Puduvalli Laboratory

Vinay K. Puduvalli, M.D.

Dr. Puduvalli is Professor and Chair of the department of Neuro-Oncology, Co-Director of the Brain Tumor Center, Co-Director of the Cancer Neuroscience Program, leader of the MD Anderson CCSG Brain Cancer Program and Co-Director of the MD Anderson NeuroHealth Initiative (NHI). Dr. Puduvalli is a physician scientist with basic, translational and clinical research interests which focus on developing new treatments for brain malignancies using targeted therapies, innovative clinical trial designs and rational combinations of anticancer agents.

His clinical expertise includes care of patients with brain and spine malignancies, as well as neurological complications of cancer. His laboratory research focuses on identifying vulnerabilities and resistance mechanisms in gliomas and targeting these with novel agents using a variety of pre-clinical models. His team has identified novel ways to target stress response and energy metabolism in gliomas to specifically target tumor cells. In a translational context, he has led several multicenter clinical studies involving epigenetic therapies and novel targeted agents.

He has also served as a mentor for students, residents, fellows and both junior and senior faculty over the past two decades. He has served in national and international collaborative projects in neuro-oncology and has been in several leadership roles in the Society for Neuro-oncology. He has also served on review boards and grant study sections for national and international grants and in advisory or consultancy roles with various patient advocacy, research and pharmaceutical partners.