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David I. Sandberg, M.D., F.A.A.N.S., F.A.C.S., F.A.A.P.

David I. Sandberg, M.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Neurosurgery, Division of Surgery and Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Director of Pediatric Neurosurgery and Associate Professor, University of Texas-Houston, Mischer Neuroscience Institute, and Children's Memorial Hermann Hospital, Houston, TX

Bio Statement

Sandberg is a clinical associate professor in the Department of Neurosurgery and Division of Pediatrics at MD Anderson and serves as co-director of the Pediatric Brain Tumor Program at MD Anderson Children's Cancer Hospital. Sandberg has a long-standing clinical and research interest in pediatric brain tumors, and he has developed novel treatment approaches for malignant brain tumors in children. The animal models he developed have led to a pilot clinical trial which he is directing at MD Anderson Cancer Center for local delivery of chemotherapeutic agents into the fourth ventricle in children with malignant posterior fossa tumors. Sandberg is board certified by the American Board of Neurological Surgery and the American Board of Pediatric Neurological Surgery, and he is a member of the American Society of Pediatric Neurosurgery.  He has numerous peer-reviewed publications and invited lectureships nationally and internationally.  

Education & Training

Degree-Granting Education

1993 - 1997 Johns Hopkins University School of Medicine, M.D.

Postgraduate Training

2003 - 2004     Children's Hospital Los Angeles; Los Angeles, California; Fellow in Pediatric Neurosurgery

April - May 2000     Hospital for Sick Children; Toronto, Ontario, Canada; Visiting Fellow in Pediatric Neurosurgery

1998 - 2003     Weill Medical College of Cornell University, New York Presbyterian Hospital and Memorial-Sloan Kettering Cancer Center, Resident in Neurosurgery

1997 - 1998     Weill Medical College of Cornell University, New York Presbyterian Hospital - Cornell Campus, Surgical Intern

Board Certifications

2012  Texas Medical License
2007  Certification, American Board of Pediatric Neurological Surgery
2007  Diplomate, American Board of Neurological Surgery
2004  Florida State License
2002  California State License
2000  American Board of Neurological Surgery, Primary Examination
1998  New York State License

Honors and Awards

2013  AANS International Visiting Surgeons Fellowship Sponsor for Juan Bosco Gonzalez Torres, M.D.
2010  Miami Children’s Hospital Research Institute:  Award for Excellence in Research
2002  Cornell Medical Center Alumni Council Distinguished House Staff Award
2001  Kenneth Shulman Award from AANS/CNS for best paper presented at Pediatric Neurological Surgery Section meeting
1999  AANS/CNS Resident Traveling Fellowship in Pediatric Neurosurgery
1994  National Institutes of Health, Summer Research Fellowship
1993  Phi Beta Kappa
1992  John Harvard Scholarship
1992  Samuel H. Abramson Research Fellowship
1990  Detur Prize for Academic Achievement
1990  Robert C. Byrd Honors Scholarship
1989  National Merit Scholar
1989  Valedictorian of class of 815 students, North Miami Beach Senior High School

Selected Publications

Peer-Reviewed Original Research Articles

1. Esquenazi Y, Sandberg DI, Rekate HL.  "Successful treatment of hyperphagia by resection of a hypothalamic hamartoma." J Neurosurg Pediatrics 11:630-634, 2013.

2. Ahmad F, Rosenblum MK, Chamyan G, Sandberg DI.  “Infiltrative brainstem and cerebellar neurocytoma.”  J Neurosurg Pediatrics 10(5):418-22, 2012.

3. Sandberg DI, Chamiraju P, Zoeller G, Bhatia S, Ragheb J.  “Endoscopic Choroid Plexus Coagulation in Infants with Hydranencephaly or Hydrocephalus with a Minimal Cortical Mantle.”  Pediatric Neurosurgery,  48: 6-12, 2012.

4. Sandberg DI, Peet MM, Johnson MD, Cole P, Koru-Sengul T, Luqman AW.  "Chemotherapy administration directly into the fourth ventricle in a nonhuman primate model."  J Neurosurg Pediatrics 9: 530-541, 2012.

5. Benglis Jr. D, Covington D, Bhatia R, Bhatia S, Elhammady MS, Ragheb J, Morrison G, Sandberg DI.  “Outcomes in Pediatric Patients with Chiari Malfomation Type I Followed Up Without Surgery.”  J Neurosurg Pediatrics 7:375-379, 2011.

6. Sandberg DI, Solano J, Petito CK, Mian A, Mou C, Koru-Sengul T, Gonzalez-Brito M, Padgett KR, Luqman A, Buitrago JC, Alam F, Wilkerson JR, Crandall KM, Kuluz JM.  “Safety and Pharmacokinetic Analysis of Methotrexate Administered Directly into the Fourth Ventricle in a Piglet Model.” J Neurooncol 100:397-406, 2010.

7. Zoeller GK, Brathwaite CD, Sandberg DI.  “Malignant Transformation of an Optic Pathway

8. Glioma Without Prior Radiation Therapy.”  J Neurosurg Pediatrics 5(5): 507-510, 2010.

9. Johnson J, Ragheb J, Garg R, Patten W, Sandberg DI, Bhatia S.  “Neurogenic Stunned Myocardium After Acute Hydrocephalus.” J Neurosurg Pediatrics 5(5): 428-33, 2010.

10. Ahmad F, Sandberg DI.  “Endoscopic Management of Intraventricular Brain Tumors in Pediatric Patients:  A Review of Indications, Techniques, and Outcomes.”  J Child Neurol 25(3): 359-367, 2010.

11. Sandberg DI, Crandall KM, Koru-Sengul T, Padgett KR, Landrum J, Babino D, Petito CK, Solano J, Gonzalez-Brito M, Kuluz JW.  “Pharmacokinetic Analysis of Etoposide Distribution after Administration Directly into the Fourth Ventricle in a Piglet Model.”   J Neurooncol 97 (1): 25-32, 2010.

12. Covington DB, Rosenblum MK, Brathwaite CD, Sandberg DI.  “Angiocentric Glioma-like Tumor of the Midbrain.”  Pediatr Neurosurg 45: 229-433, 2009.

13. Lin WC, Sandberg DI, Bhatia S, Johnson M, Morrison G, Ragheb J.  “Optical Spectroscopy for In-vitro Differentiation of Pediatric Neoplastic and Epileptogenic Brain Lesions.”  J Biomed Opt 14(1): 014028, 2009.

14. Sandberg DI, Heros RC.  “Influence of Protein, Red Blood Cell Count, and Surgical Site on Shunt Performance Following Aneurysmal Subarachnoid Hemorrhage.”  J Neurosurg 109 (6): 998-999, 2008.

15. Bhatia S, Ragheb J, Johnson M, Oh S, Sandberg DI, Lin WC.  “The Role of Optical Spectroscopy in Epilepsy Surgery in Children.”  Neurosurgery Focus 25(3):E24, 2008.

16. Elhammady MSA, Benglis DM, Bhatia S, Sandberg DI, Ragheb J.  “Ventriculoatrial Shunt Catheter Displacement in a Child with Partial Anomalous Pulmonary Venous Return.”  J Neurosurg Pediatrics 2:68-70, 2008.

17. Sandberg DI, Crandall KM, Petito CK, Padgett KR, Landrum J, Babino D, He D, Solano J, Gonzalez-Brito M, Kuluz JW.  “Chemotherapy Administration Directly into the Fourth Ventricle in a New Piglet Model.”  J Neurosurg Pediatrics 1: 373-380, 2008.

18. Crandall KM, Pacheco-Jacome EP, Sandberg DI.  “Delayed Presentation and Conservative Management of an Odontoid Basilar Synchondrosis Fracture in a Child.” J Neurosurg Pediatrics 1: 402-405, 2008.

19. Berry C, Sandberg DI, Hoh DJ, Krieger MD, McComb JG.  “Use of Cranial Fixation Pins in Pediatric Neurosurgery."  Neurosurgery 62: 913-919, 2008.

20. Wykoff CC, Lam BL, Brathwaite CD, Biegel JA, McKeown CA, Rosenblum MK, Allewelt HB, Sandberg DI.  “Atypical Teratoid/Rhabdoid Tumor Arising from the Third Cranial Nerve.”  J Neuro-Ophthalmology, 28: 207-211, 2008.

21. Sandberg DI.  “Endoscopic Management of Hydrocephalus in Pediatric Patients: A Review of   Indications, Techniques, and Outcomes.”  J Child Neurology 23(5): 550-560, 2008.

22. Benglis DM, Sandberg DI.  “Acute Neurological Deficit After Minor Trauma in an Infant With Achondroplasia and Cervicomendullary Compression.”  J Neurosurg ( 2 Suppl Pediatrics) 107: 152-155, 2007.

23. Sandberg DI, Navarro R, Blanch J, Ragheb J.  “Anomalous Venous Drainage Preventing Safe Posterior Fossa Decompression in Patients with Chiari Malformation Type I and Multisutural Craniosynostosis.”  J Neurosurg (4 Suppl Pediatrics) 106: 490-494, 2007.

24. Trombly R, Sandberg DI, Wolfe SA, Ragheb J.   “High-flow Orbital Arteriovenous Malformation in a child:  case report and review of current management options.” J Craniofacial Surgery 17(4): 779-782, 2006.

25. Nimmagadda A, Sandberg DI, Ragheb J.  “Spontaneous Involution of a Large Pineal Region Hemorrhagic Cyst in an Infant.”  J Neurosurg (4 Suppl Pediatrics) 104: 275-278, 2006.

26. Sandberg DI, McComb JG, Krieger MD.  “Chemical Analysis of Fluid Obtained From Intracranial Arachnoid Cysts in Pediatric Patients.” J Neurosurg (5 Suppl Pediatrics) 103: 427-432, 2005.

27. Sandberg DI, McComb JG, Krieger MD.  “Craniotomy for Fenestration of Multiloculated Hydrocephalus in Pediatric Patients.” Neurosurgery 57 (1 Suppl.):100-106, 2005.

28. Sandberg DI, Ragheb J, Dunoyer D, Bhatia S, Olavarria G, Morrison G.  “Surgical Outcomes and Seizure Control Rates After Resection of Dysembryoplastic Neuroepithelial Tumors.” Neurosurg Focus 18 (6a): E5, 2005.

29. Sandberg DI, Bilsky MH, Kushner BH, Souweidane MM, Kramer KK, Laquaglia MP, Panageas KS, Cheung NK-V.  "Treatment of Spinal Involvement in Neuroblastoma Patients."  Pediatric Neurosurgery 39: 291-298, 2003.

30. Occhiogrosso G, Edgar MA, Sandberg DI, Souweidane MM.  "Prolonged Convection-Enhanced Delivery into the Rat Brainstem."  Neurosurgery 52: 388-394, 2003.

31. Sandberg DI, Edgar MA, Souweidane MM. "Effect of Hyperosmolar Mannitol on Convection-Enhanced Delivery into the Rat Brain Stem."  J Neuro-Oncology 58: 187-192, 2002.

32. Sandberg DI, Edgar MA, Souweidane MM. "Convection-Enhanced Delivery into the Rat Brain Stem. "  J Neurosurg 96: 885-891, 2002.

33. Sandberg DI, Lamberti-Pasculli M, Drake JM, Humphreys RP, Rutka JT.  "Spontaneous Intraparenchymal Hemorrhage in Full-term Neonates."  Neurosurgery 48: 1042-1049, 2001.

34. Sandberg DI, Edgar MA, Resch L, Rutka JT, Becker LE, Souweidane MM.  "MIB-1 Staining Index of Pediatric Meningiomas."  Neurosurgery 48: 590-597, 2001.

35. Bilsky MH, Schefler AC, Sandberg DI, Dunkel IJ, Rosenblum M.  "Sclerosing Epitheliod   Fibrosarcomas Involving the Neuraxis: Report of Three Cases." Neurosurgery 47: 956-960, 2000.

36. Souweidane M, Sandberg D, Bilsky M, Gutin P.  "Endoscopic Biopsy of Tumors of the Third Ventricle." Pediatr Neurosurg 33: 132-137, 2000.

37. Sandberg DI, Bilsky MH, Souweidane MM, Bzdil J, Gutin PH.  "Ommaya Reservoirs for the Treatment of Leptomeningeal Metastases.  Neurosurgery 47: 49-55, 2000.

38. Sandberg DI, Souweidane MM.  "Hemifacial Spasm Caused by a Pilocytic Astrocytoma of the   Fourth Ventricle."  Pediatr Neurol 21: 754-756, 1999.

39. Sandberg DI, Souweidane MM.  "Endoscopic-Guided Proximal Catheter Placement in Treatment of Posterior Fossa Cysts."  Pediatr Neurosurg 30: 180-185, 1999.

40. Sandberg DI, Lavyne MH:  "Symptomatic Spinal Epidural Lipomatosis After Local Epidural Steroid Injections:  Case Report.”  Neurosurgery 45: 162-165, 1999.

41. Frucht DM, Sandberg DI, Brown MR, Gerstberger SM, Holland SM.  “IL-12-Independent Costimulation Pathways for Interferon-Gamma Production in Familial Disseminated Mycobacterium Avium Complex Infection.  Clin Immunol 91(2): 234-41, 1999.

Presentations (Peer-Reviewed):

42. Chamiraju P, Sandberg DI, Ragheb J, Bhatia S.  “Role of Endoscopic Third Ventriculostomy and Choroid Plexus Coagulation in Post-Hemorrhagic Hydrocephalus of Prematurity.”  AANS/CNS Section on Pediatric Neurological Surgery.  St. Louis, MO, 2012 (oral presentation).

43. Sandberg DI, Zoeller G, Bhatia, S, Ragheb J. "Endoscopic Choroid Plexus Coagulation in Infants with Hydranencephaly and Hydrocephalus with Minimal Cortical Mantle."  American Association of Neurological Surgery.  Miami, FL 2012 (electronic poster presentation).

44. Sandberg DI, Nair S, Khatib Z, Ragheb J, Lee V, De Angulo G.  "Non-operative Management of Solitary Eosinophilic Granulomas of the Calvarium."  American Society of Pediatric Neurosurgeons, Puerto Rico, 2012 (oral presentation).

45. Sandberg DI, Peet MM, Johnson MD, Cole P, Koru-Sengul T, Luqman AW.  "Chemotherapy Administration Directly into the Fourth Ventricle in a Non-Human Primate Model."  AANS/CNS Section on Pediatrics.  Austin, TX, 2011 (oral presentation).

46. Nair S, Sandberg DI, Ragheb J, Khatib Z, Zoeller G, Thambuswamy M, Lee V, DeAngulo G.  "Observation as a Strategy for Management of Solitary Calvarial Eosinophilic Granuloma." American Society of Pediatric Hematology Oncology.  Baltimore, MD, 2011 (poster presentation).

47. Alghamdi S, Castellano-Sanchez A, Brathwaite C, Melnick S, Sandberg D, Olavarria G, Khatib Z, Giannini C, Burger P.  "Diffuse Low Grade Leptomeningeal Glio-Neuronal Tumor Not an Oligodendrogliomatosis:  Clinico-Pathological Features of 2 Cases".  America Association of Neuropathologists, Seattle, WA, 2011 (poster presentation).

48. Benglis D, Covington DB, Bhatia R, Bhatia S, Elhammady S, Ragheb J, Morrison G, Sandberg DI.  "Outcomes in Pediatric Patients with Chiari I Malformation Treated Without Surgery."  American Association of Neurological Surgery.  Philadelphia, PA, 2010 (oral presentation).

49. Sandberg DI, Solano J, Petito CK, Mian A, Mou C, Koru-Sengul T, Gonzalez-Brito M, Padgett KR, Luqman A, Buitrago JC, Alam F, Wilkerson JR, Crandall KM, Kuluz JW.  "Safety and Pharmacokinetic Analysis After Methotrexate Administration Directly into the Fourth Ventricle in a Piglet Model."  American Association of Neurological Surgery.  Philadelphia, PA, 2010 (electronic poster).

50. Ragheb J, Bhatia S, Sandberg D, McNeil A.  "Pediatric Neurosurgery in Haiti."  American Society of Pediatric Neurosurgeons.  Kohala Coast, HI, 2009 (oral presentation).

51. Oh S, Fernald B, Bhatia S, Ragheb J, Sandberg D, Johnson M, Lin W-C.  "Differentiating Pediatric Epileptic Cortical Lesions from Normal Cortex by Using Time-Dependent Diffuse Reflectance Spectroscopy In Vivo."  International Society of Optical Engineering; Orlando, FL, 2009 (oral presentation).

52. Sandberg DI, Crandall K, Petito CK, Padgett K, Landrum J, Babino D, He D, Benglis DM, Ramirez MA, Kuluz JW.  "Distribution of Etoposide in Cerebrospinal Fluid After Infusions into the Fourth Ventricle in Piglets."  American Society of Pediatric Neurosurgeons; Cabo San Lucas, Mexico, 2008 (oral presentation); published in J Neurosurg Pediatrics: 2008, April 1(4): 354A

53. Sandberg DI, Crandall K, Petito CK, Padgett K, Landrum J, Babino D, He D, Solano J,  Gonzalez-Brito M, Kuluz JW.  "Direct Administration of Chemotherapy into the Fourth Ventricle in a Piglet Model."  AANS/CNS Section on Pediatric Neurological Surgery; Miami, FL 2007 (oral presentation).

54. Ragheb J, Bhatia S, Sandberg D, Morrison G, Lin W-C, Oh S, Fernald B.  "Fluorescence and Diffuse Reflectance Spectroscopy for Intraoperative Guidance in Pediatric Brain Surgery."   AANS/CNS Section on Pediatric Neurological Surgery; Miami, FL 2007 (oral presentation).

55. Brindle TI, Ragheb J, Bhatia S, Morrison G, Sandberg DI. " Management of Idiopathic Small Syringes in Pediatric Patients."  AANS/CNS Section on Pediatric Neurological Surgery; Miami,  FL 2007 (poster presentation).

56. Bhatia S, Ragheb J, Sandberg DI, Morrison G, Jayakar P, Fernandez A, Lin WC.  "In Vivo  Characterization of Pediatric Epileptogenic Lesions Using Optical Spectroscopy.  American Association of Neurological Surgeons.  Washington, D.C., 2007 (oral presentation).

57. Farhat H, Delgado AL, Salame J, Sandberg D, Bhatia S, Ragheb J, Zauner A.  "Safety and Efficacy of Neuroendovascular Procedures in Children."  American Association of Neurological Surgeons.  Washington, D.C., 2007 (oral presentation).

58. Crandall, K, Kuluz J, Padgett K, Landrum J, Babino D, Petito CK, He D, Solano J, Gonzalez-Brito M, Sandberg DI.  "A Novel Method of Chemotherapy Delivery to the Fourth Ventricle."   Eastern-Atlantic Student Research Forum. Miami, FL, 2007 (oral presentation).

59. Sandberg DI, Morrison G, Bhatia S, Olavarria G, Ragheb J, Duchowny M, Jayakar P, Lin W-C.   "Optical Characterization of Pediatric Brain Tumors and Epileptogenic Lesions."  AANS/CNS Section on Pediatric Neurological Surgery.  Orlando, FL, 2005 (oral presentation).

60. Berry C, Hoh DJ, Sandberg DI, Sosa IJ, Krieger MD, McComb JG.  "The Use of Cranial Fixation Pins in Pediatric Neurosurgery."  Congress of Neurological Surgeons.  Boston, MA, 2005 (oral presentation).

61. Sandberg DI, McComb JG, Krieger MD.  "Craniotomy for Multiloculated Hydrocephalus in Pediatric Patients."  AANS/CNS Section on Pediatric Neurological Surgery.  San Francisco, CA, 2004 (oral presentation).

62. Sandberg DI, McComb JG, Krieger MD.  "Chemical Analysis of Fluid Obtained From Intracranial Arachnoid Cysts in Pediatric Patients."  AANS/CNS Section on Pediatric Neurological Surgery.  San Francisco, CA, 2004 (oral presentation).

63. Heller C, Krieger MD, Sandberg DI, Oh BC, McComb JG.  "Programmable Versus Fixed-Pressure Valves for the Treatment of Hydrocephalus in Children."  AANS/CNS Section on Pediatric Neurological Surgery. San Francisco, CA, 2004 (oral presentation).

64. Sandberg DI, McComb JG, Krieger MD, Gilles FH.  "Why do arachnoid cysts enlarge?"  32nd Annual Meeting of the International Society for Pediatric Neurosurgery.  Buenos Aires, Argentina, 2004 (oral presentation).

65. Heller C, Krieger MD, Sandberg DI, Oh BC, McComb JG.  "Programmable Versus Fixed-Pressure Valves for the Treatment of Hydrocephalus in Children."  32nd Annual Meeting of the International Society for Pediatric Neurosurgery. Buenos Aires, Argentina, 2004 (oral presentation).

66. Oh BH, Krieger MD, Sandberg DI, Finlay J, McComb JG. "Neurofibromatosis 3: A Report of Patients Meeting Diagnostic Criteria for Both Neurofibromatosis 1 and 2."  International Symposium on Pediatric Neuro-Oncology.  Boston, MA 2004 (oral presentation).

67. Sandberg DI, Souweidane MM, Kushner BH,, Laquaglia MP, Bilsky MH, Kushner BH.   "Treatment of spinal involvement in neuroblastoma patients."  Congress of Neurological Surgeons.  Denver, Colorado, 2003 (oral presentation).

68. Ochiogrosso G, Sandberg D, Edgar M, Souweidane M.  "Chronic Brain Stem Infusion as a Potential Delivery System for Diffuse Pontine Gliomas: An Animal Model.”  American Association of  Neurological Surgeons.  Chicago, Illinois, 2002 (oral presentation).

69. Sandberg D, Edgar M, Souweidane M.  “Convection-Enhanced Delivery into the Rat Brain Stem: A Potential Delivery Mechanism for the Treatment of Diffuse Pontine Gliomas.”  American Association of Neurological Surgeons.  Chicago, Illinois, 2002 (oral presentation for Kenneth Shulman Award).

70. Sandberg D, Edgar M, Souweidane M.  “Convection-Enhanced Delivery into the Rat Brain Stem: A Potential Delivery Mechanism for the Treatment of Diffuse Pontine Gliomas.”  AANS/CNS Section on Pediatric Neurological Surgery.  New York, New York, 2001 (oral presentation).

71. Sandberg D, Edgar M, Souweidane M.  "Convection-Enhanced Delivery into the Brain Stem: An animal model."  Congress of Neurological Surgeons.  San Diego, California, 2001 (oral presentation).

72. Souweidane M, Sandberg D, Rutka J, Resch L, Edgar M.  "MIB-1 Staining Index of Pediatric Meningiomas."  AANS/CNS Section on Pediatric Neurological Surgery.  Atlanta, 1999. (oral presentation).

73. Souweidane M, Sandberg D, Bilsky M, Gutin P.  "Endoscopic Biopsy of Tumors of the Third Ventricle." Congress of Neurological Surgeons.  Boston, Massachusetts, 1999. (oral poster presentation).

74. Sandberg D, Bilsky M, Souweidane M, Bzdil J, Gargan-Klinger R, Gutin P.  "Ventricular Access Devices for Leptomeningeal Disease:  Techniques and Complications."  Congress of Neurological Surgeons.  Boston, Massachusetts, 1999. (poster presentation).

75. Sandberg D, Souweidane M.  "Endoscopic-Guided Proximal Catheter Placement in Treatment of Posterior Fossa Cysts."  AANS/CNS Section on Pediatric Neurological Surgery.  Indianapolis, Indiana, 1998.  (poster presentation).

76. Watts M, Sandberg D, Sills A, Bohan E, Gibbons C, Brem H.  "Chemotherapeutic Resistance Patterns of Tumor Specimens From Patients With Glioblastoma Multiforme and Glioma Cell Lines.  American Association of Neurological Surgeons.  Denver, Colorado, 1997. (poster presentation).

77. Sandberg D, Watts M, Tyler B, Brem H.  "Cytotoxicity of Taxotere in Vitro Against Human and Rat Malignant Glioma Cell Lines."  American Association of Neurological Surgeons.  Denver, Colorado, 1997.  (poster presentation)

78. Frucht DM, Yeung C, Sandberg D, Holland SM.  "Interleukin-12 Deficiency in Patients With Familial Disseminated Mycobacterium Avium Complex Infection."  Journal of Investigative Medicine Suppl.43(2): 364A, 1995.


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