As one of the world's leading leukemia programs, MD Anderson's Leukemia Center brings together internationally renowned physicians with a specialized support team to customize your care. These highly experienced experts communicate and collaborate daily, ensuring you receive comprehensive leukemia treatment.
The Leukemia Center offers a full range of the latest and most advanced treatment options, including new approaches and investigational agents that are designed to increase your chance for successful treatment. These trials offer innovative and new treatments, including targeted therapies, vaccines, immunotherapies, CAR-T cell therapies and monoclonal antibodies. The Leukemia Center also collaborates closely with the Stem Cell Transplantation and Cellular Therapy Center to coordinate stem cell transplants for patients who need that procedure.
If you are diagnosed with leukemia, your doctor will discuss the best options to treat it. This depends on several factors, including the type of leukemia, your age and your general health.
Your treatment for leukemia will be customized to your particular needs. One or more of the following therapies may be recommended to treat the cancer or help relieve symptoms.
Leukemia treatment goals
The goal of leukemia treatment is to put the disease into remission and ultimately cure the patient.
For leukemia, complete remission usually means that the patient’s bone marrow has no microscopic evidence of the disease and his or her blood counts have returned to normal. When evaluating for acute leukemia (AML and ALL) with the microscope, the pathologists are looking for immature cells, called blasts. Blasts normally make up less than 5% of healthy bone marrow. In active leukemia, the blast count is greater than 5%. Once patients with acute leukemia are in remission, they will need additional treatment to maintain the remission.
Patients who remain in continued complete remission for an extended period of time are considered cured. This means they have an extremely low chance of recurrence. The exact amount of time it takes to be considered cured differs among leukemia types, but it is typically measured in years.
Chemotherapy for leukemia
Chemotherapies are powerful drugs that kill rapidly dividing cells like cancer cells. The exact chemotherapy regimen a patient receives depends of his or her particular type of leukemia. For some types of leukemia, chemotherapy is one of the core components of treatment designed to cure the disease. In other cases, milder forms of chemotherapy alone can cure leukemia.
For AML patients, chemotherapy is given in two phases:
- Remission induction: This is an intense phase of treatment designed to kill leukemia cells in the blood and bone marrow and can require a hospital stay. The goal is to bring the cancer into remission.
- Consolidation: This phase of chemotherapy is meant to kill any remaining cancer cells that survived the induction phase.
ALL patients undergo the remission induction and consolidation phases, as well as a third chemotherapy phase, maintenance. During the maintenance phase, patients receive additional lower doses of chemotherapy over a longer period of time to try to wipe out any remaining cells.
Patients with chronic leukemia can receive chemotherapy treatment, but targeted therapies are currently more commonly used for these leukemias. These do not follow the above phases, however. Read more about chemotherapy.
Targeted therapy for leukemia
Targeted therapy is designed to stop or slow the growth of cancer by interfering with, or targeting, molecules or genes in cancer cells that help the disease survive, grow and spread. By targeting these particularly vulnerable features, the leukemia cells are ultimately eliminated. There are limited and minimal associated side effects of these treatments. Read more about targeted therapy.
Immunotherapy for leukemia
Cancer immunotherapy recruits the immune system to eliminate cancer. There are several types of immunotherapies, and each uses the immune system in a different ways. Immunotherapies for leukemia include:
- Antibody-drug conjugates: Antibody-drug conjugates use an immune molecule (antibody) that seeks and binds with cancer cells and a cancer-killing drug that is then directly delivered to those cells.
- Bi-specific monoclonal antibodies: These therapies use antibodies that seek and bind to proteins on the surface of cancer cells and to activation proteins on immune cells. By doing this, they form a bridge between these cells, triggering the immune cell to destroy the cancer cells.
- CAR T-cell therapy: In CAR-T cell therapy, patients are given T cells (a type of immune system cell) that have been engineered to recognize and attack cancer. For leukemia, CAR T-cell therapy is currently only FDA-approved for patients under age 25 with B-cell ALL. Only patients who have been treated unsuccessfully with at least two other cancer therapies are eligible. In addition to the FDA-approved treatments, there are a number of CAR T-cell therapy clinical trials currently underway at MD Anderson for patients with various forms of leukemia. Read more about CAR T-cell therapy.
Radiation therapy for leukemia
Radiation therapy uses high energy beams to kill cancer cells. Though it’s not a primary treatment for leukemia, it may be used when the disease has affected the brain and central nervous system or is likely to spread to these areas. Read more about radiation therapy.
Stem cell transplants for leukemia
A stem cell transplant may be needed for patients whose leukemia has returned or has not responded to standard treatments. It may also be recommended if the patient has a high-risk form of leukemia that would make a cure with standard treatments unlikely. This treatment can be physically challenging, so it is typically not given to patients who are older or otherwise unhealthy.
Stem cell transplantation is not a surgical procedure. It is typically done when patients are in remission. Most leukemia patients receive an allogeneic stem cell transplant, in which stem cells are taken from the blood (and on occasion the bone marrow) of a matched donor, then infused into the patient. Stem cells may also be collected from a newborn's umbilical cord and placenta and used for a cord blood transplant.
Before the transplant, the patient receives chemotherapy (or sometimes radiation therapy) to prepare the patient’s bone marrow to accept the transplanted stem cells. The donated stem cells are then given by an intravenous infusion and travel to the bone marrow. There, they grow to produce healthy stem cells, which in turn produce red and white blood cells and platelets found in blood. Read more about stem cell transplants.
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