Stephanie S. Watowich
The Watowich lab investigates the molecular regulation of innate immune cell development and function. The innate immune system is the front line defense against pathogens, is a central mediator of inflammation, and is critical for the initiation and education of the adaptive immune response. In cancer, innate immune cells can either promote or restrain malignant tumor growth, with outcomes depending on molecular cues received in the tumor environment. Our goal is to improve understanding of the molecular mechanisms by which innate immune cells are regulated, to advance fundamental knowledge and to inform new therapies for cancer and immune disease.
Meet the team
From left to right: Yifan Zhou, Rachel Babcock, Natalie Slone, Taylor Chrisikos, Haiyan Li, and Stephanie Watowich.
Our primary interest is understanding transcriptional control of innate immune cell development and function by cytokine-activated STAT proteins. Major projects in our laboratory focus on mechanisms by which STATs regulate myeloid and dendritic cell activity in tumors, the anti-inflammatory function of STAT3 in hematopoiesis, and whether and how STATs contribute to immune adverse events in cancer immunotherapy.