Welcome to the Gan Laboratory at MD Anderson Cancer Center. Our research focuses on the roles of energy metabolism and nutrient sensing in cancer. We study how normal cells and cancer cells sense energy and nutrient availability and how cancer cells adapt to survive and grow under metabolic stress. Our work aims to translate our understanding of cancer metabolism into novel effective cancer therapeutics.
The Gan Laboratory is studying energy metabolism and nutrient sensing in cancer by answering the following questions:
- How do normal cells and cancer cells sense energy and nutrient availability?
- Hwo do canc cells adapt to survive and grow under metabolic stress?
- How can we translate our understanding of energy metabolism in cancer cells into novel cancer therapeutics
Our research projects include:
- The roles of energy sensors AMPK and FoxO, as well as their associated long non-coding RNAs (lncRNAs) in energy sensing and tumor metabolism
- The crosstalk between cancer metabolism and epigenetics
- The role of glutamate/cystine antiporter SLC7A11 in the regulation of nutrient dependency and cancer metabolism
Our research approach
The Gan Laboratory uses functional studies, such as mouse models, to enhance our understanding of the molecular mechanisms that govern the cellular pathways of cancer metabolism. Our goal is to then translate our research discoveries into the clinic through novel therapeutics targeting critical steps in these cancer metabolism pathways.