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Patients who receive a shorter course of whole breast radiation therapy for early-stage disease experience less toxicity and improved quality of life compared with those who undergo longer treatment, MD Anderson researchers report in JAMA Oncology.
"Randomized studies in the United Kingdom and Canada have shown equal rates of recurrence in both groups, as well as equal survival," says Simona Shaitelman, M.D., assistant professor, Radiation Oncology, and the study's first author. "With modern technology, and knowing that the survival and recurrence outcomes are equal, can we offer patients a better option?"
For the study, patients were enrolled at MD Anderson, the institution's Houston-area locations, Orlando Health (Formerly MD Anderson Orlando) in Orlando, Fla., and Banner MD Anderson in Gilbert, Ariz.
The study was funded by the Conquer Cancer Foundation of the American Society of Clinical Oncology, the Breast Cancer Research Foundation, the Cancer Prevention and Research Institute of Texas, MD Anderson's Center for Radiation Oncology Research, a philanthropic gift from Ann and Clarence Cazalot and the National Cancer Institute.