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- Experimental Medicine Program
The Experimental Medicine Program (EMP) focuses on improving clinical outcomes for patients with cancer through the development of biomarker-driven novel therapeutic strategies.
The Experimental Medicine Program (EMP) focuses on improving clinical outcomes for patients with cancer through the development of biomarker-driven novel therapeutic strategies.
The three aims of the EMP program
The program brings together clinician-investigators with expertise across several solid tumor types and drug development, as well as experts in basic drug discovery, compound screening, data science, and artificial intelligence. Members of this program are at the leading edge of recent breakthroughs in oncology drug development, to include, among others, targeted therapies for RET-, KRAS-, and DNA damage repair (DDR)-aberrated cancers; cell therapies targeting mesothelin and MAGE-A4, and, more recently, antibody-drug conjugates (ADCs). With the overall goal of improving clinical outcomes for patients with cancer, especially patients for whom there are no standards-of-care or who have exhausted existing standards-of-care.
Aim 1
Innovative Clinical Trials
Hypothesis-driven trials with novel agents, combinations or modalities
Aim 2
Biomarker Discovery
Identify predictors of response and mechanisms of resistance
Aim 3
Novel Targets and Therapies
Discover new cancer vulnerabilities and develop new therapeutic strategies
Leadership
Funda Meric-Bernstam, M.D.
EMP Co-leader
John Heymach, M.D., Ph.D.
EMP Co-leader
Timothy Heffernan, Ph.D.
EMP Associate Leader
Sarina Anne Piha-Paul, M.D.
EMP Cancer Research Training and Education Coordination Liaison
Michael Overman, M.D.
EMP Community Outreach and Engagement Liaison
EMP members regularly participate in the following activities
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CCSG Experimental Medicine Program Annual Retreat
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CCSG Experimental Medicine Monthly Seminar Series
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Distinguished Seminar Series in Experimental Therapeutics
More about the Distinguished Seminar Series
Featured Publications
Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease
New England Journal of Medicine, 2021
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R.
Amaria RN, Postow M, Burton EM, Tetzlaff MT, Ross MI, Torres-Cabala CI, Glitza IC, Duan F, Milton DR, Busam K, Simpson L, McQuade JL, Wong MK, Gershenwald JE, Lee JE, Goepfert RP, Keung EZ, Fisher SB, Betof-Warner A, Shoushtari AN, Callahan M, Coit D, Bartlett EK, Bello D, Momtaz P, Nicholas C, Gu A, Zhang X, Korivi BR, Patnana M, Patel SP, Diab A, Lucci A, Prieto VG, Davies MA, Allison JP, Sharma P, Wargo JA, Ariyan C, Tawbi HA.
Skoulidis F, Araujo HA, Do MT, Qian Y, Sun X, Cobo AG, Le JT, Montesion M, Palmer R, Jahchan N, Juan JM, Min C, Yu Y, Pan X, Arbour KC, Vokes NTEM, Schmidt ST, Molkentine D, Owen DH, Memmott R, Patil PD, Marmarelis ME, Awad MM, Murray JC, Hellyer JA, Gainor JF, Dimou A, Bestvina CM, Shu CA, Riess JW, Blakely CM, Pecot CV, Mezquita L, Tabbó F, Scheffler M, Digumarthy S, Mooradian MJ, Sacher AG, Lau SCM, Saltos AN, Rotow J, Johnson RP, Liu C, Stewart T, Goldberg SB, Killam J, Walther Z, Schalper K, Davies KD, Woodcock MG, Anagnostou V, Marrone KA, Forde PM, Ricciuti B, Venkatraman D, Van Allen EM, Cummings AL, Goldman JW, Shaish H, Kier M, Katz S, Aggarwal C, Ni Y, Azok JT, Segal J, Ritterhouse L, Neal JW, Lacroix L, Elamin YY, Negrao MV, Le X, Lam VK, Lewis WE, Kemp HN, Carter BIII, Roth JAEMP, Swisher SIII, Lee R, Zhou T, Poteete A, Kong Y, Takehara T, Paula AG, Parra Cuentas ER, Behrens C, Wistuba II, Zhang J, Blumenschein GR, Gay C, Byers LA, Gibbons DL, Tsao A, Lee JJ, Bivona TG, Camidge DR, Gray JE, Leighl NB, Levy B, Brahmer JR, Garassino MC, Gandara DR, Garon EB, Rizvi NA, Scagliotti GV, Wolf J, Planchard D, Besse B, Herbst RS, Wakelee HA, Pennell NA, Shaw AT, Jänne PA, Carbone DP, Hellmann MD, Rudin CM, Albacker L, Mann H, Zhu Z, Lai Z, Stewart R, Peters S, Johnson ML, Wong KK, Huang A, Winslow MM, Rosen MJ, Winters IP, Papadimitrakopoulou VA, Cascone T, Jewsbury P, Heymach JV.
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