Molecular & Cellular Oncology
Dihua Yu, M.D., Ph.D.
Department Chair ad interim
The Department of Molecular and Cellular Oncology (MCO) mission is to enable and apply basic research excellence to contribute to ending cancer significantly. The department’s oncology-driven research focuses on fundamental mechanistic discoveries and their translation to humans. As a basic science department at The University of Texas MD Anderson Cancer Center, MCO strives to enhance basic research excellence by establishing a robust research group focused on the molecular and cellular aspects of cancer research, particularly in signaling pathways and crosstalk between tumor and tumor microenvironment in tumor initiation, progression and metastasis, and resistance to various therapies. MCO hosts MD Anderson's Functional Genomics Core with the support of the Cancer Center Supporting Grant (CCSG). In addition, MCO faculty are core members of the Cancer Biology and Metastasis Program of CCSG, rated “exceptional” in the last competing renewal.
MCO has ten tenured or tenure-track faculty members, and all have established vibrant research portfolios and productive collaborations with faculty, including clinical colleagues at MD Anderson. MCO faculty are well funded with active R01, R35, DoD grants, SPORE, CPRIT MIRA, and CPRIT IIRA grants, and funding from various other agencies. All faculty members commit to educating and providing high-quality training to cultivate next-generation scientists and actively participate in various educational programs including GSBS Ph.D. programs in Cancer Biology, Genetics & Epigenetics, Immunology, and Biochemistry & Cell Biology. In addition, MCO faculty serve as a mentor in training programs supported by NIH or CPRIT.
Pictured in header: in mouse brain, astrocytes (GFAP: green) are infected with astrocyte-specific Cre adenovirus (Cre: red.) (Nuculear staining: blue)
Research focus
Disease focuses: Breast cancer, ovarian cancer, pancreatic cancer, liver cancer, lung cancer, soft tissue sarcoma, autoimmune & congenital diseases
Research interests: Metastasis (including brain), cancer prevention, DNA-repaired pathways, tumor and immune microenvironment, microbiome, cancer metabolism, targeted therapy (structure based, lncRNA), epigenetics and genetics, inflammatory pathways and apoptosis, immunotherapy.
Spotlight
Dr. Dihua Yu's paper titled "Allergic mediator histamine confers immunotherapy resistance in cancer patients via histamine receptor 1 on macrophage" has been selected to enter STAT Madness - an online bracket competition to recognize the top discoveries in biomedicine and advanced to the quarterfinal.
Dr. Yajuan Li has been selected as an MD Anderson 2021 STAT Wunderkind. As a postdoctoral fellow, Li zeroed in on determining the functions of long noncoding RNAs. One of them, she discovered, could be particularly useful for treating an inherited genetic disease called phenylketonuria, or PKU. Click to learn more.
Five publications selected by CSO for the Wall of Science (Q4 FY21-FY22)
- Dr. Dihua Yu, Cancer Cell
- Dr. Min Sup Song, Cell Metabolism
- Drs. John Tainer and Chi-Lin Tsai, Molecular Cell
- Drs. John Tainer and Zamal Ahmed. Sciences Advances
- Drs. Chunru Lin and Liuqing Yang, Science
Dr. Chunru Lin is one of six recipients of the FY21 Faculty Scholar Award, click to see presentation.
Mei-Kuang Chen, Ph.D., (Mentor: Dr. Dihua Yu) selected for 2022 AACR-Doreen J. Putrah Cancer Research Foundation Scholar-in-Training Award
Zhou Jiang, Ph.D. (mentor: Dr. Dihua Yu) is one of the recipients of the 2022 Harold C. and Mary L. Dailey Endowment Fellowship ($2,000)
Dr. Yongkun Wei, assistant professor in Dr. Haoqiang Ying's group, is an awardee of 2022-2023 Career Enhancement Program (CEP) of GI Cancer SPORE. 06/01/2022-05/31/2023, $50,000
Two MCO trainees obtained an endowed fellowship in FY21 cycle.
- Arseniy Yuzhalin, PhD, Odyssey Postdoc Fellow (mentor: Dr. Dihua Yu)—2021 Harold C. and Mary L. Dailey Endowment Fellowship ($2,000)
- Chunxiao Liu, PhD, first author in J Hepatology published in April 2021 (mentor: Dr. Dihua Yu)—2021 Harold C. and Mary L. Dailey Endowment Fellowship ($2,000)
Dr. Arseniy Yuzhalin (Odyssey Postdoc Fellow, mentor: Dr. Dihua Yu), PI: FY2021 DoD CDMRP BCRP Breakthrough Award BC210402 -Funding Level 1 “Targeting the Glia-Induced CDK5 Expression That Enforces Antigenic Escape of Brain Metastasis”, impact score 1.8, recommended for funding, $729,000 total cost for 36 months.
Dr. Suet Ying Kwan, an instructor in Dr. Beretta’s group, obtained HCC SPORE CEP Award. 09/01/2021-08/31/2021, $50000.
AACR interview: Yuan Zhang (presenter, postdoctoral), Jinyang Wang, Yi Xiao, Xiangliang Yuan, Ping Li, Yimin Duan, Victoria L Seewaldt, Dihua Yu. Title: Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Interviewed by Alexis Hyams of Oncology Learning Network and the interview was posted in MD Anderson Cancer Center News on April 29, 2021. Learn more.
New faces
Hao-Nien Chen
GSBS Student
Mentor: Dihua Yu, M.D., Ph.D.
Ahmed Eman
GSBS Student
Mentor: John Tainer, Ph.D.
Sarah Faraone
Research Assistant I
Lab: Laura Beretta, Ph.D.
Jian Gao
Postdoctoral Fellow
Mentor: Chunru Lin, Ph.D.
Pengju Gong
GSBS Student
Mentor:
Chunru Lin, Ph.D.
Chalmas Leonard, Jr
Senior Administrative Assistant
Yunhai Li
Postdoctoral Fellow
Mentor: Dihua Yu, M.D., Ph.D.
Monghui Liu
Postdoctoral Fellow
Mentor: Dr. Haoqiang Ying, M.D., Ph.D.
Antoinette Martin
Accounting Specialist
Phuoc Nguyen
GSBS Student
Mentor: Haoqiang Ying, M.D., Ph.D.
Kaysie Slayton
Senior Administrative Assistant
Education & Training
Our programs
In addition to UT Health Graduate Student of Biomedical Sciences (GSBS) programs listed below, MCO faculty serve as a mentors in NIH T32 and CPRIT training programs. MCO faculty also host a myriad of high school and undergraduate students through the MD Anderson Summer Research Programs.
Cancer Biology Program
The Cancer Biology Program offers a graduate program of study and research leading to a Ph.D. degree from the Graduate School of Biomedical Sciences. The program provides training in all aspects of cancer biology, including tumor/host interactions, metastasis and invasion, tumor cell biology and biochemistry, tumor heterogeneity, cell surfaces, cancer genetics, retroviruses, gene regulation and development.
In addition to the interdisciplinary and multidisciplinary training approaches taught through formal courses, laboratory research experience and exposure to clinical problems, the CBP offers diverse educational activities and services to students, which include: student seminar series, social events to get to know faculty members and other students, new student orientation, which includes setting up mentoring resources participation in scientific conferences at the location and national level.
Immunology Graduate Program
The Immunology Graduate Program is designed to provide high-quality, comprehensive education and research training in the exciting field of immunology, allowing graduates to successfully pursue careers as independent investigators in academia or industry.
Genetics and Epigenetics Program
The Genetics & Epigenetics (G&E) Program is a research-oriented PhD and MS program at The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. Research in G&E labs is broadly focused on the fundamental genetic, epigenetic, and genomic mechanisms that control cell growth and differentiation, and that cause cancer and other human diseases.
Biochemistry and Cell Biology Program
The Biochemistry and Cell Biology (BCB) Graduate Program is a rigorous, interdisciplinary program that focuses on understanding fundamental biological, biochemical and molecular underpinnings of normal cellular and organ function, and how these mechanisms affect normal and abnormal (disease) biological function.