Publications
Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M,Weinstein JN, Lorenzi PL. Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer. Metabolites. 2019 Jan 9;9(1). pii: E10. doi:10.3390/metabo9010010. PubMed PMID: 30634463.
Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X,Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y,Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL,DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR.Functional Genomics Reveals Synthetic Lethality between PhosphogluconateDehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 Jan8;26(2):469-482.e5. doi: 10.1016/j.celrep.2018.12.043. PubMed PMID: 30625329.
Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL,Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, AndersenJB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P,Cherniack AD, Deng C, Resar L; Cancer Genome Atlas Research Network, WeinsteinJN, Mishra L, Akbani R. A Pan-Cancer Analysis Reveals High-Frequency GeneticAlterations in Mediators of Signaling by the TGF-β Superfamily. Cell Syst. 2018Oct 24;7(4):422-437.e7. doi: 10.1016/j.cels.2018.08.010. Epub 2018 Sep 26. PubMedPMID: 30268436.
Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T,Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, UngewissC, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE,Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV,Qin FX, Gibbons DL. CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade. Cancer Discov. 2018 Sep;8(9):1156-1175. doi:10.1158/2159-8290.CD-17-1033. Epub 2018 Jul 16. PubMed PMID: 30012853; PubMedCentral PMCID: PMC6205194.
Sen N, Cross AM, Lorenzi PL, Khan J, Gryder BE, Kim S, Caplen NJ. EWS-FLI1reprograms the metabolism of Ewing sarcoma cells via positive regulation ofglutamine import and serine-glycine biosynthesis. Mol Carcinog. 2018Oct;57(10):1342-1357. doi: 10.1002/mc.22849. Epub 2018 Jun 19. PubMed PMID:29873416; PubMed Central PMCID: PMC6175245.
Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, GuoW, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z.EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3KActivation. Mol Cell. 2018 Apr 19;70(2):197-210.e7. doi:10.1016/j.molcel.2018.03.018. PubMed PMID: 29677490; PubMed Central PMCID:PMC6114939.
Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L,Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z,Marchand C, Weinstein JN; Cancer Genome Atlas Research Network, Bathe OF, LiangH. Molecular Characterization and Clinical Relevance of Metabolic ExpressionSubtypes in Human Cancers. Cell Rep. 2018 Apr 3;23(1):255-269.e4. doi:10.1016/j.celrep.2018.03.077. PubMed PMID: 29617665; PubMed Central PMCID:PMC5916795.
Qian X, Li X, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation InhibitsNucleotide Synthesis in Response to Energy Stress. Cancer Discov. 2018Jan;8(1):94-107. doi: 10.1158/2159-8290.CD-17-0712. Epub 2017 Oct 26. PubMedPMID: 29074724; PubMed Central PMCID: PMC5760453.
Horvath TD, Dagan S, Lorenzi PL, Hawke DH, Scaraffia PY. Positional stableisotope tracer analysis reveals carbon routes during ammonia metabolism of Aedes aegypti mosquitoes. FASEB J. 2018 Jan;32(1):466-477. doi: 10.1096/fj.201700657R. Epub 2017 Sep 25. PubMed PMID: 28970248; PubMed Central PMCID: PMC5731135.
Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z,Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB. A murine preclinical syngeneictransplantation model for breast cancer precision medicine. Sci Adv. 2017 Apr19;3(4):e1600957. doi: 10.1126/sciadv.1600957. eCollection 2017 Apr. PubMed PMID:28439535; PubMed Central PMCID: PMC5397135.
Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y, Allen JE, Wang Z, Ma W, Lee HC, Orlowski R, Sarbassov dosD, Lorenzi PL, Huang X, Neelapu SS, McDonnell T, Miranda RN, Wang M, KantarjianH, Konopleva M, Davis RE, Andreeff M. ATF4 induction through an atypicalintegrated stress response to ONC201 triggers p53-independent apoptosis inhematological malignancies. Sci Signal. 2016 Feb 16;9(415):ra17. doi:10.1126/scisignal.aac4380. PubMed PMID: 26884599; PubMed Central PMCID:PMC4815038.
Klionsky DJ, Abdelmohsen K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rdedition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez,Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.
Anishkin A, Vanegas JM, Rogers DM, Lorenzi PL, Chan WK, Purwaha P, Weinstein JN, Sukharev S, Rempe SB. Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase. J Mol Biol. 2015 Aug 28;427(17):2867-85. doi:10.1016/j.jmb.2015.06.017. Epub 2015 Jul 2. PubMed PMID: 26142822.
Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R,Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD,Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W,Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ,McGuire SE, Flores ER, Sood AK, Mills GB. Copy number gain of hsa-miR-569 at3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. CancerCell. 2014 Dec 8;26(6):863-879. doi: 10.1016/j.ccell.2014.10.010. PubMed PMID:25490449; PubMed Central PMCID: PMC4261159.
Purwaha P, Lorenzi PL, Silva LP, Hawke DH, Weinstein JN. Targeted metabolomicanalysis of amino acid response to L-asparaginase in adherent cells.Metabolomics. 2014;10(5):909-919. Epub 2014 Feb 7. PubMed PMID: 25177232; PubMed Central PMCID: PMC4145215.
Lorenzi PL, Claerhout S, Mills GB, Weinstein JN. A curated census ofautophagy-modulating proteins and small molecules: candidate targets for cancertherapy. Autophagy. 2014 Jul;10(7):1316-26. doi: 10.4161/auto.28773. Epub 2014May 12. PubMed PMID: 24906121; PubMed Central PMCID: PMC4203555.
Purwaha P, Silva LP, Hawke DH, Weinstein JN, Lorenzi PL. An artifact inLC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization topyroglutamic acid. Anal Chem. 2014 Jun 17;86(12):5633-7. doi: 10.1021/ac501451v. Epub 2014 Jun 5. PubMed PMID: 24892977; PubMed Central PMCID: PMC4063328.
Chan WK, Lorenzi PL, Anishkin A, Purwaha P, Rogers DM, Sukharev S, Rempe SB, Weinstein JN. The glutaminase activity of L-asparaginase is not required foranticancer activity against ASNS-negative cells. Blood. 2014 Jun5;123(23):3596-606. doi: 10.1182/blood-2013-10-535112. Epub 2014 Mar 21. PubMedPMID: 24659632; PubMed Central PMCID: PMC4047499.
Cancer Genome Atlas Research Network. Comprehensive molecularcharacterization of urothelial bladder carcinoma. Nature. 2014 Mar20;507(7492):315-22. doi: 10.1038/nature12965. Epub 2014 Jan 29. PubMed PMID:24476821; PubMed Central PMCID: PMC3962515.
Weinstein JN, Lorenzi PL. Cancer: Discrepancies in drug sensitivity. Nature. 2013 Dec 19;504(7480):381-3. doi: 10.1038/nature12839. Epub 2013 Nov 27. PubMedPMID: 24284624.
Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB,Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct;45(10):1113-20.doi: 10.1038/ng.2764. PubMed PMID: 24071849; PubMed Central PMCID: PMC3919969.
Silva LP, Lorenzi PL, Purwaha P, Yong V, Hawke DH, Weinstein JN. Measurement of DNA concentration as a normalization strategy for metabolomic data fromadherent cell lines. Anal Chem. 2013 Oct 15;85(20):9536-42. doi:10.1021/ac401559v. Epub 2013 Oct 2. PubMed PMID: 24011029; PubMed Central PMCID: PMC3868625.
Dufour E, Gay F, Aguera K, Scoazec JY, Horand F, Lorenzi PL, Godfrin Y.Pancreatic tumor sensitivity to plasma L-asparagine starvation. Pancreas. 2012Aug;41(6):940-8. doi: 10.1097/MPA.0b013e318247d903. PubMed PMID: 22513289.
Claerhout S, Lorenzi PL, Weinstein JN, Mills GB. MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY. Drugs Future. 2011;36(12). doi:10.1358/dof.2011.036.12.1711892. PubMed PMID: 25419038; PubMed Central PMCID:PMC4239665.
Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Cerna D, Tropea JE, Onda A, Zoppoli G, Kondapaka S, Zhang G, Caplen NJ, Cardellina JH 2nd, Yoo SS,Monks A, Self C, Waugh DS, Shoemaker RH, Pommier Y. Cellular inhibition ofcheckpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by thenovel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid{4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009Dec;331(3):816-26. doi: 10.1124/jpet.109.154997. Epub 2009 Sep 9. PubMed PMID:19741151; PubMed Central PMCID: PMC2784710.
Lorenzi PL, Reinhold WC, Varma S, Hutchinson AA, Pommier Y, Chanock SJ,Weinstein JN. DNA fingerprinting of the NCI-60 cell line panel. Mol Cancer Ther. 2009 Apr;8(4):713-24. doi: 10.1158/1535-7163.MCT-08-0921. PubMed PMID: 19372543; PubMed Central PMCID: PMC4020356.
Lorenzi PL, Weinstein JN. Asparagine synthetase: a new potential biomarker inovarian cancer. Drug News Perspect. 2009 Jan-Feb;22(1):61-4. doi:10.1358/dnp.2009.22.1.1303820. Review. PubMed PMID: 19209300; PubMed CentralPMCID: PMC4096155.
Lorenzi PL, Llamas J, Gunsior M, Ozbun L, Reinhold WC, Varma S, Ji H, Kim H, Hutchinson AA, Kohn EC, Goldsmith PK, Birrer MJ, Weinstein JN. Asparaginesynthetase is a predictive biomarker of L-asparaginase activity in ovarian cancercell lines. Mol Cancer Ther. 2008 Oct;7(10):3123-8. doi:10.1158/1535-7163.MCT-08-0589. PubMed PMID: 18852115; PubMed Central PMCID:PMC4123961.
Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, AladjemMI, Goldstein DJ, Weinstein JN, Pommier Y. Nonclassic functions of humantopoisomerase I: genome-wide and pharmacologic analyses. Cancer Res. 2007 Sep15;67(18):8752-61. PubMed PMID: 17875716.
Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, Liu CG, Reinhold W,Lorenzi PL, Kaldjian EP, Croce CM, Weinstein JN, Sadee W. MicroRNA expressionprofiles for the NCI-60 cancer cell panel. Mol Cancer Ther. 2007May;6(5):1483-91. Epub 2007 May 4. PubMed PMID: 17483436.
Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ. Multiplexing siRNAs tocompress RNAi-based screen size in human cells. Nucleic Acids Res.2007;35(8):e57. Epub 2007 Mar 28. PubMed PMID: 17392344; PubMed Central PMCID:PMC1885663.
Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ,Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD,Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Asparagine synthetase as acausal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.Mol Cancer Ther. 2006 Nov;5(11):2613-23. Epub 2006 Nov 6. PubMed PMID: 17088436.
Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, AmidonGL. N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolizethe antiviral nucleoside2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metab Dispos.2006 Jun;34(6):1070-7. Epub 2006 Mar 24. PubMed PMID: 16565170.
Landowski CP, Lorenzi PL, Song X, Amidon GL. Nucleoside ester prodrugsubstrate specificity of liver carboxylesterase. J Pharmacol Exp Ther. 2006Feb;316(2):572-80. Epub 2005 Oct 13. PubMed PMID: 16223870.
Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidicbond metabolism. Pharm Res. 2005 Sep;22(9):1510-8. Epub 2005 Aug 24. PubMed PMID:16132363.
Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS,Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolicstability in vitro and in vivo. J Pharmacol Exp Ther. 2005 Aug;314(2):883-90.Epub 2005 May 18. PubMed PMID: 15901797.
Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL. Amino acidester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion,metabolic bioevasion, and hPEPT1-mediated transport. Mol Pharm. 2005Mar-Apr;2(2):157-67. PubMed PMID: 15804190.
Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Amino acidester prodrugs of the antiviral agent2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potentialsubstrates of hPEPT1 transporter. J Med Chem. 2005 Feb 24;48(4):1274-7. PubMedPMID: 15715497.