Common brain cancer mutation changes DNA shape to drive progression, exposing therapeutic target
Many gliomas have ATRX mutations that are linked to cancer progression, but how they drive disease progression was not entirely clear
Researchers found that ATRX mutations reshape the DNA structure, creating new interactions that activate cancer-driving pathways, including the HOXA pathway
Blocking HOXA signaling slowed ATRX-deficient tumor growth in preclinical models, highlighting a promising therapeutic strategy
A new study from...
AI-guided pathology analysis can help predict immunotherapy response in rare cancers
Study utilized AI tool to measure baseline and dynamic changes in the tumor microenvironment and tumor content as patients started immunotherapy...
Lower trust in doctors and health agencies linked to gaps in awareness that HPV causes cervical cancer
U.S. adults with less trust in government health agencies or doctors were less likely to be aware that HPV causes cervical cancer, study...
Copper-induced cell death activates immune system, may help overcome immunotherapy resistance
Study identifies a new link between immune cells and a copper-induced form of cell death called cuproptosis
Findings suggest a potential strategy to overcome immunotherapy resistance
The approach was effective in slowing or stopping tumor growth in preclinical models
A preclinical study from researchers at The University of Texas MD Anderson Cancer Center, published today in Cell, details a connection between the immune system and cuproptosis...
Spatial map of bladder cancer reveals hidden tumor environments and new paths toward precision therapy
Spatial profiling of muscle-invasive bladder cancer reveals how different tumor cell states are organized within individual tumors
Bladder tumors...
Radiation therapy enhances immune environment in brain metastases, improving treatment response
Brain metastases are difficult to treat, in part due to the immunosuppressive tumor microenvironment and blood brain barrier, making immunotherapy...
Study identifies a new cause of age-related inflammation, suggesting promising treatment pathway
As cells age, they increasingly export nucleic acid structures called R-loops from the nucleus, triggering an immune response that causes...
Many cancers evolve through early bursts of chromosome changes and originate from a single cancer cell
New research shows tumors are composed of genetically diverse cancer cells that all originated from one cell rather than from multiple starting...
Novel gene therapy platform restores muscle function in models of Duchenne muscular dystrophy
Duchenne muscular dystrophy is a genetic disorder that leaves people unable to make an important protein called dystrophin, resulting in muscle...
EHA: Oral combination shows high response rates in patients with hard-to-treat acute myeloid leukemia
Relapsed or refractory acute myeloid leukemia (AML) represents one of the most challenging hematologic cancers
The menin inhibitor revumenib...
Researchers uncover how aging cells may trigger heart attacks and strokes
Some cancer treatments come with a risk of cardiovascular side effects, highlighting a need to understand underlying causes
Researchers discovered...
Early immunotherapy aids in treating potentially fatal fungal pneumonias in preclinical models
Lung infections caused by opportunistic molds can “paralyze” the immune system
Researchers tested adding immunotherapy on...