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The Image-Guided Interventions and Insights (III) Program was created to reflect emerging cross-disciplinary emphases of imaging as a core thematic motif.
The Image-Guided Interventions and Insights (III) Program was created to reflect emerging cross-disciplinary emphases of imaging as a core thematic motif.
The four aims of the III program
Investigational and basic research tools for spatial assessment of therapeutic efficacy and normal tissue effects in vitro, translational applications across scales, and in vivo human image-guided interventions are all examples of how imaging is emerging as a core thematic motif. The program is predicated on efforts germane to spatially focused applications, distinctive from but synergistic with systemic or semantic data-driven modeling programs. The program will improve cancer outcomes and reduce toxicities with biology-informed, image-guided therapy.
Aim 1
Quantitative Tumor Imaging
Investigate quantitative imaging of disease characterization and response
Aim 3
Personalized Image-guided Therapy
Develop and clinically evaluate personalized, adaptive, image-guided therapy
Aim 2
Image-informed Multi-scale Translation
Explore biologically informed multi-scale imaging and therapeutic design
Aim 4
Normal Tissue Injury Mitigation
Evaluate prediction, image-based quantification and mitigation of treatment-related toxicities
Leadership
Kristy K. Brock, Ph.D.
III Co-leader
Clifton David Fuller, M.D., Ph.D.
III Co-leader
Stephen Y. Lai, M.D., Ph.D.
III Associate Leader
Rebecca Howell, Ph.D.
III Cancer Research Training and Education Coordination Liaison
Lillie Lin, M.D.
III Community Outreach and Engagement Liaison
III members regularly participate in the following activities
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III Program Retreat
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III Program & Image-Guided Cancer Therapy (IGCT) Program Joint Seminar Series
Learn more about IGCT seminars
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III Program & ICGT Program Joint Workshop Series
Learn more about ICGT workshops
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IGCT and CCSG III Summer Student Showcase
Featured Publications
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers
Cancer Discovery, 2024
Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
Software-based versus visual assessment of the minimal ablative margin in patients with liver tumours undergoing percutaneous thermal ablation (COVER-ALL): a randomised phase 2 trial
Lancet Gastroenterol Hepatol, 2025
Odisio BC, Albuquerque J, Lin YM, Anderson BM, O'Connor CS, Rigaud B, Briones-Dimayuga M, Jones AK, Fellman BM, Huang SY, Kuban J, Metwalli ZA, Sheth R, Habibollahi P, Patel M, Shah KY, Cox VL, Kang HC, Morris VK, Kopetz S, Javle MM, Kaseb A, Tzeng CW, Cao HT, Newhook T, Chun YS, Vauthey JN, Gupta S, Paolucci I, Brock KK
First-in-Human Hyperpolarized MRI for Tumor Metabolism in HNSCC
JAMA Otolaryngol Head Neck Surg, 2024
Lai SY, Sandulache VC, Schellingerhout D, Fuller CD, Chen Y, Walker CM, Bankson JA
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