News & Media
2023
May 15, 2023
Our collaborative manuscript "Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells" is published in Cancer Research.
May 10, 2023
Our review article "Ferroptosis vulnerability in FLT3-mutant leukemia" is published in Trends in Cancer.
May 1, 2023
Boyi received the N.G. and Helen T. Hawkins Distinguished Professorship for Cancer Research.
March 17, 2023
Our commentary "Ferroptosis hijacking by Mycobacterium tuberculosis" is published in Nature Communications.
March 16, 2023
Our commentary "How erastin assassinates cells by ferroptosis revealed" is published in Protein & Cell.
February 6, 2023
Our manuscript "Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis" is published in Nature Cell Biology.
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Mentions in News and Blogs:
- Nature - Cell death discovery adds fresh angle to attack cancer
- MD Anderson Newsroom - New cell death mechanism could offer novel cancer treatment strategies
- ScienMag - New cell death mechanism could offer novel cancer treatment strategies
- Newswise - New cell death mechanism could offer novel cancer treatment strategies
- Sciencenewsnet.in - New cell death mechanism could offer novel cancer treatment strategies
- Psychreg - New Cell Death Mechanism Could Offer Novel Cancer Treatment Strategies
- The Medical News - Study reveals mechanism of a previously unexplained type of cell death
- Nouvelles du monde - Une étude révèle le mécanisme d’un type de mort cellulaire jusque-là inexpliqué
- Latestly - Study Finds New Cell Death Mechanism Helps to Treat Cancer
- Devdiscourse - Study finds new cell death mechanism helps to treat cancer
- news-medical.net - Study reveals mechanism of a previously unexplained type of cell death
- Science Blog - New Way That Cells Die Opens Door To Cancer Treatments
2022
December 2, 2022
Congratulations to Chao for being selected as a 2022 STAT Wunderkind, an award that recognizes the work of early-career scientists and clinicians.
Our commentary article "A Time and Place for Inhibiting Autophagy" is published in Cancer Research.
October 27, 2022
Our collaborative manuscript "USP7 substrates identified by proteomics analysis reveal the specificity of USP7" is published in Genes & Development.
September 15, 2022
Our preview article "Ferroptosis execution: Is it all about ACSL4?" is published in Cell Chemical Biology.
August 8, 2022
Our commentary article "Navigating ferroptosis via an NADPH sensor" is published in Nature Cell Biology.
July 31, 2022
Our commentary article "Ferroptosis vulnerability in MYCN-driven neuroblastomas" is published in Clinical and Translational Medicine.
June 25, 2022
Our article "Assessment of lipid peroxidation in irradiated cells" is published in Methods in Cell Biology.
June 24, 2022
Our manuscript "A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria" is published in Proceedings of the National Academy of Sciences.
June 8, 2022
Our commentary article "PKCβII–ACSL4 pathway mediating ferroptosis execution and anti-tumor immunity" is published in Cancer Communications.
April 22, 2022
Our commentary article "ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity" is published in Signal Transduction and Targeted Therapy.
April 22, 2022
Our manuscript "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" is published in Nature Communications.
March 31, 2022
Congratulations to Chao for receiving the Harter Prize from MD Anderson Cancer Center and for winning the Oral Competition Award on trainee research day!
March 25, 2022
Our review article "Targeting ferroptosis as a vulnerability in cancer" is published in Nature Reviews Cancer.
March 9, 2022
Our review article "Iron out KRAS-driven cancer" is published in Journal of Experimental Medicine.
January 27, 2022
Congratulations to Chao for receiving the 2022 Outstanding Research Publication Award from MD Anderson!
January 5, 2022
Congratulations to Chao! His Nature article is selected to be highlighted in the Wall of Science at MD Anderson.
2021
December 17, 2021
Our collaborative manuscript "A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis" is published in Nature Communications.
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December 8, 2021
Our manuscript "Thiol profiling in cancer cell lines by HPLC-mass spectrometry" is published in Star Protocols.
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November 26, 2021
Our manuscript "Ferroptosis as an important driver of lupus" is published in Protein & Cell.
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November 11, 2021
Our publication "Ferroptosis, radiotherapy, and combination therapeutic strategies" is selected as the cover image in the November 2021 issue of Protein & Cell.
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November 6, 2021
The Gan lab participated in the annual Boot Walk to End Cancer!
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October 17, 2021
Our manuscript "Phospholipase iPLA2β acts as a guardian against ferroptosis" is published in Cancer Communications.
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September 2, 2021
Congratulations to Pranavi on the successful defense of her thesis titled “Investigating therapeutic strategies to target metabolic vulnerabilities of NSCLC tumors with mutant KEAP1 Gene”!
See lab photo
September 1, 2021
Boyi is promoted to Professor at MD Anderson Cancer Center.
August 27, 2021
Boyi Received The Dallas/Fort Worth Living Legend Faculty Achievement Award in Basic Research.
August 23, 2021
Our research is highlighted in the homepage of GSBS Genetics & Epigenetics (G&E) Program.
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July 30, 2021
Our review article "Mitochondrial regulation of ferroptosis" is published in Journal of Cell Biology.
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June 14, 2021
Our manuscript "mTORC1 and ferroptosis: regulatory mechanisms and therapeutic potential" is published in BioEssays.
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June 1, 2021
Our manuscript “Ether phospholipids govern ferroptosis” is published in Journal of Genetics and Genomics.
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May 25, 2021
Our manuscript “KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition” is published in iScience.
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May 13, 2021
Congratulations to Xiaoguang! His Nature Cell Biology article is selected to be highlighted in the Wall of Science at MD Anderson.
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May 12, 2021
Our manuscript “DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer” is published in Nature.
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Mentions in News and Blogs:
- MD Anderson News Release - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- Nature - A mitochondrial gatekeeper that helps cells escape death by ferroptosis
- GEN News - Novel Cancer Therapeutic Target Found in Mitochondrial Enzyme
- Mirage News - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- MedicalXpress - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- EurekAlert! - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- ScienMag - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- Bioengineer.org - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- Infosurhoy - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- ecancer - Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
- Ebiotrade - 甘波谊Nature发文：线粒体酶可以阻断细胞死亡途径，为新的癌症治疗指明了方向
- Science 2.0 Blogs - Mitochondrial Enzyme DHODH, Ferroptosis, And Maybe A New Cancer Treatment Strategy
- Signal Transduction and Targeted Therapy - DHODH tangoing with GPX4 on the ferroptotic stage
April 30, 2021
Xiaoguang Liu and Chao Mao received Jeffrey Lee Cousins Fellowship in Lung Cancer Research from MD Anderson Cancer Center. Congratulations!
April 29, 2021
Our manuscript "Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity" is published in Oncogene.
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April 27, 2021
Our manuscript "A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis" is published in Molecular & Cellular Oncology.
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April 23, 2021
Our review article "Ferroptosis, radiotherapy, and combination therapeutic strategies" is published in Protein & Cell.
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March 11, 2021
Our manuscript "mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation" is published in Nature Communications.
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February 08, 2021
Our collaborative manuscript "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)" is published in Autophagy.
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February 04, 2021
Our manuscript "Cytochrome P450 reductase (POR) as a ferroptosis fuel" is published in Protein & Cell.
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January 24, 2021
Our collaborative manuscript "Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma" is published in Gut.
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January 20, 2021
Congratulations to Yilei for his new independent position at Xi’an Jiaotong University!
January 01, 2021
The Gan lab is featured in the MD Anderson Radiation Oncology Division's Annual Research and Education Newsletter.
Read the article, page 7
2020
December 17, 2020
Our collaborative manuscript "A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia" is published in Molecular Cell.
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December 07, 2020
Hyemin Lee received Annual Recognition and Awards from Radiation Division, MD Anderson Cancer Center. Congratulations!
November 18, 2020
Our manuscript "NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edge sword in cellular redox regulation" is published in Genes & Diseases.
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October 01, 2020
Our manuscript "Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy" is published in Protein & Cell.
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August 21, 2020
Boyi received 2020 Faculty Honoree Award in Research Excellence from MD Anderson Cancer Center.
August 2020
Xiaoguang Liu received Jeffrey Lee Cousins Fellowship in Lung Cancer Research from MD Anderson Cancer Center. Congratulations!
July 23, 2020
Pranavi received the 2020 G&E Student Service Award from GSBS. Congratulations!
May 21, 2020
Our manuscript "Energy stress inhibits ferroptosis via AMPK" is published in Molecular and Cellular Oncology.
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April 09, 2020
Our manuscript "H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death" is published in Cancer Research.
March 30, 2020
Our manuscript "Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer"" is published in Nature Cell Biology.
Mentions in News and Blogs:
Sciencenewsnet.in - New therapeutic strategies proposed for some lung and kidney cancers
Newswise - New therapeutic strategies proposed for some lung and kidney cancers
MedicalXpress - Study shows cancers with high levels of the SLC7A11 gene may respond to glucose transporter inhibitor treatment
ecancer - New therapeutic strategies proposed for some lung and kidney cancers
gilmermirror - New therapeutic strategies proposed for some lung and kidney cancers
The Medical News - Weakness in lung and kidney cancer cells could serve as therapeutic target
February 18, 2020
Our manuscript "Spatial control of AMPK signaling at subcellular compartments"" is published in Critical Reviews in Biochemistry and Molecular Biology.
Feb 6, 2020
Our manuscript “Energy stress-mediated AMPK activation inhibits ferroptosis” is published in Nature Cell Biology.
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Jan 16, 2020
Our manuscript “The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression” is published in Cell Research.
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Jan 3, 2020
Our manuscript “Energy stress-mediated AMPK activation inhibits ferroptosis” is accepted by Nature Cell Biology.
2019
November 27, 2019
Our manuscript “The Role of Ferroptosis in Ionizing Radiation–Induced Cell Death and Tumor Suppression” is accepted by Cell Research.
May 2, 2019
Pranavi’s CPRIT Graduate Student Award is renewed. Congratulations!
April 15, 2019
Our manuscript “DUBbing Ferroptosis in Cancer Cells” is published in Cancer Research.
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April 5, 2019
Yilei received The Harold C. and Mary L. Daily Endowment Fellowship from MD Anderson Cancer Center. Congratulations!
March 24, 2019
Our manuscript “Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC” is published in Cell Cycle.
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2018
Dec. 12, 2018
Pranavi received Steve Lasher and Janiece Longoria Graduate Student Research Award in Cancer Biology from GSBS. Congratulations!
Nov. 13, 2018
Our Author’s Views article “BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression” is published in Molecular & Cellular Oncology.
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Oct. 18, 2018
Our manuscript "STIM2 interacts with AMPK and regulates calcium-induced AMPK activation" is published in the FASEB Journal.
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Sept. 22, 2018
Pranavi received 2nd place Poster Award at G&E Retreat. Congratulations!
Sept. 10, 2018
Our manuscript "BAP1 links metabolic regulation of ferroptosis to tumour suppression" is published in Nature Cell Biology.
Read accompanying preview
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Our research is highlighted in media release:
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Aug. 31, 2018
Pranavi received Dr. John J. Kopchick Research Award from GSBS. Congratulations!
Aug. 9, 2018
Boyi received Faculty Scholar Award at MD Anderson Cancer Center.
July 26, 2018
Our manuscript "BAP1 links metabolic regulation of ferroptosis to tumor suppression" is accepted in Nature Cell Biology.
April 25, 2018
Our review article “Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer” is published in Cancer Communications.
April 6, 2018
Pranavi received CPRIT Graduate Student Award. Congratulations!
Jan. 8, 2018
Our review article “FoxO transcription factors in cancer metabolism” is published in Seminars in Cancer Biology.
2017
Oct. 4, 2017
Our study “Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development” is published in Nature Communications.
Sept. 21, 2017
Boyi talked about his research to fight cancer in the Research Spotlight of the Center for Energy Balance at MD Anderson newsletter.
Sept. 18, 2017
Pranavi Koppula, a 2nd year graduate student from GSBS, was selected as the Center of Cancer Epigenetics (CCE) Scholar at MD Anderson. Congratulation! Pravani recently published a first-author paper from our lab which discovered that glutamate/cystine antiporter SLC7A11/xCT regulates nutrient dependency in cancer cells.
June 19, 2017
Our publication “The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate” is published in J. Biol. Chem.
June 1, 2017
Boyi is promoted to Associate Professor at MD Anderson.
May 8, 2017
Boyi was selected as the Andrew Sabin Family Fellow at MD Anderson Cancer Center.
March 8, 2017
Our study “BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response” is published in Proc Natl Acad Sci U S A.
2016
Dec. 16, 2016
Our study “lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1” is published in Cell Cycle.
Nov. 29, 2016
Boyi received Anna Fuller Award to support our research in long non-coding RNA in cancer metabolism.
Aug. 1, 2016
Read our reviews to discuss long non-coding RNAs in cancer metabolism.
Long non-coding RNAs in cancer metabolism
An lncRNA switch for AMPK activation
NBR2: A former junk gene emerges as key player in tumor suppression
May 2, 2016
Yilei Zhang, a postdoctoral fellow from our lab, was selected as the Center of Cancer Epigenetics (CCE) Scholar at MD Anderson. Congratulation!
April 13, 2016
Our research is highlighted in Cancer Frontline.
April 12, 2016
Our study “BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21” was published in Oncotarget.
March 31, 2016
Our research is highlighted by Department of Defense-Congressionally Directed Medical Research Programs.
March 21, 2016
Our manuscript “lncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress” is published in Nature Cell Biology.