Research

Research in Molecular and Cellular Oncology is funded by multiple federal and private foundation grants. 23 peer-reviewed papers were published in the high-impact journals such as the Cell/Nature/Science (CNS) series in the past 3 years (after 2015).

1. Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural basis for the versatile and methylation-dependent binding of CTCF to DNA. Mol Cell 66(5):711-720, 2017. (PMC5542067)
   
   
2. Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X. Nucleic Acid Res 45(5):2503-2515, 2017. (PMC5389525)
   
   
3. Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SG, Park MK, Hwang JP, Billalabeitia EG, Hung MC, Song SJ, Song MS. A UBE2O-AMPK alpha axis that promotes tumor initiation and progression offers opportunities for therapy. Cancer Cell 31(2):208-224, 2017. (PMC5463996)
   
   
4. Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park P, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick G, Han L, Lin C, Yang L. A ROR1-HER3-Lnc RNA signaling axis modulates the Hippo-Yap pathway to regulate bone metastasis. Nature Cell Biol 19(2):106-119, 2017. (PMC5336186)
   
   
5. Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X. JNK1 negatively controls anti-fungal innate immunity by suppressing CD23 expression. Nature Medicine 23(3):337-346, 2017. (PMC5592785)
   
   
6. Ju HQ, Ying HY, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Hung MC, DePinho RA, Huang P, Xu RH, Chiao PJ. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in the development of pancreatic dcuctal adenocarcinoma. Nature Comm 8:14437, 2017. (PMC5333128)
   
   
7. Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK. A hypoxia-response TRAF6-ATM-H2AX signaling axis promotes HIF1 activation, turmorigenesis and metastasis. Nature Cell Biol 19(1): 38-51, 2017. (PMC5441459)
   
   
8. Lim SO, Li CW, Xia X, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Deubiquitination and stabilization of PD-L1 by CSN5. Cancer Cell 30(6):925-939, 2016. (PMC5171205)
   
   
9. Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Glycosylation and stabilization of programmed death ligand-1 suppresses T cell activity. Nature Commun 7:12632, 2016 (PMC5013604)
   
   
10. Zhang X, Li CF, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK. TRAF6 restricts p53 mitochondrial translation, apoptosis and tumor suppression. Molecular Cell 64(4): 803-814, 2016. 
    
    
11. Zhu LL, Lui TM, Xu X, Guo YH, Zhao XQ, Wang TT, Jiang YY, Xu JF, Lin X, Jia XM. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifugual innate immunity. J Exp Med 213(8): 1555-1570, 2016. (PMC4986534) 
    
    
12. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhatter R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG. ZMYND8 reads the dual histone mark H3K4me1-H3K14ac to antagonize the expression of metastasis-linked genes. Mol Cell 63(3):470-484, 2016. (PMC4975651)
    
    
13. Napoli M, Venkatanarayan A, Raulji P, Meyers BA, Norton W, Mangala LS, Sood AK, Rodriguez-Aguayo C, Lopez-Berestein G, Vin H, Duvic M, Tetzlaff MB, Curry JL, Rook AH, Abbas HA, Coarfa C, Gunarantne PH, Tsai KY, Flores ER. Delta Np63/DGCR8-dependent MicroRNAs mediate therapeutic efficacy of HDAC inhibitors in cancer. Cancer Cell 29(6): 874-888, 2016. (PMC4908836)
    
    
14. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard P, Lee GR IV, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PAPR1 phosphorylation enhances inhibitor response. Nature Med 22(2):194-201, 2016. (PMC4754671) 
    
    
15. Lin A, Lin C, Xin Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park, PK, Zhou J, Zhou Y, Hu Z, Zou Y, Mark JR, Liang H, Hung MC, Lin C, Yang L. The Link-A ncRNA activates normoxic HIF signaling in triple-negative breast cancer. Nature Cell Biology 18(2): 213-224, 2016. (PMC4791069)
    
    
16. Jung KH, Zhang J, Zhou C, Shen H, Gagea M, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Beretta L. Differentiation therapy for hepatocellular carcinoma: multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis. Hepatology 63(3):864-879, 2016. (PMC4764447)
    
    
17. Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC. Methylation of EGFR by PRMT1 regulates EGFR signaling and cetuximab response. J Clin Invest 125: 4529-4543, 2015. (PMC4665782)
    
    
18. Zhang Lin, Zhang SY, Yao J, Lowery FJ, Huang WC, Zhang CY, Wang H, Palmieri D, Zhang Q, Cheerathodi M, McCarty JH, Huang SY, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527(7576):100-104, 2015. (PMC4791069)
    
    
19. Fang L, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, Wang J, Lee MH. ERK2-Dependent phosphorylation of CSN6 Is critical in colorectal cancer development. Cancer Cell 28(2):183-197, 2015. (PMC4560098)
    
    
20. Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nature Commun 6:7530, 2015. (PMC4507299)
    
    
21. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell 27(2):177-192, 2015. (PMC4325275)
    
    
22. Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25(2):225-236, 2015. (PMID:25601159)
    
    
23. Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ER. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517(7536):626-630, 2015. (PMC4312210)