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{ "@context": "", "@type": "MedicalCondition", "alternateName": "NF", "additionalType": [ "NF1", "NF2", "Schwannomatosis" ], "disambiguatingDescription": [ "NF1, affects around 1 out of every 3,500 births. Most NF1 patients have mild to moderate symptoms, but it is a progressive disorder that can lead to disfigurement, skeletal abnormalities and learning disabilities.", "NF2 is much rarer than NF1 and is characterized by tumors on the vestibular nerve. NF2 brings an increased risk of oth", "Schwannomatosis is also very rare. It is defined by the presence of multiple schwannomas (tumors that grow around nerves without involving the skin or other organs) everywhere in the body except on the vestibular nerve." ], "associatedAnatomy": [ "", "", "", "", "", "" ], "description": [ "Neurofibromatosis (NF) is an unpredictable, progressive disorder that causes tumors to form in the nervous system, specifically in and around nerve cells. These tumors can show up anywhere, including the brain, spinal cord, adrenal gland, eyes and muscle tissue.", "While neurofibromatosis tumors are usually benign, they can pose health risks. Some tumors can lead to disfigurement. Growths on or near the spinal cord and surrounding nerves can cause to paralysis. In about 10% of cases, these tumors become malignant cancers. For patients whose tumors pose serious health risks, early detection is key." ], "epidemiology": [ "Children with one parent with neurofibromatosis have a 50% chance of inheriting the gene and developing the disease. Individuals with the disease should get genetic counseling for themselves and for their children.", "Neurofibromatosis is caused by one of three genetic mutations that are either inherited from a parent or that seem to develop randomly in an individual. People with one of these mutations will develop the disorder. There are no steps that can prevent the disease." ], "name": "Neurofibromatosis", "relevantSpecialty": "Oncologic", "@id": "" }