Goal: To elucidate the mechanisms that regulate cell turnover while preserving barrier function in epithelia and identify specific alterations that go awry during pathogenesis.
How we do it: Use the powerful cellular and genetic tools available in the developing zebrafish to dissect cell turnover in a living epithelial tissue.
Meet the team
From left to right: George Eisenhoffer, Oscar Ruiz, Stephen Wallin, Courtney Brock and Jovany Franco
Oscar Ruiz, Ph.D., receives first place in the 2016 Nikon Small World Photo Competition
Ruiz brings the world face-to-face with his research on facial development and cellular morphogenesis with his winning image of a four-day-old zebrafish embryo. Ruiz uses the zebrafish to study genetic mutations that lead to facial abnormalities such as cleft lip and palate in humans in the lab of George Eisenhoffer, Ph.D.. Click here to read more and see this award winning photo.
Eisenhoffer GT, Slattum G, Ruiz OE, Otsuna H, Bryan CD, Lopez J, Wagner DS, Bonkowsky JL, Chien CB, Dorsky RI, Rosenblatt J. A toolbox to study epidermal cell types in zebrafish. J Cell Sci.(2016) pii: jcs.184341. PubMed PMID: 27149923.
Eisenhoffer GT, Rosenblatt J. Bringing balance by force: live cell extrusion controls epithelial cell numbers. Trends Cell Biol 23(4):185-92, (2013) PMCID: PMC3615095
Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature 484(7395):546-9, (2012) PMCID: PMC4593481