Colorectal cancer may quietly damage nerves prior to chemotherapy
Researchers at The University of Texas MD Anderson Cancer Center found that, in preclinical models of colorectal cancer, tumors can start damaging peripheral nerves before chemotherapy begins. These findings suggest tumor-related inflammation and changes to fat metabolism could damage the protective coating around nerves, disrupting signals and potentially making them more vulnerable to treatment-induced peripheral neuropathy, or nerve...
Hodgkin lymphoma survivors face twice the risk of death compared to average American adult
Adults who survive Hodgkin lymphoma (HL) for at least five years face increased risk of death from non-cancer conditions and cardiovascular...
Biomarkers may help identify lung cancer patients who benefit most from perioperative immunotherapy
Phase 3 CheckMate 77T trial demonstrated improved outcomes from immunotherapy given before and after surgery, called perioperative immunotherapy...
Scientists uncover drivers of recurrent arthritis after immunotherapy, suggesting potential biomarkers
Some patients receiving immunotherapy can develop recurrent inflammatory arthritis that often worsens in subsequent flare-ups
Researchers identified immune cells that were present during both the initial and recurrent arthritis flares
Findings suggest that recurrent inflammatory arthritis behaves like an immune-memory disease, with the same immune cell populations expanding and becoming more aggressive over time</...
Immune cell dysfunction, not absence, defines skin cancer in immunosuppressed patients
Patients with weakened immune systems develop non-melanoma skin cancers that are more frequent, more aggressive, and more often lethal ...