Publications

2021

Lei G, Zhuang L, Gan B. mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential. BioEssays (2021), e2100093. https://doi.org/10.1002/bies.202100093

Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. Journal of Genetics and Genomics (2021), https://doi.org/10.1016/j.jgg.2021.05.003.

Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, Das M, Fang B, Poyurovsky MV, Gan B. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. ISCIENCE (2021), doi: https://doi.org/10.1016/j.isci.2021.102649.

Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang Li, Fang B, Poyurovsky M, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature (2021). https://doi.org/10.1038/s41586-021-03539-7.

Lei G, Zhang Y, Hong T, Zhang X, Liu X, Mao C, Yan Y, Koppula P, Cheng W, Sood A, Liu J, Gan B. Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity. Oncogene 2021, https://doi.org/10.1038/s41388-021-01790-w.

Yan Y, Lei G, Gan B. A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular & Cellular Oncology 2021, https://doi.org/10.1080/23723556.2021.1919006.

Lei G, Mao C, Yan Y, Zhuang L, Gan B. Ferroptosis, radiotherapy, and combination therapeutic strategies. Protein Cell. 2021 Apr 23. doi: 10.1007/s13238-021-00841-y. Epub ahead of print. PMID: 33891303.

Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian S, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nature Communications. 12, 1589 (2021). https://doi.org/10.1038/s41467-021-21841-w.

Klionsky D, et al., Gan B, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Feb 8:1-382. doi: 10.1080/15548627.2020.1797280. Epub ahead of print. PMID: 33634751.

Koppula P, Zhuang L, Gan B. Cytochrome P450 reductase (POR) as a ferroptosis fuel. Protein Cell. 2021 Feb 4. doi: 10.1007/s13238-021-00823-0. Epub ahead of print. PMID: 33539003.

Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut. 2021 Jan 24:gutjnl-2020-321175. doi: 10.1136/gutjnl-2020-321175. Epub ahead of print. PMID: 33487592.

2020

Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edge sword in cellular redox regulation. Genes & Diseases. 2020. https://doi.org/10.1016/j.gendis.2020.11.010.

Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401.

Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2020 Oct 1;. doi: 10.1007/s13238-020-00789-5. [Epub ahead of print] Review. PubMed PMID: 33000412.

Zhang Y, Shi J, Liu X, Xiao Z, Lei G, Lee H, Koppula P, Cheng W, Mao C, Zhuang L, Ma L, Li W, Gan B. H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death. Cancer Res. 2020 Jun 1;80(11):2243-2256. doi: 10.1158/0008-5472.CAN-19-3580. Epub 2020 Apr 9. PubMed PMID: 32273282; PubMed Central PMCID: PMC7272265.

Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30. PubMed PMID: 32231310; PubMed Central PMCID: PMC7194135.

Chauhan AS, Zhuang L, Gan B. Spatial control of AMPK signaling at subcellular compartments. Crit Rev Biochem Mol Biol. 2020 Feb;55(1):17-32. doi: 10.1080/10409238.2020.1727840. Epub 2020 Feb 18. PubMed PMID: 32069425.

Hyemin Lee, Li Zhuang, Boyi Gan. Energy stress inhibits ferroptosis via AMPK, Molecular & Cellular Oncology. 2020 June; 7 (4).  DOI: 10.1080/23723556.2020.1761242.

Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B. Energy stress-mediated AMPK activation inhibits ferroptosis. Nature Cell Biology. 22, 225–234 (2020). https://doi.org/10.1038/s41556-020-0461-8.

Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. The Role of Ferroptosis in Ionizing Radiation–Induced Cell Death and Tumor Suppression. Cell Research, 2020; 30 (2), 146-162. PMID: 31949285.

2019

Chauhan AS, Zhuang L, Gan B. Antagonism Between Antiviral Signaling and Glycolysis. Trends Endocrinol Metab, 2019; 30 (9), 571-573.

Gan B. DUBbing Ferroptosis in Cancer Cells. Cancer Res. 2019 Apr 15;79(8):1749-1750. doi: 10.1158/0008-5472.CAN-19-0487

Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle. 2019 Mar 23:1-11. doi: 10.1080/15384101.2019.1597506. [Epub ahead of print]

Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J. 2019 Feb;33(2):2957-2970. doi: 10.1096/fj.201801225R. Epub 2018 Oct 18.

2018

Zhang Y, Zhuang L, Gan B. BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. Molecular & Cellular Oncology, 2018. DOI: 10.1080/23723556.2018.1536845.

Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 Dec;50(12):1705-1715. doi: 10.1038/s41588-018-0252-3. Epub 2018 Oct 22

Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao Z, Jung M, Chen J, Huang P, Gan B. BAP1 links metabolic regulation of ferroptosis to tumor suppression. Nature Cell Biology, 2018 Oct; 20(10):1181-1192. PMCID: PMC6170713.

Yadav RK, Chauhan AS, Zhuang L, Gan B. FoxO transcription factors in cancer metabolism. Semin Cancer Biol. 2018;50:65-76. doi: 10.1016/j.semcancer.2018.01.004 PMID: 29309929

Koppula, P., Zhang, Y., Zhuang, L., Gan B. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (2018) 38: 12. https://doi.org/10.1186/s40880-018-0288-x

2017

Xiao ZD, Han L, Lee H, Zhuang L, Zhang YL, Baddour J, Nagrath D, Wood CG, Gu J, Wu X, Liang H, Gan B. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nature Communications 2017 Oct 4; 8(1):783. doi: 10.1038/s41467-017-00902-z. PMID: 28978906.

Koppula P, Zhang Y, Shi J, Li W, Gan B. The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J. Biol. Chem 292(34):14240-14249, 2017. PMID: 28630042.

Jonasch E, Hasanov E, Corn P, Moss T, Shaw K, Stovall S, Marcott V, Gan B, Bird S, Wang X, Do K, Altamirano P, Zurita A, Doyle L, Lara P, Tannir NM. A Randomized Phase 2 Study of MK-2206 versus Everolimus in Refractory Renal Cell Carcinoma. Ann Oncol 28(4):804-808, 2017. PMID: 28049139.

Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, Xiao Z, You J, Li W, Su X, Gan B. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A 114(12):3192-3197, 2017.

2016

Liu X, Gan B. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle 15(24):3471-3481, 2016. PMID: 27792451.

Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res 76(21):6424-6435, 2016. PMID: 27569213.

Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism. Bioessays 38(10):991-6, 2016. PMID: 27550823.

Xiao ZD, Liu X, Zhuang L, Gan B. NBR2: a former junk gene emerges as a key player in tumor suppression. Molecular & Cellular Oncology 3(4):e1187322, 2016.

Liu X, Xiao ZD, Gan B. An lncRNA switch for AMPK activation. Cell Cycle May 6:1-2(15):1948-9, 2016. PMID: 27152502.

Liu X, Xiao ZX, Han L, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Liang H, Gan B. lncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology 18(4):431-42, 2016.

Lee H, Dai F, Zhuang L, Xiao Z, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget 7(15):19134-19146, 2016.

2015

Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology 17(4):490-9, 2015.

2014

Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, Gan B. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene 33(24):3183-94, 2014. PMID: 23851496.

Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacological inhibition of the PI3K-AKT pathway. Cancer Res 74(6):1682-93, 2014. PMID: 24448243.

2013

Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 110(36):14520-7, 2013. PMID: 23918370.

Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood 121(18):3619-30, 2013. PMID: 23444404.

Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev 27(8):916-27, 2013. PMID: 23630076

2012

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell 149(3):656-70, 2012. PMID: 22541435.

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148(5):896-907, 2012. PMID: 22341455.

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4):651-63, 2012. PMID: 22341440.

Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice. Endocrinology 153(2):631-46, 2012. PMID: 22147007.

2005-2011

Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes and Development 25(14):1510-1527, 2011. PMID: 21764854.

Zhang Y, Gan B, Liu D, Paik JH. FoxO family members in cancer. Cancer Biology and Therapy 12(4):253-259, 2011. PMID: 21613825.

Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 2010. PMID: 21124456.

Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG Jr, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-484, 2010. PMID: 21075312.

Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010. PMID: 20478531.

Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. Journal of Biological Chemistry 285(5):3499-3509, 2010. PMID: 19940130.

Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 8(7):1003-6, 2009. PMID: 19270523.

Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. Journal of Biological Chemistry 284(9):6004-6013, 2009.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 105(49):19384-9, 2008. PMID: 19052232.

Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Molecular and Cellular Biology 28(8):2771-2781, 2008. PMID: 18285457.

Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 20(5):787-94, 2008. PMID: 18036779.

Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. Journal of Biological Chemistry 282(43):31766, 2007. PMID: 17716968.

Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. Journal of Biological Chemistry 281(49):37321-37329, 2006. PMID: 17043358.

Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem 281(24):16664-16671, 2006. PMID: 16617055.

Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175(1):121-133, 2006. PMID: 17015619.

Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res 65(15):6676-6684, 2005. PMID: 16061648.

Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell 9(2):185-196, 2005. PMID: 16054026

Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 170(3):379-389, 2005. PMID: 16043512.