Georgios Karras, Ph.D.
Areas of Research
- Genome Evolution
- Molecular Biology
- Genome Stability
- DNA Repair
- Hereditary Cancer Syndrome
Welcome to the Karras Laboratory at MD Anderson Cancer Center. We are a functional proteomics and quantitative genetics research lab. We study principles of cellular homeostasis underlying healthy aging and cancer evolution and develop approaches to utilize these principles for precision medicine.
Genetic mutations underlie the inheritance of phenotypic traits in health and disease. Yet, mutations often produce very different phenotypes depending on the genetic and environmental contexts in which they emerge. The challenge is that there are too many relevant gene-environment interactions to characterize by classical approaches, which poses a serious barrier to advancing precision medicine. Our work aims at contributing to lifting this barrier by harnessing the homeostatic processes that keep aging cells healthy. To this end, we have focused on two targetable hallmarks of longevity, PROTEIN HOMEOSTASIS and GENOME INTEGRITY, and the genetic and epigenetic mechanisms that compromise them in congenital disease and cancer.
Meet the Team
From left to right: Mélody Mazon Ph.D., Brant Gracia Ph.D., Georgios Karras Ph.D.
We are grateful for the generous funding support of our sponsors: National Cancer Institute, The University of Texas System Rising STARs, Cancer Prevention and Research Institute of Texas, the Joe and Dorothy Dorsett Brown Foundation, The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, and The University of Texas MD Anderson Cancer Center.