Research projects in the Cascone Laboratory are focused on the following major areas:
- Uncover the T and B cell-mediated mechanisms that contribute to tumor response and resistance to immune-based therapies for operable non-small cell lung cancer (NSCLC). We use subcutaneous murine models of spontaneously metastatic NSCLC expressing T and B cell antigens and patient samples from unique neoadjuvant immunotherapy trials for this work.
- Derive optimal perioperative therapeutic strategies to augment the efficacy of immune checkpoint blockade via maturation and enhanced function of tertiary lymphoid structure (TLS) in non-small cell lung cancer. We use subcutaneous and orthotopic murine models of spontaneously metastatic NSCLC expressing a B cell antigen and patient samples from unique neoadjuvant immunotherapy trials for this work.
- Determine the efficacy and immune-modulatory mechanisms of next-generation CTLA-4 inhibitors for the neo-adjuvant treatment of murine models of NSCLC expressing a tumor-specific T cell antigen.