Zhao Laboratory
Di Zhao, Ph.D.
Principal Investigator
Areas of Research
- Prostate Cancer Research
- Targeted Therapy Research
Dr. Zhao’s laboratory in the Experimental Radiation Oncology (ERO) department is interested in the functional genomics of prostate cancers with two primarily directions towards (1) understanding how oncogenic signaling pathways and tumor microenvironment regulate cancer development and metastasis, and (2) searching for biomarkers and context-specific therapeutic targets for personalized cancer medicine.
Recent Publications
Wang G#, Zhao D#, Spring DJ, DePinho RA. Genetics and Biology of Prostate Cancer. Genes & Dev. 2018 Sep 1;32(17-18):1105-1140
Zhao D, DePinho RA. Synthetic Essentiality: Targeting tumor suppressor deficiencies in cancer. BioEssays. 2017 Aug;39(8). Review.
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, Spring DJ, Navone NM, Troncoso P, Zhang J, Wang YA, DePinho RA. Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN-deficient cancer. Nature. 2017; 542(7642): 484-488.
Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan KL, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin. Invest. 2014; 124(12): 5453-5465.
Zhao D#, Zou SW#, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013; 23(4): 464-476.
Lab location:
Zayed Building Z7.4018
6565 MD Anderson Blvd Unit
1052
Houston, TX 77030
Contact Dr. Zhao:
P: 713-792-7328 | Office: Z7.3028
Email: Dzhao2@mdanderson.org