Immune cell dysfunction, not absence, defines skin cancer in immunosuppressed patients
Patients with weakened immune systems develop non-melanoma skin cancers that are more frequent, more aggressive, and more often lethal
Study finds these skin cancers are not devoid of immune cells, but the interactions between these cells are failing
The defect localizes to macrophages, which help regulate the antitumor immune response
Understanding the specific immune defects responsible may point...
Reshaping the gut microbiome can boost chemotherapy delivery to tumors
Nanoparticle-based chemotherapy is widely used but liver clearance often limits its effectiveness
The gut microbiome regulates...
Targeting a signaling pathway activated by acidic tumor environment restores treatment response to PARP inhibitors in ovarian cancer
PARP inhibitors are among the most widely used therapies for ovarian cancer, but their long-term effectiveness is limited by acquired resistance...
Epigenetic therapy shows promise against treatment-resistant AML
Next-generation epigenetic therapy showed stronger anti-leukemia activity than current standard treatments in preclinical models of acute myeloid leukemia (AML)
The drug remained effective in treatment-resistant leukemias and enhanced responses when combined with venetoclax, a standard frontline treatment
Researchers identified activation of the Hippo pathway, a natural regulator of cell growth, as a previously unrecognized...
Fasting primes gut microbiome to improve intestinal recovery after radiation treatment
Researchers identified a gut bacterium that helps prime intestinal stem cells for faster recovery
In preclinical models, short-term...
Biomarker-guided drug combinations may improve outcomes in treatment-resistant melanoma
In a preclinical study, adding a BCL2 inhibitor to standard melanoma therapy shrank tumors that had stopped responding to therapy
The study...
Study identifies a new cause of age-related inflammation, suggesting promising treatment pathway
As cells age, they increasingly export nucleic acid structures called R-loops from the nucleus, triggering an immune response that causes...