Watowich Laboratory

The Watowich lab investigates the molecular regulation of innate immune cell development and function. The innate immune system is the front line defense against pathogens, is a central mediator of inflammation, and is critical for the initiation and education of the adaptive immune response. In cancer, innate immune cells can either promote or restrain malignant tumor growth, with outcomes depending on molecular cues received in the tumor environment. Our goal is to improve understanding of the molecular mechanisms by which innate immune cells are regulated, to advance fundamental knowledge and to inform new therapies for cancer and immune disease.