March 11, 2021
Our manuscript "mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation" is published in Nature Commuications.
February 08, 2021
Our collaborative manuscript "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)" is published in Autophagy.
February 04, 2021
Our manuscript "Cytochrome P450 reductase (POR) as a ferroptosis fuel" is published in Protein & Cell.
January 24, 2021
Our collaborative manuscript "Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma" is published in Gut.
January 20, 2021
Congratulations to Yilei for his new independent position at Xi’an Jiaotong University!
January 01, 2020
The Gan lab is featured in the MD Anderson Radiation Oncology Division's Annual Research and Education Newsletter.
December 17, 2020
Our collaborative manuscript "A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia" is published in Molecular Cell.
December 07, 2020
Hyemin Lee received Annual Recognition and Awards from Radiation Division, MD Anderson Cancer Center. Congratulations!
November 18, 2020
Our manuscript "NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edge sword in cellular redox regulation" is published in Genes & Diseases.
October 01, 2020
Our manuscript "Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy" is published in Protein & Cell.
Boyi received 2020 Faculty Honoree Award in Research Excellence from MD Anderson Cancer Center.
Xiaoguang Liu received Jeffrey Lee Cousins Fellowship in Lung Cancer Research from MD Anderson Cancer Center. Congratulations!
July 23, 2020
Pranavi received the 2020 G&E Student Service Award from GSBS. Congratulations!
May 21, 2020
Our manuscript "Energy stress inhibits ferroptosis via AMPK" is published in Molecular and Cellular Oncology.
April 09, 2020
Our manuscript "H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death" is published in Cancer Research.
March 30, 2020
Our manuscript "Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer"" is published in Nature Cell Biology.
Mentions in New and Blogs:
Sciencenewsnet.in - New therapeutic strategies proposed for some lung and kidney cancers
Newswise - New therapeutic strategies proposed for some lung and kidney cancers
MedicalXpress - Study shows cancers with high levels of the SLC7A11 gene may respond to glucose transporter inhibitor treatment
ecancer - New therapeutic strategies proposed for some lung and kidney cancers
gilmermirror - New therapeutic strategies proposed for some lung and kidney cancers
The Medical News - Weakness in lung and kidney cancer cells could serve as therapeutic target
February 18, 2020
Our manuscript "Spatial control of AMPK signaling at subcellular compartments"" is published in Critical Reviews in Biochemistry and Molecular Biology.
Feb 6, 2020
Our manuscript “Energy stress-mediated AMPK activation inhibits ferroptosis” is published in Nature Cell Biology.
Jan 16, 2020
Our manuscript “The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression” is published in Cell Research.
Jan 3, 2020
Our manuscript “Energy stress-mediated AMPK activation inhibits ferroptosis” is accepted by Nature Cell Biology.
November 27, 2019
Our manuscript “The Role of Ferroptosis in Ionizing Radiation–Induced Cell Death and Tumor Suppression” is accepted by Cell Research.
May 2, 2019
Pranavi’s CPRIT Graduate Student Award is renewed. Congratulations!
April 15, 2019
Our manuscript “DUBbing Ferroptosis in Cancer Cells” is published in Cancer Research.
April 5, 2019
Yilei received The Harold C. and Mary L. Daily Endowment Fellowship from MD Anderson Cancer Center. Congratulations!
March 24, 2019
Our manuscript “Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC” is published in Cell Cycle.
Dec. 12, 2018
Pranavi received Steve Lasher and Janiece Longoria Graduate Student Research Award in Cancer Biology from GSBS. Congratulations!
Nov. 13, 2018
Our Author’s Views article “BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression” is published in Molecular & Cellular Oncology.
Oct. 18, 2018
Our manuscript "STIM2 interacts with AMPK and regulates calcium-induced AMPK activation" is published in the FASEB Journal.
Sept. 22, 2018
Pranavi received 2nd place Poster Award at G&E Retreat. Congratulations!
Sept. 10, 2018
Our manuscript "BAP1 links metabolic regulation of ferroptosis to tumour suppression" is published in Nature Cell Biology.
Our research is highlighted in media release:
Aug. 31, 2018
Pranavi received Dr. John J. Kopchick Research Award from GSBS. Congratulations!
Aug. 9, 2018
Boyi received Faculty Scholar Award at MD Anderson Cancer Center.
July 26, 2018
Our manuscript "BAP1 links metabolic regulation of ferroptosis to tumor suppression" is accepted in Nature Cell Biology.
April 25, 2018
Our review article “Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer” is published in Cancer Communications.
April 6, 2018
Pranavi received CPRIT Graduate Student Award. Congratulations!
Jan. 8, 2018
Our review article “FoxO transcription factors in cancer metabolism” is published in Seminars in Cancer Biology.
Oct. 4, 2017
Our study “Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development” is published in Nature Communications.
Sept. 21, 2017
Boyi talked about his research to fight cancer in the Research Spotlight of the Center for Energy Balance at MD Anderson newsletter.
Sept. 18, 2017
Pranavi Koppula, a 2nd year graduate student from GSBS, was selected as the Center of Cancer Epigenetics (CCE) Scholar at MD Anderson. Congratulation! Pravani recently published a first-author paper from our lab which discovered that glutamate/cystine antiporter SLC7A11/xCT regulates nutrient dependency in cancer cells.
June 19, 2017
Our publication “The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate” is published in J. Biol. Chem.
June 1, 2017
Boyi is promoted to Associate Professor at MD Anderson.
May 8, 2017
Boyi was selected as the Andrew Sabin Family Fellow at MD Anderson Cancer Center.
March 8, 2017
Our study “BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response” is published in Proc Natl Acad Sci U S A.
Dec. 16, 2016
Our study “lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1” is published in Cell Cycle.
Nov. 29, 2016
Boyi received Anna Fuller Award to support our research in long non-coding RNA in cancer metabolism.
Aug. 1, 2016
Read our reviews to discuss long non-coding RNAs in cancer metabolism.
May 2, 2016
Yilei Zhang, a postdoctoral fellow from our lab, was selected as the Center of Cancer Epigenetics (CCE) Scholar at MD Anderson. Congratulation!
April 13, 2016
Our research is highlighted in Cancer Frontline.
April 12, 2016
Our study “BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21” was published in Oncotarget.
March 31, 2016
Our research is highlighted by Department of Defense-Congressionally Directed Medical Research Programs.
March 21, 2016
Our manuscript “lncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress” is published in Nature Cell Biology.