Yoon Laboratory
Hojong Yoon, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Yoon Laboratory
Areas of Research
- Chemical Biology
- Targeted Protein Degradation
- Drug Development
- Biochemistry
- Proteomics
- Structural Biology
- Immunology
The Yoon Lab focuses on developing innovative small-molecule drugs to target previously undruggable proteins and to elucidate drug mechanisms at the molecular level. By integrating chemical biology, protein biochemistry, medicinal chemistry, functional genomics and proteomics, the lab aims to develop new small molecules that induce novel protein-protein interactions, opening new avenues for therapeutic intervention and redefining "druggability."
Featured Publications
Yoon H#, Wachter# et al., DCAF11-dependent molecular glue degrader activated by glutathionylation. Nature 2026 (accepted)
Słabicki M#, Yoon H#, Koeppel J# et al., Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020
Faust TB#, Yoon H# et al., Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol. 2020
Our Funding
CPRIT Recruitment of First-Time Tenure-Track Faculty Award
(2024–)
UT MD Anderson Start-up Fund Award
(2025–)
UT System Rising STARs award
(2025–)
The Allison Institute Research Start-up Funds
(2025–)
NIH/NCI 1R00CA287069
(2025–)
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Research Areas
Find out about the four types of research taking place at UT MD Anderson.