Researchers find potential one-two punch against triple-negative breast cancer
Many breast cancer therapies work by causing DNA replication stress, but triple-negative breast cancer (TNBC) cells survive this stress, even at high levels
TNBC cells overexpress an enzyme, RNase H2, that helps them survive the DNA damage caused by replication stress
In this preclinical study, blocking RNase H2 directly damaged cancer cells and also activated the immune system, making this a promising therapeutic approach
Researchers...
