Study identifies a new cause of age-related inflammation, suggesting promising treatment pathway
As cells age, they increasingly export nucleic acid structures called R-loops from the nucleus, triggering an immune response that causes harmful inflammation
This study identified a two-protein complex involved in exporting R-loops and tested an approved drug to block this process
Results in preclinical models showed decreases in age-associated inflammation, liver damage, fat gain and muscle loss, as well as a significant...
