Selected Publications
2022
Economos, N.G., Thapar, U., Balasubramanian, N., Karras, G.I.*, and Glazer, P.M.*. An ELISA-based platform for rapid identification of structure-dependent nucleic acid-protein interactions detects novel DNA triplex interactors. JBC, In Press DOI: https://doi.org/10.1016/j.jbc.2022.102398.
* corresponding
2018
Pedley, A.M., Karras, G.I., Zhang, X., Lindquist, S., Benkovic, S.J. (2018). Role of HSP90 in the Regulation of de Novo Purine Biosynthesis. Biochemistry 2018 57(23):3217-3221 PMID:29553718
2017
Karras, G.I.*, Yi, S., Sahni, N., Fischer, M., Xie J., Vidal, M., D’Andrea A.D., Whitesell, L.* and Lindquist S. (2017). HSP90 shapes the consequences of human genetic variation. Cell 2017 Feb 23;168(5):856-866. PMCID: PMC5325763
* corresponding
2015
Sahni, N.,Yi, S., Taipale, M., Fuxman Bass, J.I., Coulombe-Huntington, J., Yang, F., Peng, J., Weile, J., Karras, G.I., Kamburov, A., Krykbaeva, I., Tucker, G., Khurana, V., Sharma, A., Liu, Y., Yachie, N., Zhong, Q., Shen, Y., Palagi, A., San-Miguel, A., Fan, C., Balcha, D., Dricot, A., Jordan, D.M., Walsh, J.M., Shah, A.A., Yang, X., Stoyanova, A., Leighton, A., Calderwood, M.A., Jacob, Y., Cusick, M.E., Salehi-Ashtiani, K., Whitesell, L.J., Sunyaev, S., Charloteaux, B., Berger, B., Hill, D.E., Barabási, A.L., Hao, T., Roth, F.P., Xia, F., Walhout, A.J.M., Lindquist, S., Vidal M., Wang, Y., Kovacs, I.A., Lam, M.H. (2015). Widespread Perturbation of Disease-Specific Macromolecular Interactions in Human Genetic Disorders. Cell. 2015 Apr 23;161(3):647-60. PMCID: PMC4441215
2014
Nicolae, C.M., Aho, E.R., Vlahos, A.H.S., Choe, K.N., De, S., Karras, G.I., Moldovan, G.L.. (2014) The ADP-ribosyltransferase PARP10/ARTD10 interacts with Proliferating Cell Nuclear Antigen (PCNA) and is required for DNA damage tolerance. J Biol Chem. 2014 May 9;289 (19):13627-37. PMCID: PMC4036367
2013
Karras, G. I., Fumasoni, M., Siensiki, G., Vanoli, F., Branzei, D., and Jentsch, S. (2013). Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell. 2013 Feb 7;49(3):536-46
2012
Taipale, M., Krykbaeva, I., Koeva, M., Kayatekin, C., Westover, K. D., Karras, G. I., Lindquist, S.. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. PMCID: PMC3894786
2010
Karras, G. I. and Jentsch, S. (2010) The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled From the Replication Fork and Is Functional Beyond S-phase. Cell. 2010 Apr 16;141(2):255-67.
2008
Moertl, S., Karras, G. I., Wismüller, T., Ahne, F., Eckardt-Schupp, F. (2008) Regulation of double-stranded DNA gap repair by the RAD6 pathway. DNA Repair (Amst). 2008 Nov 1;7(11):1893-906. Epub 2008 Sep 11.
2005
Karras, G. I., § Kustatscher, G. §, Buhecha, H. R., Allen, M. D., Pugieux, C., Sait, F., Bycroft, M. and Ladurner, A. G. (2005) The macro domain is an ADP-ribose binding module. EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19.PMCID: PMC1142602 § equal contribution