Selected Publications

Selected Peer-Reviewed Publications as of September 2026

1. Zhang J, Park MD, Pandya T, Shum E, Wu J, Heeke S, Salehi-Rad R, Marron TU, Wei Z, Li H, Blum TG, Heymach JV, Dubinett SM, Yang PC, Swanton C, Merad M. Innovative approaches for lung cancer screening and interception. Nat Rev Clin Oncol. 2026;23(5):374-389. doi: 10.1038/s41571-026-01131-4.

2. Zhu B, Aminu M, Chen P, Li JR, Dong C, Li C, Tian Y, Lu SW, Chen H, Ma C, Hu X, Ye J, Liu AY, Huang B, Rojas FR, Parra Cuentas ER, Shi O, Nilsson MB, Poteete A, Khan KB, Lu W, Solis Soto LM, Fujimoto J, Haymaker C, Wistuba II, Wei Z, Wang L, Gibbons DL, Chen K, Reuben A, Schenkel JM, Heymach JV, Cheng C, Wu J, Zhang J. Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure. Adv Sci (Weinh). 2026;13(17):e12597. doi: 10.1002/advs.202512597.

3. Pandya T, Zagorulya M, Leung MM, Augustine M, Liu LY, Leppa AM, Baruchel U, Ng SW, Klockner T, Mugabo M, Griffen AJ, Blyuss O, Iliakis CS, Grenov A, Haase K, Muller DC, Chan KH, Wu J, Burk VA, Wright N, Le Marois A, Pazukhina E, Ward S, Slawinski H, Pelletier M, Murphy C, Park MD, Snoeks T, Suarez-Bonnet A, Priestnall SL, Chardas A, Grieco C, Archer A, Celik A, Jimenez-Sanchez A, Scott R, Zahed H, Montegut L, Meza R, Durney CH, Lam S, Karasaki T, Vermeulen RCH, Xu H, Serrano-Fernandez P, Crnogorac-Jurcevic T, Menon U, Apostolidou S, Zaikin A, Gunu R, Whitwell HJ, Huang Z, Li Z, Hu X, Zhu B, Li L, Chirlaque MD, Guevara M, Kolijn PM, Guenoun A, Mookherjee N, Johansson M, Wang Z, Chatterjee N, Chiu CH, Chen Z, Pe'er D, Sahai E, Freytag S, Wack A, Gunter MJ, Merad M, Zhang J, Carlsten C, Yang PC, Chen HY, Platz EA, LaFave LM, Smith-Byrne K, Jamal-Hanjani M, Litchfield K, Nene NR, McGranahan N, Gronroos E, Hill W, Weeden CE, Swanton C. Plasma signals of lung tumor promotion for molecular cancer prevention. Cell. 2026;189(13):3903-3921.e26. doi: 10.1016/j.cell.2026.05.005.

4. Zhu B, Chen P, Aminu M, Li JR, Fujimoto J, Tian Y, Hong L, Chen H, Hu X, Li C, Vokes N, Moreira AL, Gibbons DL, Solis Soto LM, Parra Cuentas ER, Shi O, Diao S, Ye J, Rojas FR, Vilar E, Maitra A, Chen K, Navin N, Nilsson M, Huang B, Heeke S, Zhang JH, Haymaker CL, Velcheti V, Sterman DH, Kochat V, Padron WI, Alexandrov LB, Wei Z, Le X, Wang L, Fukuoka J, Lee JJ, Wistuba II, Pass HI, Davis M, Hanash S, Cheng C, Dubinett S, Spira A, Rai K, Lippman SM, Futreal PA, Heymach JV, Reuben A, Wu J, Zhang J. Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception. Cancer Cell. 2025;43(6):1125-1140.e10. doi: 10.1016/j.ccell.2025.04.003.

5. Aminu M, Zhu B, Vokes N, Chen H, Hong L, Li J, Fujimoto J, Chaib M, Yang Y, Wang B, Poteete A, Nilsson MB, Le X, Cascone T, Jaffray D, Navin N, Wang T, Byers LA, Gibbons DL, Heymach J, Chen K, Cheng C, Zhang J, Wu J. CoCo-ST detects global and local biological structures in spatial transcriptomics datasets. Nat Cell Biol. 2025;27:2019-2031. doi: 10.1038/s41556-025-01781-z.

6. Saad MB, Al-Tashi Q, Hong L, Verma V, Li W, Boiarsky D, Li S, Petranovic M, Wu CC, Carter BW, Shroff GS, Cascone T, Le X, Elamin YY, Altan M, Heeke S, Sheshadri A, Chang JY, Lee PP, Liao Z, Gibbons DL, Vaporciyan AA, Lee JJ, Wistuba II, Haymaker C, Mirjalili S, Jaffray D, Gainor JF, Lou Y, Di Federico A, Pecci F, Awad M, Ricciuti B, Heymach JV, Vokes NI, Zhang J, Wu J. Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC. Nat Commun. 2025;16:6828. doi: 10.1038/s41467-025-61823-w.

7. Li H, Salehjahromi M, Godoy MCB, Qin K, Plummer CM, Zhang Z, Hong L, Heeke S, Le X, Vokes N, Zhang B, Araujo HA, Altan M, Wu CC, Antonoff MB, Ostrin EJ, Gibbons DL, Heymach JV, Lee JJ, Gerber DE, Wu J, Zhang J. Lung Cancer Risk Prediction in Patients with Persistent Pulmonary Nodules Using the Brock Model and Sybil Model. Cancers (Basel). 2025;17(9):1499. doi: 10.3390/cancers17091499.

8. Grippin AJ, Marconi C, Copling S, Li N, Braun C, Woody C, Young E, Gupta P, Wang M, Wu A, Jeong SD, Soni D, Weidert F, Xie C, Goldenberg E, Kim A, Zhao C, DeVries A, Castillo P, Lohray R, Rooney MK, Schrank BR, Wang Y, Ma Y, Chang E, Kouzy R, Dyson K, Jafarnia J, Nariman N, Gladish G, New J, Argueta A, Amaya D, Thomas N, Doty A, Chen J, Copling N, Alatrash G, Simon J, Davies AB, Dennis W, Liang R, Lewis J, Wei X, Rinsurongkawong W, Vaporciyan AA, Johns A, D3CODE Team, Lee J, Lee JH, Sun R, Sharma P, Tran H, Zhang J, Gibbons DL, Wargo J, Kim BYS, Heymach JV, Mendez-Gomez HR, Jiang W, Sayour EJ, Lin SH. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade. Nature. 2025;647:488-497. doi: 10.1038/s41586-025-09655-y.

9. Jin Y, Wu Y, Reuben A, Zhu L, Gay CM, Wu Q, Zhou X, Mo H, Zheng Q, Ren J, Fang Z, Peng T, Wang N, Ma L; Lungevity PANSHI Initiative Consortium; Fan Y, Song H, Zhang J, Chen M. Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer. Cell Discov. 2024;10(1):93. doi: 10.1038/s41421-024-00703-x.

10. Li C, Nguyen TT, Li JR, Song X, Fujimoto J, Little L, Gumb C, Chow CB, Wistuba II, Futreal AP, Zhang J, Hubert SM, Heymach JV, Wu J, Amos CI, Zhang J, Cheng C. Multiregional transcriptomic profiling provides improved prognostic insight in localized non-small cell lung cancer. NPJ Precis Oncol. 2024;8(1):225. doi: 10.1038/s41698-024-00680-0.

11. Sujit SJ, Aminu M, Karpinets TV, Chen P, Saad MB, Salehjahromi M, Boom JD, Qayati M, George JM, Allen H, Antonoff MB, Hong L, Hu X, Heeke S, Tran HT, Le X, Elamin YY, Altan M, Vokes NI, Sheshadri A, Lin J, Zhang J, Lu Y, Behrens C, Godoy MCB, Wu CC, Chang JY, Chung C, Jaffray DA, Wistuba II, Lee JJ, Vaporciyan AA, Gibbons DL, Heymach J, Zhang J, Cascone T, Wu J. Enhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights. Nat Commun. 2024;15(1):3152. doi: 10.1038/s41467-024-47512-0.

12. Parra ER, Zhang J, Duose DY, Gonzalez-Kozlova E, Redman MW, Chen H, Manyam GC, Kumar G, Zhang J, Song X, Lazcano R, Marques-Piubelli ML, Laberiano-Fernandez C, Rojas F, Zhang B, Taing L, Jhaveri A, Geisberg J, Altreuter J, Michor F, Provencher J, Yu J, Cerami E, Moravec R, Kannan K, Luthra R, Alatrash G, Huang HH, Xie H, Patel M, Nie K, Harris J, Argueta K, Lindsay J, Biswas R, Van Nostrand S, Kim-Schulze S, Gray JE, Herbst R, Wistuba II, Gettinger S, Kelly K, Bazhenova L, Gnjatic S, Lee JJ, Zhang J, Haymaker C. Multi-omics analysis reveals immune features associated with immunotherapy benefit in squamous cell lung cancer patients from Phase III Lung-MAP S1400I trial. Clin Cancer Res. 2024. doi: 10.1158/1078-0432.CCR-23-0251.

13. Saad MB, Hong L, Aminu M, Vokes NI, Chen P, Salehjahromi M, Qin K, Sujit SJ, Lu X, Young E, Al-Tashi Q, Qureshi R, Wu CC, Carter BW, Lin SH, Lee PP, Gandhi S, Chang JY, Li R, Gensheimer MF, Wakelee HA, Neal JW, Lee HS, Cheng C, Velcheti V, Lou Y, Petranovic M, Rinsurongkawong W, Le X, Rinsurongkawong V, Spelman A, Elamin YY, Negrao MV, Skoulidis F, Gay CM, Cascone T, Antonoff MB, Sepesi B, Lewis J, Wistuba II, Hazle JD, Chung C, Jaffray D, Gibbons DL, Vaporciyan A, Lee JJ, Heymach JV, Zhang J, Wu J. Predicting benefit from immune checkpoint inhibitors in patients with non-small-cell lung cancer by CT-based ensemble deep learning: a retrospective study. Lancet Digit Health. 2023. doi: 10.1016/S2589-7500(23)00082-1.

14. Hong L, Aminu M, Li S, Lu X, Petranovic M, Saad MB, Chen P, Qin K, Varghese S, Rinsurongkawong W, Rinsurongkawong V, Spelman A, Elamin YY, Negrao MV, Skoulidis F, Gay CM, Cascone T, Gandhi SJ, Lin SH, Lee PP, Carter BW, Wu CC, Antonoff MB, Sepesi B, Lewis J, Gibbons DL, Vaporciyan AA, Le X, Lee JJ, Roy-Chowdhuri S, Routbort MJ, Gainor JF, Heymach JV, Lou Y, Wu J, Zhang J, Vokes NI. Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer. Nat Commun. 2023;14(1):695. doi: 10.1038/s41467-023-36328-z.

15. Francisco-Cruz A, Rocha P, Reuben A, Krishnan SN, Das P, Chen R, Quek K, Li J, Parra ER, Solis LM, Barua S, Jiang M, Lazcano R, Chow C, Behrens C, Gumb C, Little L, Fukuoka J, Kalhor N, Weissferdt A, Kadara H, Heymach JV, Swisher S, Sepesi B, Rao A, Moran C, Zhang JH, Lee JJ, Fujimoto J, Futreal PA, Wistuba II, Peterson CB, Zhang J. Analysis of Immune Intratumor Heterogeneity Highlights Immunoregulatory and Coinhibitory Lymphocytes as Hallmarks of Recurrence in Stage I Non-Small Cell Lung Cancer. Mod Pathol. 2023;36:1-11.

16. Chen P, Rojas FR, Hu X, Serrano A, Zhu B, Chen H, Hong L, Bandyopadhyay R, Aminu M, Kalhor N, Lee JJ, El Hussein S, Khoury JD, Pass HI, Moreira AL, Velcheti V, Sterman DH, Fukuoka J, Tabata K, Su D, Ying L, Gibbons DL, Heymach JV, Wistuba II, Fujimoto J, Solis Soto LM, Zhang J, Wu J. Pathomic Features Reveal Immune and Molecular Evolution from Lung Preneoplasia to Invasive Adenocarcinoma. Mod Pathol. 2023;36:100326. doi: 10.1016/j.modpat.2023.100326.

17. Chen M, Chen R, Jin Y, Li J, Hu X, Zhang J, Fujimoto J, Hubert SM, Gay CM, Zhu B, Tian Y, McGranahan N, Lee WC, George J, Hu X, Chen Y, Wu M, Behrens C, Chow CW, Pham HHN, Fukuoka J, Wu J, Parra ER, Little LD, Gumbs C, Song X, Wu CJ, Diao L, Wang Q, Cardnell R, Zhang J, Wang J, Le X, Gibbons DL, Heymach JV, Lee JJ, William WN Jr, Cheng C, Glisson B, Wistuba I, Futreal PA, Thomas RK, Reuben A, Byers LA, Zhang J. Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer. Nat Commun. 2021;12(1):6655. doi: 10.1038/s41467-021-26821-8.

18. Dejima H, Hu X, Chen C, Zhang J, Junya J, Parra E, Haymaker C, Duose D, Solis S, Su D, Fukuoka J, Pham H, McGranahan N, Zhang B, Ying L, Little L, Gumbs C, Chow C, Estecio M, Godoy M, Antonoff M, Sepesi B, Pass H, Behrens C, Zhang J, Heymach J, Scheet P, Lee J, Futreal PA, Reuben A, Kadara H, Wistuba I, Zhang J. Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features. Nat Commun. 2021;12:2722. doi: 10.1038/s41467-021-22890-x.

19. Hu X, Estecio M, Chen R, Reuben A, Wang L, Fujimoto J, Ying L, Chow C, McGranahan N, Pham H, Godoy M, Brett C, Behrens C, Zhang J, Vaporciyan A, Heymach J, Wistuba I, Lu Y, Pass H, Kadara H, Scheet P, Lee J, Futreal A, Su D, Issa J, Zhang J. Evolution of the DNA methylome from precancer to invasive lung adenocarcinoma. Nat Commun. 2021;12(1):687. doi: 10.1038/s41467-021-20907-z.

20. Lee WC, Reuben A, Hu X, McGranahan N, Chen R, Jalali A, Negrao M, Hubert S, Tang C, Wu C, Lucas A, Roh W, Suda K, Kim J, Tan A, Peng D, Lu W, Tang X, Chow C, Fujimoto J, Behrens C, Kalhor N, Fukumura K, Coyle M, Thornton R, Gumb C, Li J, Wu C, Little L, Roarty E, Song X, Lee J, Sulman E, Rao G, Swisher S, Diao L, Wang J, Heymach J, Huse J, Scheet P, Wistuba I, Gibbons D, Futreal PA, Zhang JH, Gomez D, Zhang J. Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity. Genome Biol. 2020;21(1):271. doi: 10.1186/s13059-020-02175-0.

21. Reuben A, Zhang JX, Chiou SH, Gittelman RM, Li J, Lee WC, Fujimoto J, Behrens C, Liu X, Wang F, Quek K, Wang C, Kheradmand F, Chen R, Chow CW, Lin H, Bernatchez C, Jalali A, Hu X, Wu CJ, Eterovic AK, Parra ER, Yusko E, Emerson R, Benzeno S, Vignali M, Wu X, Ye Y, Little L, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Cascone T, Snyder A, Wargo JA, Herbst R, Swisher S, Kadara H, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons DL, Robins H, Hwu P, Heymach JV, Sharma P, Allison JP, Baladandayuthapani V, Lee JJ, Davis MM, Wistuba II, Futreal PA, Zhang J. Comprehensive T cell repertoire characterization of non-small cell lung cancer. Nat Commun. 2020;11(1):603.

22. Hu X, Fujimoto J, Ying L, Fukuoka J, Ashizawa K, Sun W, Reuben A, Chow CW, McGranahan N, Chen R, Hu J, Godoy MC, Tabata K, Kuroda K, Shi L, Li J, Behrens C, Parra ER, Little LD, Gumbs C, Mao X, Song X, Tippen S, Thornton RL, Kadara H, Scheet P, Roarty E, Ostrin EJ, Wang X, Carter BW, Antonoff MB, Zhang J, Vaporciyan AA, Pass H, Swisher SG, Heymach JV, Lee JJ, Wistuba II, Hong WK, Futreal PA, Su D, Zhang J. Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. Nat Commun. 2019;10(1):2978.

23. Reuben A, Gittelman R, Gao J, Zhang JX, Yusko EC, Wu CJ, Emerson R, Zhang J, Tipton C, Li J, Quek K, Gopalakrishnan V, Chen R, Vence LM, Cascone T, Vignali M, Fujimoto J, Rodriguez-Canales J, Parra ER, Little LD, Gumbs C, Forget MA, Federico L, Haymaker C, Behrens C, Benzeno S, Bernatchez C, Sepesi B, Gibbons DL, Wargo JA, William WN, Swisher S, Heymach JV, Robins H, Lee JJ, Sharma P, Allison JP, Futreal PA, Wistuba II, Zhang J. TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence. Cancer Discov. 2017;7(10):1088-1097.

24. Liu Y, Zhang J, Li L, Yin G, Zhang JH, Zheng S, Cheung H, Wu N, Lu N, Mao X, Yang L, Zhang J, Zhang L, Seth S, Chen H, Song X, Liu K, Xie Y, Zhou L, Zhao C, Han N, Chen W, Zhang S, Chen L, Cai W, Li L, Shen M, Xu N, Cheng S, Yang H, Lee J, Correa A, Fujimoto J, Behrens C, Chow C, William W, Heymach J, Hong W, Swisher S, Wistuba I, Wang J, Lin D, Liu X, Futreal PA, Gao Y. Genomic heterogeneity of multiple synchronous lung cancer. Nat Commun. 2016;7:13200.

25. Zhang J, Fujimoto J, Zhang JH, Wedge DC, Song X, Zhang J, Seth S, Chow CW, Cao Y, Gumbs C, Gold KA, Kalhor N, Little L, Mahadeshwar H, Moran C, Protopopov A, Sun H, Tang J, Wu X, Ye Y, William WN, Lee JJ, Heymach JV, Hong WK, Swisher S, Wistuba II, Futreal PA. Intra-tumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multi-region Sequencing. Science. 2014;346(6206):256-259.

Suggested footer for the website: For a complete and current list of publications, please visit Dr. Jianjun Zhang's PubMed or MD Anderson faculty profile.