Research
Puduvalli Lab in action
The Puduvalli Lab is dedicated to creating innovative therapeutic strategies against brain tumors through a blend of preclinical and translational methods. With a strong emphasis on testing and preclinical development, the lab aims to discover novel therapeutic agents that can effectively address tumor heterogeneity.
Key projects within the lab concentrate on:
- Targeting heat shock response
- Protein processing
- Epigenetic modulation
- Tumor energy metabolism
These approaches aim to tackle fundamental tumor-specific processes that remain largely independent of a tumor’s genetic and epigenetic characteristics.
The lab employs a wide range of both traditional and advanced techniques for early testing, optimization and evaluation, using patient-derived xenograft (PDX) animal models as well as innovative ex vivo testing with human glioma tissues to pinpoint the most promising agents for clinical trials.
Additionally, the lab emphasizes clinical correlative research utilizing human tissue samples from glioma therapy clinical trials to analyze treatment-related changes and identify mechanisms of resistance.