- Brain and CNS Tumor
The Brain Tumor Research Program (within the Brain Tumor Center) is a multidisciplinary program that promotes collaborations among its members for laboratory and clinical research, treatment strategies for brain, skull base, and spinal tumors. This program spans 22 departments and involves more than 100 research and clinical scientists who focus on discovering the molecular changes that drive brain and spinal tumors and developing effective new treatments for these devastating tumors. The Brain Tumor Research Program supports interactions among its diverse group by sponsoring scientific retreats, meetings, training opportunities, and collaborative projects.
Brain Tumor Research Topics
Brain cancer genetics and mechanisms of growth
- Cancer genomics to read specific molecular signatures – see Brain Cancer SPORE Project 3 and Glioblastoma Moon Shot Flagship Project 3
- Mechanisms that drive tumor origin and progression, including stem cells, tumor microenvironment, metabolism, DNA repair mechanisms and signaling pathways
- Molecular drivers of brain metastasis
New therapies for brain cancer
- Biological therapies that target glioblastoma, including oncolytic virus DNX-2401 (formerly known as Delta-24) – see Brain Cancer SPORE Project 1 and Glioblastoma Moon Shot Flagship Project 2
- Immunotherapy and immune checkpoint inhibitors for primary and metastatic brain tumors – see Brain Cancer SPORE Project 4 and Glioblastoma Moon Shot Flagship Project 1
- CNS drug development and selection, targeting tumor cell abnormalities to discover, test and develop a broad spectrum of anti-glioma agents – see Glioblastoma Moon Shot.