About
The EVcore is a first-of-its-kind resource in the state of Texas, funded by the Cancer Prevention and Research Institute of Texas (CPRIT), to advance extracellular vesicles-related research and translational medicine. EVcore provides support for extracellular vesicles and exosomes research and clinical translation, spanning fundamental biology studies to engineering and manufacturing.
Extracellular vesicles (EVs) from cerebrospinal fluid (CSF), saliva, tissue, milk, blood, lymph, bile, urine or cell culture supernatant are isolated and purified using SE-FPLC and other technologies. The EVs can be analyzed in several ways, including nanoparticle tracking analysis, single EV analysis and sorting, Western blotting and microscopy. EV engineering for preclinical studies is also provided. First, cells are grown in bioreactors, then pooled, centrifuged and re-suspended. EVs are extracted, and payload can be loaded. They are then prepared for administration in preclinical settings.