Karras Laboratory
Georgios Karras, Ph.D.
Principal Investigator
Areas of Research
- Epigenetics Research
- Proteomics Research
- Genome Evolution
- Molecular Biology Research
- Genome Stability Research
- DNA Repair Research
- Hereditary Cancer Syndrome Research
- Chemotherapy Research
- Genetics Research
- Biochemistry Research
Welcome to the Karras Laboratory at MD Anderson Cancer Center. We are a functional proteomics and quantitative genetics research lab. We study principles of cellular homeostasis underlying healthy aging and cancer evolution and develop approaches to utilize these principles for precision medicine.
Scroll Ahead
Research Focus
Genetic mutations underlie the inheritance of phenotypic traits in
health and disease. Yet, mutations often produce very different
phenotypes depending on the genetic and environmental contexts in
which they emerge. The challenge is that there are too many relevant
gene-environment interactions to characterize by classical approaches,
which poses a serious barrier to advancing precision medicine. Our
work aims at contributing to lifting this barrier by harnessing the
homeostatic processes that keep aging cells healthy. To this end, we
have focused on two tractable hallmarks of longevity, PROTEIN
HOMEOSTASIS and GENOME INTEGRITY, and the
genetic and epigenetic mechanisms that compromise them in congenital
disease and cancer.
Meet the Team
From left to right: Mélody Mazon, Georgios Karras, Dipak Patel, Youssef Sabha, Brant Gracia
Our Funding
We are grateful for the generous funding support of our sponsors:
National Cancer Institute, The University of Texas System Rising
STARs, Cancer Prevention and Research Institute of Texas and The
University of Texas MD Anderson Cancer Center