Orlowski Laboratory
Robert Orlowski, M.D., Ph.D.
Principal Investigator
Areas of Research
- Myeloma
- Lymphoma
- Immunotherapy
- Targeted Therapy
- Single-Cell Genomics
- Computational Biology
- CRISPR Screens
- Tumor Microenvironment
The Orlowski Lab investigates the biology, immune microenvironment and therapeutic vulnerabilities of plasma cell disorders, including multiple myeloma and its precursor states such as monoclonal gammopathy of unknown significance (MGUS) and smoldering multiple myeloma. Using integrated approaches that combine genomics, transcriptomics, functional assays and clinical datasets, the lab seeks to understand mechanisms of disease initiation, progression and treatment resistance. A major focus is the study of minimal residual disease (MRD) and the immune programs that enable malignant plasma cells to persist after therapy. These efforts aim to identify biomarkers, improve risk stratification and develop novel therapeutic strategies that translate directly into improved outcomes for patients.
