Blood test could monitor bone metastasis in medullary thyroid cancer
Medullary thyroid cancer often spreads to the bone in advanced disease, causing abnormal bone growth
Researchers discovered the OPG protein is linked to bone metastasis and poor survival, as it blocks bone breakdown and may explain abnormal bone growth
Targeting a common mutation reduced tumor growth and lowered levels of the OPG protein, improving outcomes in preclinical models
Findings suggest that blood OPG levels may be a way to detect...
Psilocybin prevents chemotherapy-related nerve injury and associated symptoms in preclinical models
Peripheral neuropathy is a common side effect of chemotherapy treatment, resulting in symptoms that can include numbness, painful nerve injury...
Researchers identify new way to reduce chronic nerve pain
Study reveals the BRAF protein, commonly linked to cancer, may also drive chronic nerve pain
After nerve injury, BRAF triggers changes that...
Colorectal cancer may quietly damage nerves prior to chemotherapy
Researchers at The University of Texas MD Anderson Cancer Center found that, in preclinical models of colorectal cancer, tumors can start damaging peripheral nerves before chemotherapy begins. These findings suggest tumor-related inflammation and changes to fat metabolism could damage the protective coating around nerves, disrupting signals and potentially making them more vulnerable to treatment-induced peripheral neuropathy, or nerve...
Early inflammation signal drives oral cancer development, highlights path for immunoprevention
Researchers identified immune changes in a subset of oral precancerous lesions that may be at higher risk for cancer progression
Cells with...
Immune cells use previously unknown pathway to eliminate AML
Researchers identified a previously unknown way in which T cells can attack acute myeloid leukemia (AML) cells, even when the AML cells evade...
Immune ecotypes may explain multiple myeloma outcomes missed by disease staging
Researchers mapped immune cells and their interactions across multiple myeloma and its precursor conditions
The study identified five tumor...
Microscopic colorectal cancer liver metastases harbor features that enable cancer cells to survive treatment and drive disease recurrence
Researchers...
Scientists develop new, improved method to find and isolate the strongest cancer-fighting immune cells
Isolating immune cells that can best identify and attack cancer cells is challenging because these cells are rare within tumors
Researchers...
Scientists uncover why some patients with rare leukemia may not benefit from approved targeted therapy
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive form of acute leukemia
Tagraxofusp is the first approved therapy...
Common brain cancer mutation changes DNA shape to drive progression, exposing therapeutic target
Many gliomas have ATRX mutations that are linked to cancer progression, but how they drive disease progression was not entirely clear
Researchers...
Spatial map of bladder cancer reveals hidden tumor environments and new paths toward precision therapy
Spatial profiling of muscle-invasive bladder cancer reveals how different tumor cell states are organized within individual tumors
Bladder tumors...
Radiation therapy enhances immune environment in brain metastases, improving treatment response
Brain metastases are difficult to treat, in part due to the immunosuppressive tumor microenvironment and blood brain barrier, making immunotherapy...
Many cancers evolve through early bursts of chromosome changes and originate from a single cancer cell
New research shows tumors are composed of genetically diverse cancer cells that all originated from one cell rather than from multiple starting...
Novel gene therapy platform restores muscle function in models of Duchenne muscular dystrophy
Duchenne muscular dystrophy is a genetic disorder that leaves people unable to make an important protein called dystrophin, resulting in muscle...
Researchers uncover how aging cells may trigger heart attacks and strokes
Some cancer treatments come with a risk of cardiovascular side effects, highlighting a need to understand underlying causes
Researchers discovered...
ASCO: Tile-based radiation therapy lowers risk of recurrence in brain metastases
A type of radiation treatment implanted during surgery significantly lowers risk of recurrence and may help patients with brain metastases live...
Researchers identify drivers of resistance to KRAS inhibitors in colorectal cancer
Colorectal cancer can resist KRAS inhibitors in both genetic and non-genetic ways
An early inflammation surge within days of treatment helps...
New marker aids diagnosis for aggressive prostate cancer
Aggressive prostate cancers often lose expression of traditional markers after treatment, making it hard to diagnose the tumor’s origin and...
Study may help predict response to chemotherapy in triple-negative breast cancer
Triple-negative breast cancer is treated with chemotherapy, but outcomes vary significantly among patients
Tumors have unique characteristics...
Scientists find blood-based biomarkers for inflammatory breast cancer
Inflammatory breast cancer (IBC) is highly aggressive, but there are no known genomic differences that can tell it apart from other breast cancers...
Researchers find biomarker of chemotherapy resistance in relapsed lung cancer
Standard chemotherapy treatment for small cell lung cancer (SCLC) often leads to resistance and eventual relapse
The YAP1 protein emerges in...
Researchers find potential one-two punch against triple-negative breast cancer
Many breast cancer therapies work by causing DNA replication stress, but triple-negative breast cancer (TNBC) cells survive this stress, even...
Researchers identify how enzyme affects infertility and cancer progression
Researchers used preclinical models to identify how changes to the Dicer enzyme affect both infertility and cancer progression
The study identified...
Imaging tool reveals novel insights into DNA replication stress response
Reversed DNA replication forks protect against stress to maintain genomic stability and serve as central components to cancer resistance, disease...
Novel tool more accurately predicts risk of Li-Fraumeni Syndrome
In a prospective validation study, researchers at The University of Texas MD Anderson Cancer Center demonstrated that a new mathematical model...
AACR: Novel approach prevents cancer progression, spares surgery for majority of patients with precancerous oral lesions
Precancerous oral lesions can progress to oral cancer and are typically ablated or surgically removed as a preventive measure
Direct injection...
AACR: UT MD Anderson shares latest breakthroughs in cancer research
ABSTRACTS: NG05, 1296, 1297, 1361, 1366, 2709, 3451, 4010, 4020, 4033, 4053, 6724, 6743, 6761, 6788, 6803
Researchers from The...
Researchers find new target to sensitize pancreatic tumors to immunotherapy
DPY30 acts as an epigenetic regulator to help pancreatic tumors maintain genomic stability
Targeting DPY30 triggers immune cell infiltration...
Researchers identify blood-based biomarker for cancer risk in people with Lynch Syndrome
Lynch Syndrome (LS) is a hereditary condition involving mutations in DNA mismatch repair genes
Researchers sequenced T cell receptors in blood...
Dual targeting approach improves immunotherapy response in glioblastoma
Researchers from The University of Texas MD Anderson Cancer Center have found that simultaneously blocking two key “don’t eat me signals”...
New biomarker predicts chemotherapy response in triple-negative breast cancer
Patients with triple-negative breast cancer have different treatment responses
Computational tools that predict treatment response historically...
Biomarkers predict patients with glioblastoma who will survive longer after treatment with cancer-targeting virus
Glioblastoma is a deadly brain cancer that suppresses the immune system and doesn’t respond well to available therapies
Researchers engineered...
Blood biomarker points to increased risk of brain metastasis in patients with inflammatory breast cancer
Brain metastases are a common complication of inflammatory breast cancer
High levels of soluble E-cadherin in the blood are associated with...
Researchers identify novel therapeutic target to improve recovery after nerve injury
Peripheral nerve injury reduces the ability of macrophages to clear dead or dying cells – a process known as efferocytosis – leading to chronic...
High levels of protein drive tumor immune suppression in head and neck cancer
BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment
Glutamine...
Circadian rhythms may affect risk of bacterial infection
Researchers identified an inflammation biomarker in laboratory model that predicts which individuals are at an increased risk of bacterial infection...
Promising target improves antitumor response in preclinical models of pancreatic cancer
Mitochondrial enzyme GFER is a key component in creating an immunosuppressive environment in pancreatic cancer
Inhibiting GFER along with...
Inhibiting GFER along with...
Researchers identify target to overcome treatment resistance in preclinical models of KRAS-mutant cancers
Researchers identified that RASH3D19 creates a positive feedback loop that drives hyperactivity of RAS signaling and leads to tumor growth and...
Study provides comprehensive insights into DNA language models
Researchers examined five AI models on multiple genomic tasks to see how well they performed
Models performed well overall, with each having...
DNA shape and rigidity regulate key players of gene expression
Researchers found how the INO80 protein moves nucleosomes to specific positions that are important for gene regulation and DNA replication
INO80...
Study uncovers hidden class of BRCA1 mutations and a potential way to target them
HSP90 buffers certain BRCA1 mutations, allowing them to persist in humans and promote resistance to PARP inhibitor treatments
Low-dose HSP90...
Inflammation may be responsible for driving earliest stages of lung cancer
Spatial maps of lung precancer and cancer cells at different points in development advance understanding of the earliest stages of lung cancer...
Study shows protein relieves pain hypersensitivity in preclinical models
Scientists find new role for LRRC8A protein in regulating pain
Increasing LRRC8A expression reduced pain hypersensitivity in preclinical models...
Researchers find new biomarker for improved immunotherapy response in solid tumors
Study uncovers novel relationship between TET2-mutated white blood cells and antitumor immune responses
TET2-mutated clonal hematopoiesis is...
Researchers identify enzyme involved in driving neuron differentiation
A new study from The University of Texas MD Anderson Cancer Center identified an important role for the KMT2D protein in controlling the development...
Sugary drinks may increase risk of metastasis in advanced colorectal cancer
Preclinical study provides first direct evidence linking colorectal cancer metastasis to the glucose-fructose blend found in sugar-sweetened...
Digital twin model shows promise for predicting bone metastasis treatment response in prostate and renal cancers
A new study, published in Cancer Research, highlights the development of advanced digital twin models designed to more accurately reflect...
Novel sequencing technology links DNA and RNA to provide molecular insights into breast cancer progression
Breast cancer often starts in the epithelial cells lining the milk ducts and lobules, but there are many subtypes that make it challenging...
Targeted radiation helps patients with kidney cancer delay systemic therapy
Some patients with clear cell renal cell carcinoma (ccRCC) – the most common type of kidney cancer in adults – experience oligometastatic...
Researchers identify predictive biomarkers for oral cancer metastasis
Most oral cancers start in squamous cells lining the mouth and tongue, and frequently metastasize to the lymph nodes. To identify potential...
First-in-class pan-KRAS inhibitor shows strong antitumor activity in preclinical models
KRAS is the most commonly mutated gene in cancer, but targeting the mutant protein is notoriously difficult because current therapies work...
High-dose chemotherapy improves outcomes for multiply relapsed and refractory germ-cell tumors
Testicular cancer is the most common malignancy in young men ages 15 to 35. Most patients respond well to cisplatin-based chemotherapy, with...
Triple combination therapy shows promise for treatment-resistant microsatellite stable BRAF V600E-mutant metastatic colorectal cancer
The BRAF V600E gene mutation makes colorectal cancers (CRCs) more aggressive, leading to poorer survival rates. While some CRCs with high...
Fluorescent tracer helps identify precancerous lesions in pancreatic cancer models
During surgical treatment for pancreatic cancer, pre-malignant pancreatic lesions – which can develop into pancreatic cancer – often go unnoticed...
Large-scale CRISPR screening in stomach organoids reveals gene-drug interactions
Scientists often use organoids – laboratory-grown human cell culture systems that closely mimic body organs – to gain deeper...
Final trial data from ELI-002 cancer immunotherapy vaccine reinforce promising results
In initial results from the AMPLIFY-201 trial, co-led by Shubham Pant, M.D., an immunotherapy vaccine targeting the lymph nodes showed potential...
Targeting brain-liver pathway with electronic wearables could prevent cancer-associated weight and muscle loss
Many patients with cancer develop a serious and currently incurable condition called cachexia, which is characterized by rapid weight and...
Novel drug confirms NSD2 protein as therapeutic target in lung and pancreatic cancers
Studies have shown that the NSD2 protein fuels cancer growth, particularly in difficult-to-treat cancers with KRAS mutations, suggesting it...
MDS subtype associated with poor outcomes after venetoclax-based therapy
Myelodysplastic syndromes (MDS) are a group of diseases in which the bone marrow does not produce enough healthy blood cells. The erythroid...
New biomarker and strategy identify and overcome resistance in HR+/HER2- breast cancer
CDK4/6 inhibitors are targeted therapies commonly used as first-line treatments for patients with hormone receptor-positive HER2-negative...
Study provides insights into advanced ovarian cancer tumors after treatment
Many patients with advanced ovarian cancer treated with frontline therapies still end up with clinically undetectable amounts of cancer cells...
Lorazepam significantly reduces agitation in patients with advanced cancer and delirium
Many patients with advanced cancer are significantly impacted by agitated delirium, but there are conflicting results on treating this condition...
Combining immunotherapy with bacterial injection shows promise in treatment-refractory solid tumors
Solid tumors contain areas with low oxygen levels, known as hypoxic regions, that are associated with treatment resistance, aggressive growth...
Study uncovers target to overcome resistance in ARID1A-mutant cancers
Many ovarian clear cell carcinomas (OCCCs) have mutations that inactivate the ARID1A tumor suppressor and are associated with resistance to...
Novel agent restores p53 function in p53-mutated AML
Mutations of the TP53 gene are very common in leukemias and other cancers. They are predictors of poor response to therapies and are...
Specific co-mutations in KRAS-mutant NSCLC improve treatment response
Patients with KRAS-mutant non-small cell lung cancer (NSCLC) also often have co-mutations in KEAP1 and LKB1, which are associated with problems...
New-onset diabetes may serve as an early marker of pancreatic cancer
Pancreatic cancer screening is not recommended for the general population due to its low incidence, leading to later diagnoses after...
Study uncovers potential therapeutic targets for low platelet blood disorders
Thrombocytopenia is a blood disorder characterized by low levels of blood platelets. These tiny blood cells, which help with clotting, are...
Chemotherapy drives changes to the genome and clonal architecture of blood stem cells that may increase risk of secondary malignancies
Hematopoietic stem and progenitor cells (HSPCs) – a main source of blood cell production – can accumulate DNA mutations over time, which can...
Presurgical radiation therapy may offer alternative approach to treating brain metastases
Many patients with brain metastases receive stereotactic radiation therapy (SRT) – a targeted high dose of radiation – after surgery to remove...
Injectable immunotherapy yields high remission rates in patients with B-cell ALL
Some patients with relapsed or treatment-resistant B-cell acute lymphoblastic leukemia (B-ALL) are unable to receive chemotherapy and have...
Triplet combinations improve outcomes for elderly patients with IDH-mutant AML
New targeted therapies have improved treatment options for elderly patients with IDH-mutant acute myeloid leukemia (AML) who are not eligible...
Biomarker in pancreatic cysts could predict risk of cancer progression
Pancreatic cysts are fluid-filled growths that appear on or in the pancreas and have the potential to develop into pancreatic cancer...
Heated chemotherapy improves overall survival in some patients with colorectal cancer
Some patients with advanced colorectal cancer develop metastases in the lining of the abdominal cavity, known as peritoneal metastases...
Researchers identify driver of nervous system overactivity in hypertension
The hypothalamus is an area of the brain that controls the sympathetic nervous system – which regulates the fight or flight response – by...
Researchers identify novel target for high-risk multiple myeloma
High-risk multiple myeloma is an aggressive disease in which plasma cells grow uncontrollably. It is typically resistant to treatment...
Targeting cells that form blood vessels in glioblastoma could improve treatment
The formation of new, small blood vessels – known as microvascular proliferation (MVP) – is a hallmark of glioblastoma, the most common and...
Researchers identify CREM as a critical regulator of CAR NK cell function
Chimeric antigen receptor (CAR) natural killer (NK) cells represent a promising experimental cell therapy, but the molecular mechanism regulating...
Study uncovers novel role for BRCA2, suggesting new therapeutic strategies
BRCA2, a key tumor suppressor that helps repair and protect DNA during replication, is often mutated in cancer cells. Normally, BRCA2 interacts...
Pre-surgical combination therapy shows promising results for NSCLC
Chemotherapy and immunotherapy combined with surgery is the standard treatment for patients with early-stage resectable non-small cell lung...
Study identifies a new driver and therapeutic vulnerability of bone metastasis
One of the most common sites for cancer to metastasize is the bone. Unfortunately, patients with bone metastases have a poor prognosis and...
Study uncovers epigenetic driver of bone metastasis in advanced prostate cancer
Nearly 80% of men with advanced prostate cancer develop bone metastases, leading to bone pain, fractures and a poor prognosis. Using laboratory...
Antibody treatment is safe for elderly patients with relapsed/refractory multiple myeloma
Treatment with teclistamab, a bispecific antibody, was recently approved for patients with relapsed/refractory multiple myeloma (RRMM) based...
Biomarker-guided combination therapy targets subtype of advanced prostate cancer
Castration-resistant prostate cancer (CRPC) remains one of the most lethal and treatment-resistant forms of prostate cancer, highlighting...
Sickle cell disease changes DNA structure of cells to suppress immunity
Sickle cell disease changes DNA structure of cells to suppress immunity
Patients with sickle cell disease, an inherited disorder that...
Mapping changes in lung precancer reveals TIM-3 as potential intervention target
Lung cancer is often diagnosed at late stages, making treatment challenging. To understand its early development, researchers led...
Self-advocacy may lead to less pain in older breast cancer survivors
Many older female breast cancer survivors experience persistent pain, but they are unsure how to gauge pain intensity and often have anxiety...
Novel combination provides more effective treatment option for mantle cell lymphoma
The latest treatment for mantle cell lymphoma (MCL) – an aggressive and incurable B-cell lymphoma – includes Bruton tyrosine kinase (BTK)...
Activating leukemia stem cells makes chemotherapy more effective in AML
Acute myeloid leukemia (AML) is a hard-to-treat cancer in which certain leukemia stem/progenitor cells (LSPCs) hide in the bone marrow...
Study identifies potential biomarker for treatment response in glioblastoma
Glioblastoma, the most common type of central nervous system tumor, is generally resistant to immune checkpoint blockade, highlighting a need...
Comprehensive spatial map provides insights into pancreatic cancer metastases
Pancreatic cancer is notoriously difficult to treat, resulting in a five-year survival rate of roughly 12%. Approximately half of patients...
Triplet regimen is well tolerated by patients with AML but does not improve survival outcomes
Patients with acute myeloid leukemia (AML) who have high-risk genetic changes and those with relapsed disease have poor outcomes with...
Gut microbiome impacts CAR T cell therapy responses, side effects in multiple myeloma
The gut microbiome has been linked to chimeric antigen receptor (CAR) T cell therapy response and related toxicities, but few researchers...
Pilot nursing study explores physical activity during and after hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is a vital treatment for blood cancers, but it is also an intense therapy with lengthy hospital...
CLL-derived exosomes alter body’s immune and hematopoietic systems in CLL patients
Immunosuppression, neutropenia and anemia can occur in patients with chronic lymphocytic leukemia (CLL) – a type of blood cancer that disrupts...
Agents that cause ‘copper overload’ can overcome radiotherapy resistance in preclinical models
Radiation therapy, or radiotherapy, can successfully treat multiple cancers, but some patients develop resistance to this treatment, known...
Novel blood-based biomarker identified in newly diagnosed acute myeloid leukemia
Inflammation in patients with acute myeloid leukemia (AML) can impact responses to certain treatments, underscoring a need for better methods...
Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Cancer-associated fibroblasts (CAFs) are essential...
Combination therapy shows no added survival benefit in patients with cervical cancer
Patients with intermediate-risk cervical cancer often receive chemotherapy with radiation therapy after surgery, but the added benefit of...
BCMA-directed CAR T cell therapy is safe in patients with relapsed or refractory multiple myeloma and CNS involvement
Due to the risk of associated neurotoxicities, some clinicians are hesitant to consider B-cell maturation antigen (BCMA)-directed chimeric...
Whole-slide imaging allows real-time remote diagnosis for breast cancer
Pathologists traditionally use light microscopy to evaluate stained frozen sections of lymph nodes obtained during surgery in patients...
Study provides genomic insights into treatment resistance in SMARCA4-mutant lung cancer
SMARCA4 – a gene that helps in chromatin remodeling – frequently is mutated in lung cancer, leading to immunotherapy resistance and a...
Phase II study identifies potential biomarkers in HPV-positive anal cancer
Cytotoxic chemotherapy is the standard of care for patients with unresectable and metastatic squamous cell carcinoma of the anal canal – a...
Bioinformatics chatbot can analyze large-scale cancer proteomics data
Comprehensive cancer omics initiatives like The Cancer Genome Atlas (TCGA) provide a wealth of DNA and RNA data, but little is known about...
Combination therapy yields strong long-term overall response rate in newly diagnosed acute myeloid leukemia patients
Intensive chemotherapy remains the standard treatment option for medically fit patients with newly diagnosed acute myeloid leukemia (AML)....
Study offers insights into evolutionary process driving pancreatic cancer aggressiveness
Pancreatic cancer is hard to treat because of its heterogeneity, a characteristic frequently sustained by the ability of cells to change states...
Researchers identify epigenetic biomarker for breast cancer metastatic relapse
Cancer cells that initiate metastasis at secondary sites often enter a dormant state, allowing them to evade treatment and later reawaken...
Surgery enhances immunotherapy in advanced kidney cancer
Patients with advanced solid tumors are usually ineligible for surgery. However, surgically removing the primary tumor in preclinical models...