Di Zhao, Ph.D.
Areas of Research
- Prostate Cancer Research
- Targeted Therapy Research
Dr. Zhao’s laboratory in the Experimental Radiation Oncology (ERO) department is interested in the functional genomics of prostate cancers with two primarily directions towards (1) understanding how oncogenic signaling pathways and tumor microenvironment regulate cancer development and metastasis, and (2) searching for biomarkers and context-specific therapeutic targets for personalized cancer medicine.
Wang G#, Zhao D#, Spring DJ, DePinho RA. Genetics and Biology of Prostate Cancer. Genes & Dev. 2018 Sep 1;32(17-18):1105-1140
Zhao D, DePinho RA. Synthetic Essentiality: Targeting tumor suppressor deficiencies in cancer. BioEssays. 2017 Aug;39(8). Review.
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, Spring DJ, Navone NM, Troncoso P, Zhang J, Wang YA, DePinho RA. Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN-deficient cancer. Nature. 2017; 542(7642): 484-488.
Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan KL, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin. Invest. 2014; 124(12): 5453-5465.
Zhao D#, Zou SW#, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013; 23(4): 464-476.
NIH/NCI Pathway to Independence Award (K99/R00)
CPRIT Recruitment of First-Time Tenure-Track Faculty
Prostate Cancer Foundation Young Investigator Award