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- Tumor Evolution and Metastasis Program
The goal of the Tumor Evolution and Metastasis (TEM) Program is to perform impactful research that addresses unmet medical needs and accelerates translation of discoveries into meaningful clinical impact through the study of mechanisms and factors associated with cancer dormancy escape, interactions between cancer cells and their microenvironment, and invasion and metastasis.
The goal of the Tumor Evolution and Metastasis (TEM) Program is to perform impactful research that addresses unmet medical needs and accelerates translation of discoveries into meaningful clinical impact through the study of mechanisms and factors associated with cancer dormancy escape, interactions between cancer cells and their microenvironment, and invasion and metastasis.
The three aims of the TEM program
The Tumor Evolution and Metastasis Program will utilize innovative strategies to study mechanisms governing cancer dormancy vs. invasion and metastasis to identify new anti-metastasis therapeutics for translation to patient care.
Aim 1
Cancer Dormancy
Identify tumor intrinsic and extrinsic factors that regulate cancer dormancy versus progression to invasive and metastatic cancer
Aim 2
Unraveling Interactions
Examine the co-evolution of cancer cells and their tumor microenvironment (TME) in cancer emergence, dormancy, progression, metastasis and therapeutic resistance
Aim 3
Invasion and Metastasis
Investigate mechanisms and functional drivers of cancer metastasis and design therapeutic approaches for clinical translation
Leadership
Dihua Yu, M.D., Ph.D.
TEM Co-leader
Jeffrey N. Myers, M.D., Ph.D.
TEM Co-leader
Chunru Lin, M.D., Ph.D.
TEM Associate Leader
Haoqiang Ying, M.D., Ph.D.
TEM Cancer Research Training and Education Coordination Liaison
Eleonora Dondossola, Ph.D.
TEM Community Outreach and Engagement Liaison
TEM members regularly participate in the following activities:
- Weekly interdisciplinary seminars focused on cutting-edge research in tumor evolution, metastatic mechanisms and therapeutic resistance, including the Molecular and Cellular Oncology Seminar Series and the Cancer Biology Seminar Series
- Monthly workshop supporting junior faculty through grant writing and career development
- Joint retreats with other CCSG programs (CNP, ITM, EMP) aiming to expand translational partnerships and enhance the impact of TEM program to cancer patient care
Featured Publications
Mahadevan KK, Dyevoich AM, Chen Y, Li B, Sugimoto H, Sockwell AM, McAndrews KM, Sthanam LK, Wang H, Shalapour S, Watowich SS, Kalluri R.
Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BA, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA.
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN.
CCSG Research Programs
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