molecular mechanisms, and various aspects of cancer metastasis. We have employed researchers that are recognized for their expertise in the areas implicated in tumor development and progression. The objective is to effectively move therapies from bench to bedside, and our researchers collaborate closely with physicians to integrate laboratory discoveries with clinical observations.
Brain Tumor Research Program
The Brain Tumor Research Program (within the Brain Tumor Center) is a multidisciplinary program that promotes collaborations among its members for laboratory and clinical research, and treatment strategies for brain, skull base and spinal tumors. This program spans 22 departments and involves more than 100 research and clinical scientists who focus on discovering the molecular changes that drive brain and spinal tumors and developing effective new treatments for these devastating tumors. The Brain Tumor Research Program supports interactions among its diverse group by sponsoring scientific retreats, meetings, training opportunities and collaborative projects.
Glioblastoma Moon Shot®
Glioblastoma Moon Shot
The Glioblastoma Moon Shot® is conducting impactful research in the lab and clinic to improve the lives of patients with CNS tumors.
Glioblastoma is the most common primary brain tumor in adults and the most frequent solid tumor in children. These aggressive tumors can occur in any lobe of the brain, but most commonly occur in the frontal and temporal lobes. While they don't metastasize outside of the brain, they are very infiltrative and spread into other parts of the brain quickly.
Current treatments for glioblastoma are few in number and short on effectiveness, but the Glioblastoma Moon Shot® is working to change that with a passionate, multidisciplinary team of experts who have helped shape the field. Through coordinated laboratory and clinical research, the Moon Shot is finding new vulnerabilities, testing new therapies and implementing better treatment approaches in the clinic to improve the lives of patients.
Central Nervous System Tumor Analysis STream “CATALYST”
The MD Anderson Central Nervous System Tumor Analysis STream “CATALYST” is a streamlined, multi-departmental biospecimen collection and analysis pipeline that comprehensively analyzes and integrates data from every available
neurosurgical patient at MD Anderson.
CATALYST is not only unique, but highly innovative as it enhances biospecimen-based research, empowering multiple investigational initiatives toward a comprehensive assessment of primary and recurrent nervous system tumors, with the inclusion of matched blood, cerebrospinal fluid, and stool specimens. Funded by the highly successful MD Anderson Moon Shots® Program, this effort is unique to MD Anderson, where we see more rare tumors than any other cancer center in the world.
Main goals of CATALYST:
- Define signatures of brain tumors through genetic and epigenetic profiling.
- Better understand the limited activity of immunotherapy in brain tumors through detailed immune profiling of matched tumor and blood samples.
- Identify nervous system tumor biomarkers and develop non-invasive approaches to diagnose cancer and follow tumor progression by characterizing cerebrospinal fluid and blood samples.
- Characterize and correlate gut and tumor microbiomes to determine if and how the microbiome affects tumor biology, treatment responses and overall patient outcomes.
Genetically Engineerd Natural Killer Cell Therapy
A project that advances the use of genetically engineered natural killer (NK) cell therapy in treating glioblastoma. After learning how NK cells, a type of immune cell, are suppressed by the glioblastoma tumor microenvironment, the Moon Shot team is now creating NK cells that are genetically engineered to resist that immune suppression.
ACCELERATE
A project that will directly tackle the more rigorous vetting of agents that are identified in the discovery stage and considered promising for clinical trials. ACCELERATE will leverage multiple preclinical platforms to create a robust strategy for rigorous testing of novel agents so that definitive and confident Go/No-Go decisions can be made more efficiently.
Viro-Immunotherapy
The Moon Shot has successfully developed Delta-24-RGD, a cold virus engineered to infect and attack glioblastoma cells. Researchers are exploring the possibility of delivering the virus directly to the tumor using stem cells derived from bone marrow called mesenchymal stem cells (MSCs).
Brain Cancer SPORE
Overview
The Brain Cancer SPORE is a translational research program funded by the National Cancer Institute to enable the rapid and efficient movement of basic scientific findings into the clinical setting. Frederick Lang, M.D., PI, and Juan Fueyo, M.D., serve as the co-principal investigators. Research projects include:
- Oncolytic Adenoviruses for Glioma Therapy
- Off-the-shelf Genetically Engineered Natural Killer Therapy for Glioblastoma
- Deciphering Germline and Somatic Genomic Landscape of Gliomas in Black and Hispanic Minority Groups
What is the Brain Cancer SPORE?
The Brain Tumor Center at MD Anderson Cancer Center established a Specialized Program of Research Excellence (SPORE) for the study of brain cancer under the leadership of principal investigator, W. K. Alfred Yung, M.D., and co-principal investigator, Oliver Bögler, Ph.D., in July of 2008. Since that time the SPORE grant has been renewed under the leadership of Frederick Lang, M.D., and Juan Fueyo, M.D., making MD Anderson one of only five programs in the nation with a Brain SPORE grant. This grant supports an outstanding multidisciplinary group of investigators whose research is both innovative and translational.
Oncolytic Adenovirus for Glioma Therapy
- Specific Aim 1: Test the combination of Delta-24-RGD with anti-PD-1 antibodies in patients with recurrent malignant gliomas.
- Specific Aim 2: Assess the safety and biological effects of a next-generation Delta-24-RGD expressing OX40L in patients with recurrent glioma.
- Specific Aim 3: Characterize the antiglioma-potency elicited by Delta-24-RGDOX, Delta-24-GREAT, Delta-24-ACT and their combinations.
Off-the-shelf Genetically Engineered Natural Killer Therapy for Glioblastoma
- Specific Aim 1: To initiate a Phase 1/II study of the safety and efficacy of TGF-βR2-/NR3C1-CB-NK cells in relapsed/recurrent GBM.
- Specific Aim 2: Study the fate of TGF-βR2-/NR3C1-CB-NK cells and associated immune changes in the CNS and correlate the findings with disease response.
- Specific Aim 3: Determine if the membrane-anchored IL-12, IL-21 or IL-15 can further increase the persistence and potency of TGF-βR2-/NR3C1-CB-NK cells against GBM without undue toxicity.
Deciphering Germline and Somatic Genomic Landscape of Gliomas in Black and Hispanic Minority Groups
- Specific Aim 1: Characterize the somatic genomic landscape of gliomas in Black and Hispanic patients.
- Specific Aim 2: Determine the extent to which racial and ethnic composition in Blacks and Hispanics correlates with disease-defining molecular alterations.
- Specific Aim 3: Evaluate the extent to which germline and the somatic variation in Blacks and Hispanics impacts clinical outcome.
Research Laboratories
Lang Laboratory
Welcome to the Lang Laboratory. We are a clinical and translational research laboratory in the Brain Tumor Center within the Neurosurgery department at MD Anderson Cancer Center. Our research focuses on developing “biological therapies,” which we define as naturally occurring viruses, cells or molecules, whose intrinsic properties can be exploited for treating brain tumors. Frederick Lang, M.D., is chair of the Neurosurgery department, the principal investigator for MD Anderson’s Brain Cancer SPORE grant, and a co-leader of the Glioblastoma Moon Shot. The goal of the laboratory is to translate innovative biological therapeutic approaches to the clinic.
McCarty Laboratory
The McCarty Laboratory uses genetically engineered animal models, primary cell culture systems and human tissue samples to study adhesion and signaling pathways that regulate brain development and cancer. In particular, we study how integrins and their extracellular matrix (ECM) protein ligands mediate bi-directional communication between glial cells or glioma cells and blood vessels in the brain microenvironment.
Akdemir Laboratory
The Akdemir lab focuses on integrative computational analyses to advance efforts for precision cancer medicine. We are analyzing multi-omics datasets from primary human tumors, such as long-read whole genome sequencing, genome-wide chromatin organization (Hi-C) and single-cell ATAC-sequencing from common (i.e. glioblastoma) or rare (i.e. chordoma) CNS tumor types to investigate how tumor evolution shapes the organization of chromatin in cancer cells and tumor microenvironment.
Ene Laboratory
PI: Chibawanye I. Ene, M.D., Ph.D.
The Ene laboratory is focused on developing novel immune therapies for the treatment of glioblastoma by reprogramming dysfunctional myeloid cells in the tumor microenvironment to promote eradication of tumor cells.
Kim Laboratory
Dr. Kim’s laboratory takes a multidisciplinary approach to the research of solid tumors with a specific focus on malignant primary and metastatic brain tumors.
Alvarez-Breckenridge Laboratory
PI: Christopher Alvarez-Breckenridge M.D., Ph.D.
The Alvarez-Breckenridge laboratory is a collaborative, translational research group that focuses on metastatic disease of the brain and spine. We study the unique tumor microenvironmental features of brain and spine metastasis and primary spine tumors by analyzing the cellular composition, associated cellular interactions, and the genetic, epigenetic and transcriptional basis of tumor formation and treatment resistance. We also explore the unique features of immune cell priming and trafficking, T-cell clonal expansion, and myeloid cell regulation within both cranial and extracranial sites of disease with a view to apply our findings to develop new immunotherapeutic, clinically translational approaches to treat these tumors.
North Laboratory
The North Laboratory focuses on developing new treatments for peripheral nerve and spinal cord dysfunction associated with cancer. Specifically, we are interested in neuropathic pain, nerve reconstruction for nerve and spinal cord injury, radiation-related injury and chemotherapy-induced peripheral neuropathy.
Tatsui Laboratory
The Tatsui Laboratory explores new therapies for metastatic tumors of the spine, minimally invasive MRI guided ablation of epidural metastasis and methods of spine stabilization. Currently, there are few options to treat spine metastases that are refractory to radiation, and our translational research aims to develop a clinical application for the use of tumor treating fields in combination with surgery for management of radiation refractory spinal tumors. We are also evaluating the radiological properties and benefits of carbon fiber pedicle screws for spine stabilization in the setting of primary or metastatic tumors of the spine.
Publications by Year
Publications- 2022
1. Ziyaee H, Cardenas CE, Yeboa DN, Li J, Ferguson SD, Johnson J, Zhou Z, Sanders J, Mumme R, Court L, Briere T, Yang J. Automated Brain Metastases Segmentation With a Deep Dive Into False-positive Detection. Adv Radiat Oncol. 2023 Jan-Feb;8(1):101085. doi: 10.1016/j.adro.2022.101085. eCollection 2023 Jan-Feb. PubMed PMID: 36299565; PubMed Central PMCID: PMC9589017.
2. Xu Z, Lee DS, Chandran S, Le VT, Bump R, Yasis J, Dallarda S, Marcotte S, Clock B, Haghani N, Cho CY, Akdemir KC, Tyndale S, Futreal PA, McVicker G, Wahl GM, Dixon JR. Structural variants drive context-dependent oncogene activation in cancer. Nature. 2022 Dec 7;. doi: 10.1038/s41586-022-05504-4. [Epub ahead of print] PubMed PMID: 36477537.
3. Huntoon K, Anderson SK, Ballman KV, Twohy E, Dooley K, Jiang W, An Y, Li J, von Roemeling C, Qie Y, Ross OA, Cerhan JH, Whitton AC, Greenspoon JN, Parney IF, Ashman JB, Bahary JP, Hadjipanayis C, Urbanic JJ, Farace E, Khuntia D, Laack NN, Brown PD, Roberge D, Kim BYS. Association of Circulating Markers with Cognitive Decline After Radiation Therapy for Brain Metastasis. Neuro Oncol. 2022 Dec 6;. doi: 10.1093/neuonc/noac262. [Epub ahead of print] PubMed PMID: 36472389.
4. Hernández-Verdin I, Akdemir KC, Ramazzotti D, Caravagna G, Labreche K, Mokhtari K, Hoang-Xuan K, Peyre M, Bielle F, Touat M, Idbaih A, Duval A, Sanson M, Alentorn A. Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response. NPJ Precis Oncol. 2022 Dec 1;6(1):89. doi: 10.1038/s41698-022-00331-2. PubMed PMID: 36456685; PubMed Central PMCID: PMC9715662.
5. Yeh MY, Chen HS, Hou P, Kumar VA, Johnson JM, Noll KR, Prabhu SS, Ferguson SD, Schomer DF, Peng HH, Liu HL. Cerebrovascular Reactivity Mapping Using Resting-State Functional MRI in Patients With Gliomas. J Magn Reson Imaging. 2022 Dec;56(6):1863-1871. doi: 10.1002/jmri.28194. Epub 2022 Apr 9. PubMed PMID: 35396789.
6. Muir M, Gadot R, Prinsloo S, Michener H, Traylor J, Athukuri P, Tummala S, Kumar VA, Prabhu SS. Comparative study of preoperative functional imaging combined with tractography for prediction of iatrogenic motor deficits. J Neurosurg. 2022 Nov 25;:1-8. doi: 10.3171/2022.10.JNS221684. [Epub ahead of print] PubMed PMID: 36433877.
7. Lu Y, Huntoon K, Lee D, Wang Y, Ha J, Qie Y, Li X, Schrank BR, Dong S, Gallup TD, Kang M, Zhao H, An Y, Yang Z, Li J, Kim BYS, Jiang W. Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy. Nat Nanotechnol. 2022 Nov 10;. doi: 10.1038/s41565-022-01245-7. [Epub ahead of print] PubMed PMID: 36357792.
8. Lopez G, Eng C, Overman M, Ramirez D, Liu W, Beinhorn C, Sumler P, Prinsloo S, Li Y, Chen M, Bruera E, Cohen L. A randomized pilot study of oncology massage to treat chemotherapy-induced peripheral neuropathy. Sci Rep. 2022 Nov 8;12(1):19023. doi: 10.1038/s41598-022-23372-w. PubMed PMID: 36348045; PubMed Central PMCID: PMC9643426.
9. Kesler SR, Harrison RA, Rao V, Dyson H, Petersen M, Prinsloo S. Predicting overall survival in diffuse glioma from the presurgical connectome. Sci Rep. 2022 Nov 5;12(1):18783. doi: 10.1038/s41598-022-22387-7. PubMed PMID: 36335224; PubMed Central PMCID: PMC9637134.
10. Allam AK, Larkin MB, Katlowitz KA, Shofty B, Viswanathan A. Case report: MR-guided laser induced thermal therapy for palliative cingulotomy. Front Pain Res (Lausanne). 2022;3:1028424. doi: 10.3389/fpain.2022.1028424. eCollection 2022. PubMed PMID: 36387414; PubMed Central PMCID: PMC9663803.
11. Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, Bosenberg M, Brastianos P, Cahill DP, Chen Q, Ferguson S, Forsyth P, Glitza Oliva IC, Goldberg SB, Holmen SL, Knisely JPS, Merlino G, Nguyen DX, Pacold ME, Perez-Guijarro E, Smalley KSM, Tawbi HA, Wen PY, Davies MA, Kluger HM, Mehnert JM, Hernando E. Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Pigment Cell Melanoma Res. 2022 Nov;35(6):554-572. doi: 10.1111/pcmr.13059. Epub 2022 Sep 1. Review. PubMed PMID: 35912544.
12. Asman P, Pellizzer G, Tummala S, Tasnim I, Bastos D, Bhavsar S, Prabhu S, Ince NF. Long-latency gamma modulation after median nerve stimulation delineates the central sulcus and contrasts the states of consciousness. Clin Neurophysiol. 2022 Oct 31;145:1-10. doi: 10.1016/j.clinph.2022.10.008. [Epub ahead of print] PubMed PMID: 36370685.
13. Amit M, Xie T, Gleber-Netto FO, Hunt PJ, Mehta GU, Bell D, Silverman DA, Yaman I, Ye Y, Burks JK, Fuller GN, Gidley PW, Nader ME, Raza SM, DeMonte F. Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology. J Exp Clin Cancer Res. 2022 Oct 4;41(1):292. doi: 10.1186/s13046-022-02473-4. PubMed PMID: 36195959; PubMed Central PMCID: PMC9531347.
14. Bishop AJ, Amini B, Lin H, Raza SM, Patel S, Grosshans DR, Ghia A, Farooqi A, Guadagnolo BA, Mitra D, Akdemir KC, Lazar AJ, Wang WL, Alvarez-Breckenridge C, Bird J, Rhines LD, Somaiah N, Conley AP. Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma. J Immunother. 2022 Oct 1;45(8):374-378. doi: 10.1097/CJI.0000000000000431. Epub 2022 Aug 4. PubMed PMID: 35943386; PubMed Central PMCID: PMC9452485.
15. Rubino F, Alvarez-Breckenridge C, Akdemir K, Conley AP, Bishop AJ, Wang WL, Lazar AJ, Rhines LD, DeMonte F, Raza SM. Prognostic molecular biomarkers in chordomas: A systematic review and identification of clinically usable biomarker panels. Front Oncol. 2022;12:997506. doi: 10.3389/fonc.2022.997506. eCollection 2022. PubMed PMID: 36248987; PubMed Central PMCID: PMC9557284.
16. Muir M, Prinsloo S, Michener H, Shetty A, de Almeida Bastos DC, Traylor J, Ene C, Tummala S, Kumar VA, Prabhu SS. Transcranial magnetic stimulation (TMS) seeded tractography provides superior prediction of eloquence compared to anatomic seeded tractography. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac126. doi: 10.1093/noajnl/vdac126. eCollection 2022 Jan-Dec. PubMed PMID: 36128584; PubMed Central PMCID: PMC9476227.
17. Gates EDH, Suki D, Celaya A, Weinberg JS, Prabhu SS, Sawaya R, Huse JT, Long JP, Fuentes D, Schellingerhout D. Cellular Density in Adult Glioma, Estimated with MR Imaging Data and a Machine Learning Algorithm, Has Prognostic Power Approaching World Health Organization Histologic Grading in a Cohort of 1181 Patients. AJNR Am J Neuroradiol. 2022 Sep 15;. doi: 10.3174/ajnr.A7620. [Epub ahead of print] PubMed PMID: 36109124; PubMed Central PMCID: PMC9575543.
18. Habib A, Edem I, Bell D, Su SY, Hanna EY, Kupferman ME, DeMonte F, Raza SM. Soft Tissue Sarcomas of the Head and Neck Region with Skull Base/Intracranial Invasion: Review of Surgical Outcomes and Multimodal Treatment Strategies: A Retrospective Case Series. Curr Oncol. 2022 Sep 14;29(9):6540-6550. doi: 10.3390/curroncol29090514. PubMed PMID: 36135083; PubMed Central PMCID: PMC9498209.
19. Allam AK, Larkin MB, McGinnis JP, Viswanathan A. Neuroablative central lateral thalamotomy for chronic neuropathic pain. Front Pain Res (Lausanne). 2022;3:999891. doi: 10.3389/fpain.2022.999891. eCollection 2022. Review. PubMed PMID: 36176711; PubMed Central PMCID: PMC9513204.
20. Lazaro TT, Katlowitz KA, Karas PJ, Srinivasan VM, Walls E, Collier G, Raza SM, Curry DJ, Ropper AE, Fuentes A, Gopinath SP, Rao G, Patel AJ. The impact of a night float system on operative experience in neurosurgery residency. J Neurosurg. 2022 Sep 9;:1-7. doi: 10.3171/2022.4.JNS212612. [Epub ahead of print] PubMed PMID: 36087325.
21. Pokhylevych H, Khose S, Gule-Monroe MK, Chen MM, Fuller G, Gruschkus SK, Sadighi Z, Zaky W, Sandberg DI, McGovern SL, Johnson JM. Contrast Enhancement Patterns in Pediatric Glioblastomas. J Comput Assist Tomogr. 2022 Sep 7;. doi: 10.1097/RCT.0000000000001379. [Epub ahead of print] PubMed PMID: 36112052.
22. Schur S, Passer JZ, Hanna EY, Su SY, Kupferman ME, DeMonte F, Raza SM. The impact of expanded endoscopic approaches on oncologic and functional outcomes for clival malignancies:a case series. J Neurooncol. 2022 Sep;159(3):627-635. doi: 10.1007/s11060-022-04103-7. Epub 2022 Aug 16. PubMed PMID: 35972674.
23. Bahouth SM, Yeboa DN, Ghia AJ, Tatsui CE, Alvarez-Breckenridge CA, Beckham TH, Bishio AJ, Li J, McAleer MF, North RY, Rhines LD, Swanson TA, Chenyang W, Amini B. Multidisciplinary management of spinal metastases: what the radiologist needs to know. Br J Radiol. 2022 Sep 1;95(1138):20220266. doi: 10.1259/bjr.20220266. Epub 2022 Aug 10. Review. PubMed PMID: 35856792.
24. Hasanov E, Yeboa DN, Tucker MD, Swanson TA, Beckham TH, Rini B, Ene CI, Hasanov M, Derks S, Smits M, Dudani S, Heng DYC, Brastianos PK, Bex A, Hanalioglu S, Weinberg JS, Hirsch L, Carlo MI, Aizer A, Brown PD, Bilen MA, Chang EL, Jaboin J, Brugarolas J, Choueiri TK, Atkins MB, McGregor BA, Halasz LM, Patel TR, Soltys SG, McDermott DF, Elder JB, Baskaya MK, Yu JB, Timmerman R, Kim MM, Mut M, Markert J, Beal K, Tannir NM, Samandouras G, Lang FF, Giles R, Jonasch E. An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma. CA Cancer J Clin. 2022 Sep;72(5):454-489. doi: 10.3322/caac.21729. Epub 2022 Jun 16. Review. PubMed PMID: 35708940.
25. Mercau ME, Patwa S, Bhat KPL, Ghosh S, Rothlin CV. Cell death in development, maintenance, and diseases of the nervous system. Semin Immunopathol. 2022 Sep;44(5):725-738. doi: 10.1007/s00281-022-00938-4. Epub 2022 May 4. Review. PubMed PMID: 35508671.
26. Bahouth SM, Yeboa DN, Ghia AJ, Tatsui CE, Alvarez-Breckenridge CA, Beckham TH, Bishop AJ, Li J, McAleer MF, North RY, Rhines LD, Swanson TA, Chenyang W, Amini B. Advances in the management of spinal metastases: what the radiologist needs to know. Br J Radiol. 2022 Aug 24;:20220267. doi: 10.1259/bjr.20220267. [Epub ahead of print] Review. PubMed PMID: 35946551.
27. Upadhyay R, Khose S, Pokhylevych H, Paulino AC, McAleer MF, Ghia A, Li J, Yeboa DN, Loghin M, Harrison R, O'Brien B, Kamiya-Matsuoka C, De Groot J, Puduvalli VK, Tatsui C, Alvarez-Breckenridge C, Prabhu S, Rhines L, Zaky W, Lin F, Weinberg JS, Fuller G, Sandberg DI, Johnson JM, McGovern SL. Patterns of failure after radiation therapy in primary spinal high-grade gliomas: A single institutional analysis. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac129. doi: 10.1093/noajnl/vdac129. eCollection 2022 Jan-Dec. PubMed PMID: 36128585; PubMed Central PMCID: PMC9476222.
28. Mateescu B, Jones JC, Alexander RP, Alsop E, An JY, Asghari M, Boomgarden A, Bouchareychas L, Cayota A, Chang HC, Charest A, Chiu DT, Coffey RJ, Das S, De Hoff P, deMello A, D'Souza-Schorey C, Elashoff D, Eliato KR, Franklin JL, Galas DJ, Gerstein MB, Ghiran IH, Go DB, Gould S, Grogan TR, Higginbotham JN, Hladik F, Huang TJ, Huo X, Hutchins E, Jeppesen DK, Jovanovic-Talisman T, Kim BYS, Kim S, Kim KM, Kim Y, Kitchen RR, Knouse V, LaPlante EL, Lebrilla CB, Lee LJ, Lennon KM, Li G, Li F, Li T, Liu T, Liu Z, Maddox AL, McCarthy K, Meechoovet B, Maniya N, Meng Y, Milosavljevic A, Min BH, Morey A, Ng M, Nolan J, De Oliveira Junior GP, Paulaitis ME, Phu TA, Raffai RL, Reátegui E, Roth ME, Routenberg DA, Rozowsky J, Rufo J, Senapati S, Shachar S, Sharma H, Sood AK, Stavrakis S, Stürchler A, Tewari M, Tosar JP, Tucker-Schwartz AK, Turchinovich A, Valkov N, Van Keuren-Jensen K, Vickers KC, Vojtech L, Vreeland WN, Wang C, Wang K, Wang Z, Welsh JA, Witwer KW, Wong DTW, Xia J, Xie YH, Yang K, Zaborowski MP, Zhang C, Zhang Q, Zivkovic AM, Laurent LC. Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research. iScience. 2022 Aug 19;25(8):104653. doi: 10.1016/j.isci.2022.104653. eCollection 2022 Aug 19. Review. PubMed PMID: 35958027; PubMed Central PMCID: PMC9358052.
29. Modrek AS, Eskilsson E, Ezhilarasan R, Wang Q, Goodman LD, Ding Y, Zhang ZY, Bhat KPL, Le TT, Barthel FP, Tang M, Yang J, Long L, Gumin J, Lang FF, Verhaak RGW, Aldape KD, Sulman EP. PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells. Front Oncol. 2022;12:941657. doi: 10.3389/fonc.2022.941657. eCollection 2022. PubMed PMID: 36059614; PubMed Central PMCID: PMC9434399.
30. Alvarez-Breckenridge C, Markson SC, Stocking JH, Nayyar N, Lastrapes M, Strickland MR, Kim AE, de Sauvage M, Dahal A, Larson JM, Mora JL, Navia AW, Klein RH, Kuter BM, Gill CM, Bertalan M, Shaw B, Kaplan A, Subramanian M, Jain A, Kumar S, Danish H, White M, Shahid O, Pauken KE, Miller BC, Frederick DT, Hebert C, Shaw M, Martinez-Lage M, Frosch M, Wang N, Gerstner E, Nahed BV, Curry WT, Carter B, Cahill DP, Boland GM, Izar B, Davies MA, Sharpe AH, Suvà ML, Sullivan RJ, Brastianos PK, Carter SL. Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition. Cancer Immunol Res. 2022 Aug 3;10(8):996-1012. doi: 10.1158/2326-6066.CIR-21-0870. PubMed PMID: 35706413.
31. Liu CC, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, Doss SV, Shue F, Jeevaratnam S, Bastea L, Wang N, Martens YA, Qiao W, Wang M, Zhao N, Jia L, Yamazaki Y, Yamazaki A, Rosenberg CL, Wang Z, Kong D, Li Z, Kuchenbecker LA, Trottier ZA, Felton L, Rogers J, Quicksall ZS, Linares C, Knight J, Chen Y, Kurti A, Kanekiyo T, Fryer JD, Asmann YW, Storz P, Wang X, Peng J, Zhang B, Kim BYS, Bu G. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nat Neurosci. 2022 Aug;25(8):1020-1033. doi: 10.1038/s41593-022-01127-0. Epub 2022 Aug 1. PubMed PMID: 35915180.
32. Li X, Khorsandi S, Wang Y, Santelli J, Huntoon K, Nguyen N, Yang M, Lee D, Lu Y, Gao R, Kim BYS, de Gracia Lux C, Mattrey RF, Jiang W, Lux J. Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles. Nat Nanotechnol. 2022 Aug;17(8):891-899. doi: 10.1038/s41565-022-01134-z. Epub 2022 May 30. PubMed PMID: 35637356; PubMed Central PMCID: PMC9378430.
33. North RY, Odem MA, Li Y, Tatsui CE, Cassidy RM, Dougherty PM, Walters ET. Electrophysiological Alterations Driving Pain-Associated Spontaneous Activity in Human Sensory Neuron Somata Parallel Alterations Described in Spontaneously Active Rodent Nociceptors. J Pain. 2022 Aug;23(8):1343-1357. doi: 10.1016/j.jpain.2022.02.009. Epub 2022 Mar 12. PubMed PMID: 35292377; PubMed Central PMCID: PMC9357108.
34. Muir M, Traylor JI, Gadot R, Patel R, Prabhu SS. Repeat laser interstitial thermal therapy for recurrent primary and metastatic intracranial tumors. Surg Neurol Int. 2022;13:311. doi: 10.25259/SNI_418_2022. eCollection 2022. PubMed PMID: 35928321; PubMed Central PMCID: PMC9345120.
35. Ray PR, Shiers S, Caruso JP, Tavares-Ferreira D, Sankaranarayanan I, Uhelski ML, Li Y, North RY, Tatsui C, Dussor G, Burton MD, Dougherty PM, Price TJ. RNA profiling of human dorsal root ganglia reveals sex-differences in mechanisms promoting neuropathic pain. Brain. 2022 Jul 22;. doi: 10.1093/brain/awac266. [Epub ahead of print] PubMed PMID: 35867896.
36. Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022 Jul;10(7). doi: 10.1136/jitc-2022-004935. PubMed PMID: 35902132; PubMed Central PMCID: PMC9341188.
37. MacLean MA, Touchette CJ, Georgiopoulos M, Brunette-Clément T, Abduljabbar FH, Ames CP, Bettegowda C, Charest-Morin R, Dea N, Fehlings MG, Gokaslan ZL, Goodwin CR, Laufer I, Netzer C, Rhines LD, Sahgal A, Shin JH, Sciubba DM, Stephens BF, Fourney DR, Weber MH. Systemic considerations for the surgical treatment of spinal metastatic disease: a scoping literature review. Lancet Oncol. 2022 Jul;23(7):e321-e333. doi: 10.1016/S1470-2045(22)00126-7. PubMed PMID: 35772464.
38. Johnson JN, Srivatsan A, Chueh J, Arslanian R, Gounis MJ, Puri AS, Srinivasan VM, Chen SR, Burkhardt JK, Kan P. Impact of histological clot composition on preprocedure imaging and mechanical thrombectomy. Brain Circ. 2022 Apr-Jun;8(2):87-93. doi: 10.4103/bc.bc_81_21. eCollection 2022 Apr-Jun. PubMed PMID: 35909711; PubMed Central PMCID: PMC9336592.
39. Gállego Pérez-Larraya J, Garcia-Moure M, Labiano S, Patiño-García A, Dobbs J, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, Puigdelloses M, Laspidea V, Astigarraga I, Lopez-Ibor B, Cruz O, Oscoz Lizarbe M, Hervas-Stubbs S, Alkorta-Aranburu G, Tamayo I, Tavira B, Hernandez-Alcoceba R, Jones C, Dharmadhikari G, Ruiz-Moreno C, Stunnenberg H, Hulleman E, van der Lugt J, Idoate MÁ, Diez-Valle R, Esparragosa Vázquez I, Villalba M, de Andrea C, Núñez-Córdoba JM, Ewald B, Robbins J, Fueyo J, Gomez-Manzano C, Lang FF, Tejada S, Alonso MM. Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med. 2022 Jun 30;386(26):2471-2481. doi: 10.1056/NEJMoa2202028. PubMed PMID: 35767439.
40. Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022 Jun 22;7(12). doi: 10.1172/jci.insight.148990. PubMed PMID: 35653194; PubMed Central PMCID: PMC9309065.
41. Mattogno PP, Marciano F, Catalino MP, Mattavelli D, Cocca P, Lopomo NF, Nicolai P, Laws ER Jr, Witterick I, Raza SM, Devaiah AK, Lauretti L, Olivi A, Fontanella MM, Gentili F, Doglietto F. Ergonomics in Endoscopic Transsphenoidal Surgery: A Survey of the North American Skull Base Society. J Neurol Surg B Skull Base. 2022 Jun;83(Suppl 2):e380-e385. doi: 10.1055/s-0041-1729906. eCollection 2022 Jun. PubMed PMID: 35832944; PubMed Central PMCID: PMC9272277.
42. Bishop AJ, Zheng J, Subramaniam A, Ghia AJ, Wang C, McGovern SL, Patel S, Guadagnolo BA, Mitra D, Farooqi A, Reardon MJ, Kim B, Guha-Thakurta N, Li J, Ravi V. Cardiac Angiosarcomas: Risk of Brain Metastasis and Hemorrhage Warrants Frequent Surveillance Imaging and Early Intervention. Am J Clin Oncol. 2022 Jun 1;45(6):258-263. doi: 10.1097/COC.0000000000000913. Epub 2022 Apr 26. PubMed PMID: 35588225; PubMed Central PMCID: PMC9179017.
43. Muir M, Rhines L, Demonte F, Tatsui C, Raza SM. Impact of Radiation Therapy on Outcomes After Spinal Instrumentation for Craniocervical Junction Malignancies. Neurospine. 2022 Jun;19(2):434-440. doi: 10.14245/ns.2244034.017. Epub 2022 May 15. PubMed PMID: 35577332; PubMed Central PMCID: PMC9260556.
44. Bhalla AD, Landers SM, Singh AK, Landry JP, Yeagley MG, Myerson GSB, Delgado-Baez CB, Dunnand S, Nguyen T, Ma X, Bolshakov S, Menegaz BA, Lamhamedi-Cherradi SE, Mao X, Song X, Lazar AJ, McCutcheon IE, Slopis JM, Ludwig JA, Lev DC, Rai K, Torres KE. Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor. Lab Invest. 2022 Jun;102(6):658-666. doi: 10.1038/s41374-022-00734-6. Epub 2022 Feb 28. PubMed PMID: 35228656.
45. Chen SR, Chen MM, Ene C, Lang FF, Kan P. Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors. J Neurointerv Surg. 2022 Jun;14(6):533-538. doi: 10.1136/neurintsurg-2021-018190. Epub 2021 Nov 25. PubMed PMID: 34824133.
46. Muir M, Prinsloo S, Traylor JI, Patel R, Ene C, Tummala S, Prabhu SS. Transcranial magnetic stimulation tractography and the facilitation of gross total resection in a patient with a motor eloquent glioblastoma: illustrative case. J Neurosurg Case Lessons. 2022 May 16;3(20). doi: 10.3171/CASE22128. Print 2022 May 16. PubMed PMID: 36303481; PubMed Central PMCID: PMC9379643.
47. Uhelski ML, Gorur A, Shi T, Corrales G, Du KN, Li Y, Amit M, Tatsui CE, Rhines LD, Dougherty PM, Cata JP. Fadu head and neck squamous cell carcinoma induces hyperexcitability of primary sensory neurons in an in vitro coculture model. Pain Rep. 2022 May-Jun;7(3):e1012. doi: 10.1097/PR9.0000000000001012. eCollection 2022 May-Jun. PubMed PMID: 35620249; PubMed Central PMCID: PMC9113206.
48. McCutcheon IE. Seizures and pseudoseizures: The great divide. Prog Brain Res. 2022;272(1):143-151. doi: 10.1016/bs.pbr.2022.03.003. Epub 2022 May 14. Review. PubMed PMID: 35667799.
49. Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A, Krishnan SN, Varn FS, Arrieta VA, Gupta P, Ferguson SD, Huse JT, Fuller GN, Long JP, Winkowski DE, Freiberg BA, James CD, Platanias LC, Lesniak MS, Burks JK, Heimberger AB. Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression. JCI Insight. 2022 May 9;7(9). doi: 10.1172/jci.insight.157612. PubMed PMID: 35316217; PubMed Central PMCID: PMC9090258.
50. Alvarez-Breckenridge CA, Cahill DP, Brastianos PK. Trabectedin for recurrent WHO grade 2 or 3 meningiomas-Paving the road for new opportunities. Neuro Oncol. 2022 May 4;24(5):768-769. doi: 10.1093/neuonc/noac017. PubMed PMID: 35100424; PubMed Central PMCID: PMC9071327.
51. Strickland MR, Alvarez-Breckenridge C, Gainor JF, Brastianos PK. Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity. Cancer Discov. 2022 May 2;12(5):1199-1216. doi: 10.1158/2159-8290.CD-21-0976. Review. PubMed PMID: 35394521.
52. Xu J, Wu PJ, Lai TH, Sharma P, Canella A, Welker AM, Beattie CE, Elder JB, Easley M, Lonser R, Jacob NK, Pietrzak M, Timmers CM, Lang F, Sampath D, Puduvalli VK. Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy. Clin Cancer Res. 2022 May 2;28(9):1979-1990. doi: 10.1158/1078-0432.CCR-20-0468. PubMed PMID: 35140124; PubMed Central PMCID: PMC9064967.
53. Rogers JL, De La Cruz Minyety J, Vera E, Acquaye AA, Payén SS, Weinberg JS, Armstrong TS, Weathers SS. Assessing mobility in primary brain tumor patients: A descriptive feasibility study using two established mobility tests. Neurooncol Pract. 2022 May;9(3):219-228. doi: 10.1093/nop/npac013. eCollection 2022 May. PubMed PMID: 35601968; PubMed Central PMCID: PMC9113321.
54. Chen SR, Lang FF, Kan P. Preclinical animal brain tumor models for interventional neuro-oncology. J Neurointerv Surg. 2022 May;14(5). doi: 10.1136/neurintsurg-2022-018968. PubMed PMID: 35414632.
55. Sun X, Zhai J, Sun B, Parra ER, Jiang M, Ma W, Wang J, Kang AM, Kannan K, Pandurengan R, Zhang S, Solis LM, Haymaker CL, Raso MG, Mendoza Perez J, Sahin AA, Wistuba II, Yam C, Litton JK, Yang F. Effector memory cytotoxic CD3+/CD8+/CD45RO+ T cells are predictive of good survival and a lower risk of recurrence in triple-negative breast cancer. Mod Pathol. 2022 May;35(5):601-608. doi: 10.1038/s41379-021-00973-w. Epub 2021 Nov 27. PubMed PMID: 34839351.
56. Gopakumar S, McDonald MF, Sharma H, Tatsui CE, Fuller GN, Rao G. Recurrent HGNET-MN1 altered (astroblastoma MN1-altered) of the foramen magnum: Case report and molecular classification. Surg Neurol Int. 2022;13:139. doi: 10.25259/SNI_1208_2021. eCollection 2022. PubMed PMID: 35509530; PubMed Central PMCID: PMC9062895.
57. van Putten EHP, Kleijn A, van Beusechem VW, Noske D, Lamers CHJ, de Goede AL, Idema S, Hoefnagel D, Kloezeman JJ, Fueyo J, Lang FF, Teunissen CE, Vernhout RM, Bakker C, Gerritsen W, Curiel DT, Vulto A, Lamfers MLM, Dirven CMF. Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies. Clin Cancer Res. 2022 Apr 14;28(8):1572-1585. doi: 10.1158/1078-0432.CCR-21-3324. PubMed PMID: 35176144.
58. de Groot JF, Kim AH, Prabhu S, Rao G, Laxton AW, Fecci PE, O'Brien BJ, Sloan A, Chiang V, Tatter SB, Mohammadi AM, Placantonakis DG, Strowd RE, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope KD, Campian JL, Kurz SC, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt EC. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac040. doi: 10.1093/noajnl/vdac040. eCollection 2022 Jan-Dec. PubMed PMID: 35611270; PubMed Central PMCID: PMC9122789.
59. Li T, Mehraein-Ghomi F, Forbes ME, Namjoshi SV, Ballard EA, Song Q, Chou PC, Wang X, Parker Kerrigan BC, Lang FF, Lesser G, Debinski W, Yang X, Zhang W. HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion. Mol Ther. 2022 Apr 6;30(4):1610-1627. doi: 10.1016/j.ymthe.2022.02.009. Epub 2022 Feb 10. PubMed PMID: 35151844; PubMed Central PMCID: PMC9077375.
60. Vogelbaum MA, Li G, Heimberger AB, Lang FF, Fueyo J, Gomez-Manzano C, Sanai N. A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-8. doi: 10.1200/EDBK_349175. PubMed PMID: 35580289.
61. Alvarez-Breckenridge C, Remon J, Piña Y, Nieblas-Bedolla E, Forsyth P, Hendriks L, Brastianos PK. Emerging Systemic Treatment Perspectives on Brain Metastases: Moving Toward a Better Outlook for Patients. Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-19. doi: 10.1200/EDBK_352320. PubMed PMID: 35522917.
62. Dong S, Bi Y, Sun X, Zhao Y, Sun R, Hao F, Sun Y, Wang Y, Li X, Deng W, Liu X, Ha J, Teng L, Gong P, Xie J, Kim BYS, Yang Z, Jiang W, Teng L. Dual-Loaded Liposomes Tagged with Hyaluronic Acid Have Synergistic Effects in Triple-Negative Breast Cancer. Small. 2022 Apr;18(16):e2107690. doi: 10.1002/smll.202107690. Epub 2022 Mar 11. PubMed PMID: 35277914.
63. Gates EDH, Celaya A, Suki D, Schellingerhout D, Fuentes D. An efficient magnetic resonance image data quality screening dashboard. J Appl Clin Med Phys. 2022 Apr;23(4):e13557. doi: 10.1002/acm2.13557. Epub 2022 Feb 11. PubMed PMID: 35148034; PubMed Central PMCID: PMC8992954.
64. Bell D, Phan J, DeMonte F, Hanna EY. High-grade transformation of low-grade biphenotypic sinonasal sarcoma: Radiological, morphophenotypic variation and confirmatory molecular analysis. Ann Diagn Pathol. 2022 Apr;57:151889. doi: 10.1016/j.anndiagpath.2021.151889. Epub 2022 Jan 10. PubMed PMID: 35030392.
65. Muir M, Patel R, Traylor JI, de Almeida Bastos DC, Kamiya C, Li J, Rao G, Prabhu SS. Laser interstitial thermal therapy for newly diagnosed glioblastoma. Lasers Med Sci. 2022 Apr;37(3):1811-1820. doi: 10.1007/s10103-021-03435-6. Epub 2021 Oct 23. PubMed PMID: 34687390.
66. Jiang B, Murray C, Cole BL, Glover JNM, Chan GK, Deschenes J, Mani RS, Subedi S, Nerva JD, Wang AC, Lockwood CM, Mefford HC, Leary SES, Ojemann JG, Weinfeld M, Ene CI. Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor. Sci Rep. 2022 Mar 30;12(1):5386. doi: 10.1038/s41598-022-09097-w. PubMed PMID: 35354845; PubMed Central PMCID: PMC8967877.
67. De A, Morales JE, Chen Z, Sebastian S, McCarty JH. The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development. 2022 Mar 15;149(6). doi: 10.1242/dev.200472. Epub 2022 Mar 18. PubMed PMID: 35217866; PubMed Central PMCID: PMC8977100.
68. Ene CI, Ferguson SD. Surgical Management of Brain Metastasis: Challenges and Nuances. Front Oncol. 2022;12:847110. doi: 10.3389/fonc.2022.847110. eCollection 2022. Review. PubMed PMID: 35359380; PubMed Central PMCID: PMC8963990.
69. Muir M, Patel R, Traylor J, de Almeida Bastos DC, Prinsloo S, Liu HL, Noll K, Wefel J, Tummala S, Kumar V, Prabhu S. Validation of Non-invasive Language Mapping Modalities for Eloquent Tumor Resection: A Pilot Study. Front Neurosci. 2022;16:833073. doi: 10.3389/fnins.2022.833073. eCollection 2022. PubMed PMID: 35299624; PubMed Central PMCID: PMC8923233.
70. Versteeg AL, Elkaim LM, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Fehlings MG, Lazary A, Clarke MJ, Arnold PM, Bettegowda C, Boriani S, Gokaslan ZL, Fisher CG, Weber MH. Steroids in the Management of Preoperative Neurological Deficits in Metastatic Spine Disease: Results From the EPOSO Study. Neurospine. 2022 Mar;19(1):43-50. doi: 10.14245/ns.2142768.384. Epub 2022 Jan 30. PubMed PMID: 35130426; PubMed Central PMCID: PMC8987562.
71. Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF. Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. J Neurosurg. 2022 Mar 1;136(3):757-767. doi: 10.3171/2021.3.JNS203045. Print 2022 Mar 1. PubMed PMID: 34450587.
72. Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci. 2022 Feb 23;42(8):1406-1416. doi: 10.1523/JNEUROSCI.1918-21.2021. Epub 2021 Dec 29. PubMed PMID: 34965971; PubMed Central PMCID: PMC8883848.
73. Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D. Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline. J Clin Oncol. 2022 Feb 10;40(5):492-516. doi: 10.1200/JCO.21.02314. Epub 2021 Dec 21. PubMed PMID: 34932393.
74. Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, Baskin DS, Pichumani K, Ijare OB, Wood SL, Powell SZ, Haviland DL, Parker Kerrigan BC, Lang FF, Prabhu SS, Huntoon KM, Jiang W, Kim BYS, George J, Yun K. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022 Feb 9;13(1):767. doi: 10.1038/s41467-022-28372-y. PubMed PMID: 35140215; PubMed Central PMCID: PMC8828877.
75. Schur SE, Hanna EY, Su SY, Kupferman ME, DeMonte F, Raza SM. Impact of salvage surgery for recurrent sinonasal cancers with skull base and intracranial involvement. J Neurosurg. 2022 Feb 4;:1-8. doi: 10.3171/2021.12.JNS212278. [Epub ahead of print] PubMed PMID: 35120325.
76. Shepard MJ, Haider AS, Prabhu SS, Sawaya R, DeMonte F, McCutcheon IE, Weinberg JS, Ferguson SD, Suki D, Fuller GN, Lang FF. Long term outcomes following surgery for pineal region tumors. J Neurooncol. 2022 Feb;156(3):491-498. doi: 10.1007/s11060-021-03919-z. Epub 2022 Jan 27. PubMed PMID: 35083579.
77. Gibson M, Michalowicz M, Chrisinger JSA, Bell D, Shah K, Demonte F, Gidley PW. Osteoblastoma of the Temporal Bone in a Child. Otol Neurotol. 2022 Feb 1;43(2):e276-e278. doi: 10.1097/MAO.0000000000003381. PubMed PMID: 35015753.
78. Abdelmeguid AS, Bell D, Roberts D, Ferrarotto R, Phan J, Su SY, Kupferman M, Raza S, DeMonte F, Hanna E. Long-Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature. Laryngoscope. 2022 Feb;132(2):290-297. doi: 10.1002/lary.29732. Epub 2021 Jul 17. Review. PubMed PMID: 34272876.
79. Sharma P, Xu J, Williams K, Easley M, Elder JB, Lonser R, Lang FF, Lapalombella R, Sampath D, Puduvalli VK. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress. Neuro Oncol. 2022 Feb 1;24(2):229-244. doi: 10.1093/neuonc/noab175. PubMed PMID: 34260721; PubMed Central PMCID: PMC8804900.
80. Piña Y, Yadugiri S, Yeboa DN, Ferguson SD, Forsyth PA, Oliva ICG. Advances in Diagnosis and Treatment for Leptomeningeal Disease in Melanoma. Curr Oncol Rep. 2022 Jan;24(1):43-54. doi: 10.1007/s11912-021-01162-3. Epub 2022 Jan 20. Review. PubMed PMID: 35059999.
81. Ferguson SD, Fomchenko EI, Guerrieri RA, Glitza Oliva IC. Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD). Front Oncol. 2021;11:800053. doi: 10.3389/fonc.2021.800053. eCollection 2021. Review. PubMed PMID: 35096602; PubMed Central PMCID: PMC8789647.
82. Haghshenas V, Moghimi M, Haghshenas MP, Shin C, Holderread BM, Hirase T, Hanson DS, Rhines L, Marco R. Scoliosis Following Chest Wall Resection for Tumor With and Without Prophylactic Fixation: Case Series. Cureus. 2022 Jan;14(1):e21115. doi: 10.7759/cureus.21115. eCollection 2022 Jan. PubMed PMID: 35165572; PubMed Central PMCID: PMC8830437.
83. Muir M, Prinsloo S, Michener H, Traylor JI, Patel R, Gadot R, de Almeida Bastos DC, Kumar VA, Ferguson S, Prabhu SS. TMS Seeded Diffusion Tensor Imaging Tractography Predicts Permanent Neurological Deficits. Cancers (Basel). 2022 Jan 11;14(2). doi: 10.3390/cancers14020340. PubMed PMID: 35053503; PubMed Central PMCID: PMC8774180.
84. Al-Holou WN, Suki D, Hodges TR, Everson RG, Freeman J, Ferguson SD, McCutcheon IE, Prabhu SS, Weinberg JS, Sawaya R, Lang FF. Circumferential sulcus-guided resection technique for improved outcomes of low-grade gliomas. J Neurosurg. 2022 Jan 7;:1-11. doi: 10.3171/2021.9.JNS21718. [Epub ahead of print] PubMed PMID: 34996044.
85. Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2022 Jan 5;13(1):190. doi: 10.1038/s41467-021-27820-5. PubMed PMID: 34987156; PubMed Central PMCID: PMC8733027.
86. Prinsloo S, Rosenthal DI, Garcia MK, Meng Z, Cohen L. Cross-Cultural Brain Activity Differences Between True and Sham Acupuncture for Xerostomia During Head and Neck Cancer Radiotherapy. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221101630. doi: 10.1177/15347354221101630. PubMed PMID: 35603438; PubMed Central PMCID: PMC9125604.
Publications- 2021
1. Mattogno PP, Marciano F, Catalino MP, Mattavelli D, Cocca P, Lopomo NF, Nicolai P, Laws ER Jr, Witterick I, Raza SM, Devaiah AK, Lauretti L, Olivi A, Fontanella MM, Gentili F, Doglietto F. Ergonomics in Endoscopic Transsphenoidal Surgery: A Survey of the North American Skull Base Society. J Neurol Surg B Skull Base. 2022 Jun;83(Suppl 2):e380-e385. doi: 10.1055/s-0041-1729906. eCollection 2022 Jun. PubMed PMID: 35832944; PubMed Central PMCID: PMC9272277.
2. Chen SR, Chen MM, Ene C, Lang FF, Kan P. Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors. J Neurointerv Surg. 2022 Jun;14(6):533-538. doi: 10.1136/neurintsurg-2021-018190. Epub 2021 Nov 25. PubMed PMID: 34824133.
3. Sun X, Zhai J, Sun B, Parra ER, Jiang M, Ma W, Wang J, Kang AM, Kannan K, Pandurengan R, Zhang S, Solis LM, Haymaker CL, Raso MG, Mendoza Perez J, Sahin AA, Wistuba II, Yam C, Litton JK, Yang F. Effector memory cytotoxic CD3+/CD8+/CD45RO+ T cells are predictive of good survival and a lower risk of recurrence in triple-negative breast cancer. Mod Pathol. 2022 May;35(5):601-608. doi: 10.1038/s41379-021-00973-w. Epub 2021 Nov 27. PubMed PMID: 34839351.
4. Muir M, Patel R, Traylor JI, de Almeida Bastos DC, Kamiya C, Li J, Rao G, Prabhu SS. Laser interstitial thermal therapy for newly diagnosed glioblastoma. Lasers Med Sci. 2022 Apr;37(3):1811-1820. doi: 10.1007/s10103-021-03435-6. Epub 2021 Oct 23. PubMed PMID: 34687390.
5. Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF. Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. J Neurosurg. 2022 Mar 1;136(3):757-767. doi: 10.3171/2021.3.JNS203045. Print 2022 Mar 1. PubMed PMID: 34450587.
6. Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci. 2022 Feb 23;42(8):1406-1416. doi: 10.1523/JNEUROSCI.1918-21.2021. Epub 2021 Dec 29. PubMed PMID: 34965971; PubMed Central PMCID: PMC8883848.
7. Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D. Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline. J Clin Oncol. 2022 Feb 10;40(5):492-516. doi: 10.1200/JCO.21.02314. Epub 2021 Dec 21. PubMed PMID: 34932393.
8. Abdelmeguid AS, Bell D, Roberts D, Ferrarotto R, Phan J, Su SY, Kupferman M, Raza S, DeMonte F, Hanna E. Long-Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature. Laryngoscope. 2022 Feb;132(2):290-297. doi: 10.1002/lary.29732. Epub 2021 Jul 17. Review. PubMed PMID: 34272876.
9. Ferguson SD, Fomchenko EI, Guerrieri RA, Glitza Oliva IC. Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD). Front Oncol. 2021;11:800053. doi: 10.3389/fonc.2021.800053. eCollection 2021. Review. PubMed PMID: 35096602; PubMed Central PMCID: PMC8789647.
10. Germscheid N, Cheung JPY, Neva MH, Öner FC, Kwon BK, Valacco M, Awwad W, Sciubba DM, Lewis SJ, Rhines LD, Yoon ST, Alini M, Grad S, Fisher CG, Samartzis D. Research Practices and Needs Among Spine Surgeons Worldwide. Global Spine J. 2021 Dec 6;:21925682211058158. doi: 10.1177/21925682211058158. [Epub ahead of print] PubMed PMID: 34870488.
11. Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI). 2021 Dec;4(4). doi: 10.3390/reports4040032. Epub 2021 Oct 1. PubMed PMID: 35937580; PubMed Central PMCID: PMC9352435.
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67. Sun X, Yu K, Zhou Y, Dong S, Hu W, Sun Y, Li Y, Xie J, Lee RJ, Sun F, Ma Y, Wang S, Kim BYS, Wang Y, Yang Z, Jiang W, Li Y, Teng L. Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase. ACS Appl Mater Interfaces. 2021 Apr 21;13(15):18152-18164. doi: 10.1021/acsami.1c03589. Epub 2021 Mar 25. PubMed PMID: 33764751.
68. Shin DH, Nguyen T, Ozpolat B, Lang F, Alonso M, Gomez-Manzano C, Fueyo J. Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy. J Immunother Cancer. 2021 Apr;9(4). doi: 10.1136/jitc-2020-002086. Review. PubMed PMID: 33795384; PubMed Central PMCID: PMC8021759.
69. Passer JZ, Alvarez-Breckenridge C, Rhines L, DeMonte F, Tatsui C, Raza SM. Surgical Management of Skull Base and Spine Chordomas. Curr Treat Options Oncol. 2021 Mar 20;22(5):40. doi: 10.1007/s11864-021-00838-z. Review. PubMed PMID: 33743089.
70. Ravindra VM, Karas PJ, Hartnett S, Patino I, North R, Tatsui CE, Gonda D, Schwabe A, Curry DJ. Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Palliative Rhizotomy: A Novel Technical Application. Oper Neurosurg (Hagerstown). 2021 Mar 15;20(4):413-418. doi: 10.1093/ons/opaa415. PubMed PMID: 33377153.
71. Landry JP, Schertz KL, Chiang YJ, Bhalla AD, Yi M, Keung EZ, Scally CP, Feig BW, Hunt KK, Roland CL, Guadagnolo A, Bishop AJ, Lazar AJ, Slopis JM, McCutcheon IE, Torres KE. Comparison of Cancer Prevalence in Patients With Neurofibromatosis Type 1 at an Academic Cancer Center vs in the General Population From 1985 to 2020. JAMA Netw Open. 2021 Mar 1;4(3):e210945. doi: 10.1001/jamanetworkopen.2021.0945. PubMed PMID: 33734413; PubMed Central PMCID: PMC7974640.
72. Zakaria R, Prabhu SS. Letter to the Editor Regarding "Safety Analysis of Bilateral Laser Interstitial Thermal Therapy for Treatment of Butterfly Glioma". World Neurosurg. 2021 Mar;147:236-237. doi: 10.1016/j.wneu.2020.10.161. PubMed PMID: 33685011.
73. Versteeg AL, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Weber MH, Lazary A, Boriani S, Bettegowda C, Fehlings MG, Clarke MJ, Arnold PM, Gokaslan ZL, Fisher CG. Health related quality of life outcomes following surgery and/or radiation for patients with potentially unstable spinal metastases. Spine J. 2021 Mar;21(3):492-499. doi: 10.1016/j.spinee.2020.10.017. Epub 2020 Oct 22. PubMed PMID: 33098985.
74. Rogers CM, Jones PS, Weinberg JS. Intraoperative MRI for Brain Tumors. J Neurooncol. 2021 Feb;151(3):479-490. doi: 10.1007/s11060-020-03667-6. Epub 2021 Feb 21. Review. PubMed PMID: 33611714.
75. Chen C, Lee I, Tatsui C, Elder T, Sloan AE. Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review. J Neurooncol. 2021 Feb;151(3):429-442. doi: 10.1007/s11060-020-03652-z. Epub 2021 Feb 21. Review. PubMed PMID: 33611709; PubMed Central PMCID: PMC7897607.
76. Srinivasan VM, Hadley CC, Patel AJ, Ehni BL, Weiner HL, Rao G, Lang FF, Sawaya RE, Yoshor D. The history of neurosurgery at Baylor College of Medicine. J Neurosurg. 2021 Feb 19;:1-11. doi: 10.3171/2020.7.JNS201196. [Epub ahead of print] PubMed PMID: 33607618.
77. Noll KR, Chen HS, Wefel JS, Kumar VA, Hou P, Ferguson SD, Rao G, Johnson JM, Schomer DF, Suki D, Prabhu SS, Liu HL. Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection. Neurosurgery. 2021 Feb 16;88(3):544-551. doi: 10.1093/neuros/nyaa453. PubMed PMID: 33080024; PubMed Central PMCID: PMC7884148.
78. Gao C, Wang F, Suki D, Strom E, Li J, Sawaya R, Hsu L, Raghavendra A, Tripathy D, Ibrahim NK. Effects of systemic therapy and local therapy on outcomes of 873 breast cancer patients with metastatic breast cancer to brain: MD Anderson Cancer Center experience. Int J Cancer. 2021 Feb 15;148(4):961-970. doi: 10.1002/ijc.33243. Epub 2020 Sep 11. PubMed PMID: 32748402.
79. Ma Y, Dong S, Li X, Kim BYS, Yang Z, Jiang W. Extracellular Vesicles: An Emerging Nanoplatform for Cancer Therapy. Front Oncol. 2020;10:606906. doi: 10.3389/fonc.2020.606906. eCollection 2020. Review. PubMed PMID: 33628730; PubMed Central PMCID: PMC7897670.
80. Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, Kim BYS, Kanekiyo T, Bu G. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. 2021 Feb 3;109(3):438-447.e6. doi: 10.1016/j.neuron.2020.11.019. Epub 2020 Dec 14. PubMed PMID: 33321072; PubMed Central PMCID: PMC7864888.
81. Ene CI, Fueyo J, Lang FF. Delta-24 adenoviral therapy for glioblastoma: evolution from the bench to bedside and future considerations. Neurosurg Focus. 2021 Feb;50(2):E6. doi: 10.3171/2020.11.FOCUS20853. Review. PubMed PMID: 33524949.
82. Srinivasan VM, Lang FF, Kan P. Intraarterial delivery of virotherapy for glioblastoma. Neurosurg Focus. 2021 Feb;50(2):E7. doi: 10.3171/2020.11.FOCUS20845. Review. PubMed PMID: 33524944.
83. Traylor JI, Sheppard HE, Ravikumar V, Breshears J, Raza SM, Lin CY, Patel SR, DeMonte F. Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma. Neurosurgery. 2021 Jan 13;88(2):428-436. doi: 10.1093/neuros/nyaa398. PubMed PMID: 33017025; PubMed Central PMCID: PMC7803434.
84. McCutcheon IE. Stereotactic Radiosurgery to Prevent Local Recurrence of Brain Metastasis After Surgery: Neoadjuvant Versus Adjuvant. Acta Neurochir Suppl. 2021;128:85-100. doi: 10.1007/978-3-030-69217-9_9. PubMed PMID: 34191064.
85. Mehta GU, McCutcheon IE. Stereotactic Radiosurgery for Pituitary Carcinoma. Acta Neurochir Suppl. 2021;128:43-49. doi: 10.1007/978-3-030-69217-9_5. PubMed PMID: 34191060.
86. Ahluwalia M, Ali MA, Joshi RS, Park ES, Taha B, McCutcheon I, Chiang V, Hong A, Sinclair G, Bartek J Jr, Chen CC. An integrated disease-specific graded prognostic assessment scale for melanoma: contributions of KPS, CITV, number of metastases, and BRAF mutation status. Neurooncol Adv. 2021 Jan-Dec;3(1):vdaa152. doi: 10.1093/noajnl/vdaa152. eCollection 2021 Jan-Dec. PubMed PMID: 33506199; PubMed Central PMCID: PMC7810198.
87. Ferguson SD, Hodges TR, Majd NK, Alfaro-Munoz K, Al-Holou WN, Suki D, de Groot JF, Fuller GN, Xue L, Li M, Jacobs C, Rao G, Colen RR, Xiu J, Verhaak R, Spetzler D, Khasraw M, Sawaya R, Long JP, Heimberger AB. A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram. Neurooncol Adv. 2021 Jan-Dec;3(1):vdaa146. doi: 10.1093/noajnl/vdaa146. eCollection 2021 Jan-Dec. PubMed PMID: 33426529; PubMed Central PMCID: PMC7780842.
88. Jiang W, Wang Y, Wargo JA, Lang FF, Kim BYS. Considerations for designing preclinical cancer immune nanomedicine studies. Nat Nanotechnol. 2021 Jan;16(1):6-15. doi: 10.1038/s41565-020-00817-9. Epub 2020 Dec 21. Review. PubMed PMID: 33349682; PubMed Central PMCID: PMC8103921.
89. Gates EDH, Weinberg JS, Prabhu SS, Lin JS, Hamilton J, Hazle JD, Fuller GN, Baladandayuthapani V, Fuentes DT, Schellingerhout D. Estimating Local Cellular Density in Glioma Using MR Imaging Data. AJNR Am J Neuroradiol. 2021 Jan;42(1):102-108. doi: 10.3174/ajnr.A6884. Epub 2020 Nov 26. PubMed PMID: 33243897; PubMed Central PMCID: PMC7814791.
90. Srinivasan VM, Ene C, Kerrigan BP, Lang FF. Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors. Neurosurg Clin N Am. 2021 Jan;32(1):93-104. doi: 10.1016/j.nec.2020.09.002. Epub 2020 Nov 5. Review. PubMed PMID: 33223031; PubMed Central PMCID: PMC7927773.
91. Zakaria R, Weinberg JS. Challenges Associated with Reoperation in Patients with Glioma. Neurosurg Clin N Am. 2021 Jan;32(1):129-135. doi: 10.1016/j.nec.2020.09.004. Epub 2020 Nov 5. Review. PubMed PMID: 33223021.
92. Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Feltri ML. αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia. 2021 Jan;69(1):91-108. doi: 10.1002/glia.23886. Epub 2020 Aug 3. PubMed PMID: 32744761; PubMed Central PMCID: PMC8491627.
93. Li Y, Marri T, North RY, Rhodes HR, Uhelski ML, Tatsui CE, Rhines LD, Rao G, Corrales G, Abercrombie TJ, Johansson CA, Dougherty PM. Chemotherapy-induced peripheral neuropathy in a dish: dorsal root ganglion cells treated in vitro with paclitaxel show biochemical and physiological responses parallel to that seen in vivo. Pain. 2021 Jan;162(1):84-96. doi: 10.1097/j.pain.0000000000002005. PubMed PMID: 32694383; PubMed Central PMCID: PMC7744394.
Publications- 2020
1. Breshears JD, DeMonte F, Habib A, Gidley PW, Raza SM. Management of Recurrent or Progressing Skull Base Chondrosarcomas: Predictors of Long-Term Outcomes. J Neurol Surg B Skull Base. 2021 Jul;82(Suppl 3):e155-e165. doi: 10.1055/s-0040-1701523. Epub 2020 Feb 7. PubMed PMID: 34306931; PubMed Central PMCID: PMC8289497.
2. Choi KY, Amit M, Tam S, Bell D, Phan J, Garden AS, Williams MD, Ferrarotto R, El-Naggar AK, Raza SM, DeMonte F, Kupferman ME, Hanna EY, Su SY. Clinical Implication of Diagnostic and Histopathologic Discrepancies in Sinonasal Malignancies. Laryngoscope. 2021 May;131(5):E1468-E1475. doi: 10.1002/lary.29102. Epub 2020 Sep 18. PubMed PMID: 32946597.
3. Srivatsan A, Mohanty A, Saleem Y, Srinivasan VM, Wagner K, Seeley J, Burkhardt JK, Chen SR, Johnnson JN, Kan P. Cognitive outcomes after unruptured intracranial aneurysm treatment with endovascular coiling. J Neurointerv Surg. 2021 May;13(5):430-433. doi: 10.1136/neurintsurg-2020-016362. Epub 2020 Jul 22. PubMed PMID: 32699175.
4. Versteeg AL, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Weber MH, Lazary A, Boriani S, Bettegowda C, Fehlings MG, Clarke MJ, Arnold PM, Gokaslan ZL, Fisher CG. Health related quality of life outcomes following surgery and/or radiation for patients with potentially unstable spinal metastases. Spine J. 2021 Mar;21(3):492-499. doi: 10.1016/j.spinee.2020.10.017. Epub 2020 Oct 22. PubMed PMID: 33098985.
5. Gao C, Wang F, Suki D, Strom E, Li J, Sawaya R, Hsu L, Raghavendra A, Tripathy D, Ibrahim NK. Effects of systemic therapy and local therapy on outcomes of 873 breast cancer patients with metastatic breast cancer to brain: MD Anderson Cancer Center experience. Int J Cancer. 2021 Feb 15;148(4):961-970. doi: 10.1002/ijc.33243. Epub 2020 Sep 11. PubMed PMID: 32748402.
6. Ma Y, Dong S, Li X, Kim BYS, Yang Z, Jiang W. Extracellular Vesicles: An Emerging Nanoplatform for Cancer Therapy. Front Oncol. 2020;10:606906. doi: 10.3389/fonc.2020.606906. eCollection 2020. Review. PubMed PMID: 33628730; PubMed Central PMCID: PMC7897670.
7. Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, Kim BYS, Kanekiyo T, Bu G. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. 2021 Feb 3;109(3):438-447.e6. doi: 10.1016/j.neuron.2020.11.019. Epub 2020 Dec 14. PubMed PMID: 33321072; PubMed Central PMCID: PMC7864888.
8. Ahluwalia M, Ali MA, Joshi RS, Park ES, Taha B, McCutcheon I, Chiang V, Hong A, Sinclair G, Bartek J Jr, Chen CC. An integrated disease-specific graded prognostic assessment scale for melanoma: contributions of KPS, CITV, number of metastases, and BRAF mutation status. Neurooncol Adv. 2021 Jan-Dec;3(1):vdaa152. doi: 10.1093/noajnl/vdaa152. eCollection 2021 Jan-Dec. PubMed PMID: 33506199; PubMed Central PMCID: PMC7810198.
9. Ferguson SD, Hodges TR, Majd NK, Alfaro-Munoz K, Al-Holou WN, Suki D, de Groot JF, Fuller GN, Xue L, Li M, Jacobs C, Rao G, Colen RR, Xiu J, Verhaak R, Spetzler D, Khasraw M, Sawaya R, Long JP, Heimberger AB. A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram. Neurooncol Adv. 2021 Jan-Dec;3(1):vdaa146. doi: 10.1093/noajnl/vdaa146. eCollection 2021 Jan-Dec. PubMed PMID: 33426529; PubMed Central PMCID: PMC7780842.
10. Jiang W, Wang Y, Wargo JA, Lang FF, Kim BYS. Considerations for designing preclinical cancer immune nanomedicine studies. Nat Nanotechnol. 2021 Jan;16(1):6-15. doi: 10.1038/s41565-020-00817-9. Epub 2020 Dec 21. Review. PubMed PMID: 33349682; PubMed Central PMCID: PMC8103921.
11. Gates EDH, Weinberg JS, Prabhu SS, Lin JS, Hamilton J, Hazle JD, Fuller GN, Baladandayuthapani V, Fuentes DT, Schellingerhout D. Estimating Local Cellular Density in Glioma Using MR Imaging Data. AJNR Am J Neuroradiol. 2021 Jan;42(1):102-108. doi: 10.3174/ajnr.A6884. Epub 2020 Nov 26. PubMed PMID: 33243897; PubMed Central PMCID: PMC7814791.
12. Srinivasan VM, Ene C, Kerrigan BP, Lang FF. Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors. Neurosurg Clin N Am. 2021 Jan;32(1):93-104. doi: 10.1016/j.nec.2020.09.002. Epub 2020 Nov 5. Review. PubMed PMID: 33223031; PubMed Central PMCID: PMC7927773.
13. Zakaria R, Weinberg JS. Challenges Associated with Reoperation in Patients with Glioma. Neurosurg Clin N Am. 2021 Jan;32(1):129-135. doi: 10.1016/j.nec.2020.09.004. Epub 2020 Nov 5. Review. PubMed PMID: 33223021.
14. Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Feltri ML. αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia. 2021 Jan;69(1):91-108. doi: 10.1002/glia.23886. Epub 2020 Aug 3. PubMed PMID: 32744761; PubMed Central PMCID: PMC8491627.
15. Larkin MB, Karas PJ, McGinnis JP, McCutcheon IE, Viswanathan A. Stereotactic Radiosurgery Hypophysectomy for Palliative Treatment of Refractory Cancer Pain: A Historical Review and Update. Front Oncol. 2020;10:572557. doi: 10.3389/fonc.2020.572557. eCollection 2020. Review. PubMed PMID: 33392075; PubMed Central PMCID: PMC7773820.
16. Srinivasan VM, Gumin J, Camstra KM, Collins DE, Chen MM, Shpall EJ, Parker Kerrigan BC, Johnson JN, Chen SR, Fueyo J, Gomez-Manzano C, Lang FF, Kan P. Endovascular Selective Intra-Arterial Infusion of Mesenchymal Stem Cells Loaded With Delta-24 in a Canine Model. Neurosurgery. 2020 Dec 15;88(1):E102-E113. doi: 10.1093/neuros/nyaa470. PubMed PMID: 33231254; PubMed Central PMCID: PMC7735865.
17. Bastos DCA, Vega RA, Traylor JI, Ghia AJ, Li J, Oro M, Bishop AJ, Yeboa DN, Amini B, Kumar VA, Rao G, Rhines LD, Tatsui CE. Spinal laser interstitial thermal therapy: single-center experience and outcomes in the first 120 cases. J Neurosurg Spine. 2020 Dec 11;:1-10. doi: 10.3171/2020.7.SPINE20661. [Epub ahead of print] PubMed PMID: 33307530.
18. Majd N, Waguespack SG, Janku F, Fu S, Penas-Prado M, Xu M, Alshawa A, Kamiya-Matsuoka C, Raza SM, McCutcheon IE, Naing A. Efficacy of pembrolizumab in patients with pituitary carcinoma: report of four cases from a phase II study. J Immunother Cancer. 2020 Dec;8(2). doi: 10.1136/jitc-2020-001532. PubMed PMID: 33427689; PubMed Central PMCID: PMC7757504.
19. Deng W, Wang Y, Liu X, Liu J, Wang L, Yang Z, Yang M, An Y, Tang C, Sanford NN, Kim BYS, Jiang W. Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016. JAMA Netw Open. 2020 Dec 1;3(12):e2028627. doi: 10.1001/jamanetworkopen.2020.28627. PubMed PMID: 33295975; PubMed Central PMCID: PMC7726633.
20. Lattier JM, De A, Chen Z, Morales JE, Lang FF, Huse JT, McCarty JH. Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene. 2020 Dec;39(50):7253-7264. doi: 10.1038/s41388-020-01503-9. Epub 2020 Oct 10. PubMed PMID: 33040087; PubMed Central PMCID: PMC7736299.
21. DeMonte F. Management considerations for malignant tumors of the skull base. J Neurooncol. 2020 Dec;150(3):361-365. doi: 10.1007/s11060-020-03637-y. PubMed PMID: 33034838.
22. Hafeez MU, Kan P, Srivatsan A, Moore S, Jafari M, DeLaGarza C, Hafeez K, Nascimento FA, Srinivasan VM, Burkhardt JK, Chen S, Johnson J, Saleem Y. Comparison of First-Pass Efficacy Among Four Mechanical Thrombectomy Techniques: A Single-Center Experience. World Neurosurg. 2020 Dec;144:e533-e540. doi: 10.1016/j.wneu.2020.08.209. Epub 2020 Sep 3. PubMed PMID: 32891839.
23. Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F. Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase. J Neurooncol. 2020 Dec;150(3):367-375. doi: 10.1007/s11060-020-03537-1. Epub 2020 May 18. Review. PubMed PMID: 32424573.
24. Edem I, DeMonte F, Raza SM. Advances in the management of primary bone sarcomas of the skull base. J Neurooncol. 2020 Dec;150(3):393-403. doi: 10.1007/s11060-020-03497-6. Epub 2020 Apr 18. Review. PubMed PMID: 32306199.
25. Ziu M, Kim BYS, Jiang W, Ryken T, Olson JJ. The role of radiation therapy in treatment of adults with newly diagnosed glioblastoma multiforme: a systematic review and evidence-based clinical practice guideline update. J Neurooncol. 2020 Nov;150(2):215-267. doi: 10.1007/s11060-020-03612-7. Epub 2020 Nov 19. PubMed PMID: 33215344.
26. Akdemir KC, Le VT, Kim JM, Killcoyne S, King DA, Lin YP, Tian Y, Inoue A, Amin SB, Robinson FS, Nimmakayalu M, Herrera RE, Lynn EJ, Chan K, Seth S, Klimczak LJ, Gerstung M, Gordenin DA, O'Brien J, Li L, Deribe YL, Verhaak RG, Campbell PJ, Fitzgerald R, Morrison AJ, Dixon JR, Andrew Futreal P. Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure. Nat Genet. 2020 Nov;52(11):1178-1188. doi: 10.1038/s41588-020-0708-0. Epub 2020 Oct 5. PubMed PMID: 33020667; PubMed Central PMCID: PMC8350746.
27. Shiers S, Ray PR, Wangzhou A, Sankaranarayanan I, Tatsui CE, Rhines LD, Li Y, Uhelski ML, Dougherty PM, Price TJ. ACE2 and SCARF expression in human dorsal root ganglion nociceptors: implications for SARS-CoV-2 virus neurological effects. Pain. 2020 Nov;161(11):2494-2501. doi: 10.1097/j.pain.0000000000002051. PubMed PMID: 32826754; PubMed Central PMCID: PMC7572821.
28. Diao K, Song J, Thall PF, McGinnis GJ, Boyce-Fappiano D, Amini B, Brown PD, Yeboa DN, Bishop AJ, Li J, Briere TM, Tatsui CE, Rhines LD, Chang EL, Ghia AJ. Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery. Radiother Oncol. 2020 Nov;152:49-55. doi: 10.1016/j.radonc.2020.07.050. Epub 2020 Jul 31. PubMed PMID: 32745668.
29. Parker Kerrigan BC, Ledbetter D, Kronowitz M, Phillips L, Gumin J, Hossain A, Yang J, Mendt M, Singh S, Cogdell D, Ene C, Shpall E, Lang FF. RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa132. doi: 10.1093/noajnl/vdaa132. eCollection 2020 Jan-Dec. PubMed PMID: 33241214; PubMed Central PMCID: PMC7680176.
30. Vedantam A, Vigneswaran K, Rao G, Walsh GL, Rhines LD, Tatsui CE. Use of Navigated Ultrasonic Bone Cutting Tool for En Bloc Resection of Thoracic Chondrosarcoma: Technical Report. Oper Neurosurg (Hagerstown). 2020 Oct 15;19(5):551-556. doi: 10.1093/ons/opaa239. PubMed PMID: 32745212.
31. Yosef N, Xi Y, McCarty JH. Isolation and transcriptional characterization of mouse perivascular astrocytes. PLoS One. 2020;15(10):e0240035. doi: 10.1371/journal.pone.0240035. eCollection 2020. PubMed PMID: 33031376; PubMed Central PMCID: PMC7544046.
32. Mehta GU, Raza SM. Management of Skull Base Metastases. Neurosurg Clin N Am. 2020 Oct;31(4):659-666. doi: 10.1016/j.nec.2020.06.013. Review. PubMed PMID: 32921360.
33. Giridharan N, Glitza Oliva IC, O'Brien BJ, Parker Kerrigan BC, Heimberger AB, Ferguson SD. Targeting the Tumor Microenvironment in Brain Metastasis. Neurosurg Clin N Am. 2020 Oct;31(4):641-649. doi: 10.1016/j.nec.2020.06.011. Review. PubMed PMID: 32921358.
34. Bastos DCA, Weinberg J, Kumar VA, Fuentes DT, Stafford J, Li J, Rao G, Prabhu SS. Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis. Cancer Lett. 2020 Oct 1;489:9-18. doi: 10.1016/j.canlet.2020.05.014. Epub 2020 Jun 3. Review. PubMed PMID: 32504657.
35. Chen Z, Morales JE, Avci N, Guerrero PA, Rao G, Seo JH, McCarty JH. The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development. Development. 2020 Sep 23;147(18). doi: 10.1242/dev.193094. PubMed PMID: 32895288; PubMed Central PMCID: PMC7522017.
36. Privorotskiy A, Bhavsar SP, Lang FF, Hu J, Cata JP. Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa123. doi: 10.1093/noajnl/vdaa123. eCollection 2020 Jan-Dec. Review. PubMed PMID: 33205044; PubMed Central PMCID: PMC7653686.
37. Bastola S, Pavlyukov MS, Yamashita D, Ghosh S, Cho H, Kagaya N, Zhang Z, Minata M, Lee Y, Sadahiro H, Yamaguchi S, Komarova S, Yang E, Markert J, Nabors LB, Bhat K, Lee J, Chen Q, Crossman DK, Shin-Ya K, Nam DH, Nakano I. Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy. Nat Commun. 2020 Sep 16;11(1):4660. doi: 10.1038/s41467-020-18189-y. PubMed PMID: 32938908; PubMed Central PMCID: PMC7494913.
38. Habib A, Hanasono MM, DeMonte F, Haider A, Breshears JD, Nader ME, Gidley PW, Su SY, Hanna EY, Raza SM. Surgical Management of Skull Base Osteoradionecrosis in the Cancer Population - Treatment Outcomes and Predictors of Recurrence: A Case Series. Oper Neurosurg (Hagerstown). 2020 Sep 15;19(4):364-374. doi: 10.1093/ons/opaa082. PubMed PMID: 32324878; PubMed Central PMCID: PMC7490162.
39. Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight. 2020 Sep 3;5(17). doi: 10.1172/jci.insight.134386. PubMed PMID: 32721947; PubMed Central PMCID: PMC7526457.
40. Mullarkey MP, Nehme G, Mohiuddin S, Ballester LY, Bhattacharjee MB, Trivedi D, Shah MN, Fuller GN, Zaky W, Sandberg DI. Posttreatment Maturation of Medulloblastoma into Gangliocytoma: Report of 2 Cases. Pediatr Neurosurg. 2020;55(4):222-231. doi: 10.1159/000509520. Epub 2020 Sep 3. PubMed PMID: 32882694.
41. Mericli AF, Boukovalas S, Roubaud MS, Kai-Cheng Chu C, Bird J, Lewis VO, Rhines LD, Chang EI, Adelman DM, Hanasono MM. Restoration of Spinopelvic Continuity with the Free Fibula Flap after Limb-Sparing Oncologic Resection Is Associated with a High Union Rate and Superior Functional Outcomes. Plast Reconstr Surg. 2020 Sep;146(3):650-662. doi: 10.1097/PRS.0000000000007095. PubMed PMID: 32459735.
42. Anakwenze CP, McGovern S, Taku N, Liao K, Boyce-Fappiano DR, Kamiya-Matsuoka C, Ghia A, Chung C, Trifiletti D, Ferguson SD, Li J, Yeboa DN. Association Between Facility Volume and Overall Survival for Patients with Grade II Meningioma after Gross Total Resection. World Neurosurg. 2020 Sep;141:e133-e144. doi: 10.1016/j.wneu.2020.05.030. Epub 2020 May 11. PubMed PMID: 32407910.
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