Services
Fees for service are currently under institutional review, but will be posted as soon as they are available.
EVcore provides routine services for extracellular vesicle isolation, purification, molecular characterization, molecular analysis, content detection and subtype sorting. EVcore supports large-scale EV engineering and production, with fees varying by project need and available upon request. Our staff are also available to assist users with experimental design and downstream computational support on an hourly basis. Kindly note that EVcore does not offer user access to the instrumentation.
An initial consultation call will be scheduled with new users, free of charge, to ensure that we can best serve the needs of your project. New users should complete the EVcore Project Intake Form, and our team will contact you to schedule the online consultation. All services requests may then be placed and managed through iLab (coming soon!).
If new services are needed, or we may be able to support your project through a service not listed, please contact us.
EVcore Fee Structure
The Extracellular Vesicles and Exosomes Core Facility (EVcore) gratefully acknowledges funding from the Cancer Prevention and Research Institute of Texas (CPRIT) Grant #RP250533. EVcore provides support for cancer and non-cancer related projects across academia and industry, as capacity permits. Investigators seeking support for cancer-related projects will receive prorated fees and service priority, consistent with the purpose and objectives of CPRIT.
Isolation and Purification
Fees per sample of biospecimen or cell culture supernatant, varies by starting volume (up to 150 mL / 151–300 mL / 301-–1000 mL)
| Service | Unit |
|---|---|
| Ultracentrifugation | Sample |
| Density Gradient Ultracentrifugation | Sample |
| Liquid Chromatography, Size Exclusion | Sample |
| Liquid Chromatography, Size Exclusion Fast Performance | Sample |
| Liquid Chromatography, High Performance | Sample |
Molecular Characterization
Fees per sample of biospecimen or cell culture supernatant
| Service | Unit |
|---|---|
| Western Blot | Gel |
| ELISA | Plate |
| Immunoprecipitate Pull-Down | Sample |
Molecular Analysis, Content Detection, Subtype Sorting
Fees per sample of biospecimen or cell culture supernatant
| Service | Unit |
|---|---|
| Fluorescence Activated EV analysis with beads (BD Fortessa) |
Sample |
| Fluorescence Activated EV Detection (Nano FCM) | Sample |
| Fluorescence Activated EV Detection (Cytek) | Sample |
| Fluorescence Activated EV Sorting (Cytek) | Sample |
Specialized Characterization
Fees per sample of biospecimen or cell culture supernatant
| Service | Unit |
|---|---|
| BCA Protein Estimation |
Sample |
| Nanoparticle Tracking Analysis | Sample |
| Nano Imaging | Sample |
| Transmission Electron Microscopy | Sample |
| Cryogenic Electron Microscopy | Sample |
Content Analysis
Content analysis will be outsourced to existing MD Anderson Core Resources. Estimated delivery times are subject to each core facility's availability. Standard fees will be assessed.
| Service | Unit |
|---|---|
| Proteomics Analysis |
Sample |
| Genomics Analysis | Sample |
| Lipidomics Analysis | Sample |
| Epigenomics Analysis | Sample |
Pass-through Supplies
Sourcing and procurement of reagents and supplies not otherwise provided by EVcore or supplied by the user.
| Service | Unit |
|---|---|
| Pass-Through Reagents and Supplies | N/A |
Computational and Bioinformatics Support
Downstream analyses performed by Ph.D. computational biologist with bioinformatics and biostatistics expertise
| Service | Unit |
|---|---|
| Computational analyses | Hour |
EV Production and Engineering
User delivery of cells to the core facility for production and/or engineering of extracellular vesicles. Users are advised to contact EVcore to discuss project specifics and to obtain a quote.
| Service | Unit | Academic User Fees | Non-academic User Fees | Est. Delivery |
|---|---|---|---|---|
| EV Production and Characterization | Run |
Custom project quote | Custom project quote | Varies |
| Large Scale Bio-Reactor Based EV Production and Characterization for Pre-Clinical Studies (GMP-like) | Run |
Custom project quote |
Custom project quote | Varies |
Project Consultation
Initial consultation with core director and/or senior staff designed to understand project's goals, experimental design and support needs. The project consultation is a necessary prerequisite to EVcore utilization and will enable staff to define the scope of services and establish clear expectations for deliverables, timeline and cost. Request a consultation using the Project Intake Form, and EVcore staff will contact prospective users to arrange the consultation.
| Service | Unit | Academic User Fees | Non-academic User Fees | Est. Delivery |
|---|---|---|---|---|
| Initial Consultation Call |
Hour |
Free | Free | - |
| Other Technical Assistance |
Hour |
TBD |
TBD | - |