Immune cells use previously unknown pathway to eliminate AML
Researchers identified a previously unknown way in which T cells can attack acute myeloid leukemia (AML) cells, even when the AML cells evade conventional immune recognition
The process does not require the usual markers that normally guide T cells to cancer cells, surprising scientists
These findings may explain AML’s sensitivity to immune-based therapies and could inform future therapeutic strategies
Researchers at The University...
Immune ecotypes may explain multiple myeloma outcomes missed by disease staging
Researchers mapped immune cells and their interactions across multiple myeloma and its precursor conditions
The study identified five tumor...
Novel CAR T cell therapy offers promising option for hard-to-treat kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, and patients who progress on standard therapies have limited...
Epigenetic therapy shows promise against treatment-resistant AML
Next-generation epigenetic therapy showed stronger anti-leukemia activity than current standard treatments in preclinical models of acute myeloid leukemia (AML)
The drug remained effective in treatment-resistant leukemias and enhanced responses when combined with venetoclax, a standard frontline treatment
Researchers identified activation of the Hippo pathway, a natural regulator of cell growth, as a previously unrecognized...
KRAS-targeting drugs show promise for rare appendix cancer
KRAS is the most common genetic mutation in appendix cancer, occurring in approximately 80% of mucinous tumors, the most common subtype
KRAS-targeted...
Experimental cell therapy delivers encouraging results for patients with rare, potentially fatal brain infection
No approved treatments exist for progressive multifocal leukoencephalopathy (PML), a serious neurological condition caused by the JC virus...
Fasting primes gut microbiome to improve intestinal recovery after radiation treatment
Researchers identified a gut bacterium that helps prime intestinal stem cells for faster recovery
In preclinical models, short-term...
Microscopic colorectal cancer liver metastases harbor features that enable cancer cells to survive treatment and drive disease recurrence
Researchers...
Scientists develop new, improved method to find and isolate the strongest cancer-fighting immune cells
Isolating immune cells that can best identify and attack cancer cells is challenging because these cells are rare within tumors
Researchers...
Novel antibody-drug conjugate eliminates residual cancer cells in majority of patients with B-cell ALL
Seventy percent of patients had residual levels of cancer cells eliminated
Clearing residual cancer cells is a strong predictor...
Scientists uncover why some patients with rare leukemia may not benefit from approved targeted therapy
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive form of acute leukemia
Tagraxofusp is the first approved therapy...
New study identifies genetic markers that could guide emerging prostate cancer treatments
Ferroptosis is a type of cell death that has emerged as a promising avenue to target cancers that are resistant to current therapies
This study...
Biomarker-guided drug combinations may improve outcomes in treatment-resistant melanoma
In a preclinical study, adding a BCL2 inhibitor to standard melanoma therapy shrank tumors that had stopped responding to therapy
The study...