Areas of Research
- Brain and CNS Tumor
- Chromatin Remodelers
The Akdemir lab focuses on integrative computational analyses to advance efforts for precision cancer medicine. We are analyzing multi-omics datasets from primary human tumors, such as long-read whole genome sequencing, genome-wide chromatin organization (Hi-C) and single-cell ATAC-sequencing from common (i.e. glioblastoma) or rare (i.e. chordoma) CNS tumor types to investigate how tumor evolution shapes the organization of chromatin in cancer cells and tumor microenvironment.
We focus on the development and application of
algorithms that analyze and interpret multi-omics data from individual patients
for prospective clinical uses
Collaborations with International Scientific Organizations
The Akdemir lab is part of several international scientific organizations, such the International Cancer Genome Consortium (ICGC-PCWAG), NIH Common 4D Nucleome program, the BreakThrough Cancer Foundation.