Publications

Ban I, Tomasic L, Trakala M, Tolic IM, Pavin N. Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes. Biophys J. 2023 Feb 21; 122(4):632-645. PMID: 36654508 PMCID: PMC9989886.

Villarroya-Beltri C, Osorio A, Torres-Ruiz R, Gomez-Sanchez D, Trakala M, Sanchez-Belmonte A, Mercadillo F, Hurtado B, Pitarch B, Hernandez-Nunez A, Gomez-Caturla A, Rueda D, Perea J, Rodriguez-Perales S, Malumbres M, Urioste M. Biallelic germline mutations in MAD1L1 induce a syndrome of aneuploidy with high tumor susceptibility. Sci Adv. 2022 Nov 04; 8(44):eabq5914. PMID: 36322655 PMCID: PMC9629740.

Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ, Zhong J, Hsu PH, Paradis G, Ried T, Holland A, Van Deursen J, Amon A. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev. 2021 Aug 01; 35(15-16):1079-1092. PMID: 34266888 https://doi.org/10.1101/gad.348341.121.

Salazar-Roa M, Trakala M, Alvarez-Fernandez M, Valdes-Mora F, Zhong C, Munoz J, Yu Y, Peters TJ, Grana-Castro O, Serrano R, Zapatero-Solana E, Abad M, Bueno MJ, Gomez de Cedron M, Fernandez-Piqueras J, Serrano M, Blasco MA, Wang DZ, Clark SJ, Izpisua-Belmonte JC, Ortega S, Malumbres M. Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells. EMBO J. 2020 Aug 17; 39(16):e104324. PMID: 32614092 https://doi.org/10.15252/embj.2019104324.

Marjanovic ND, Hofree M, Chan JE, Canner D, Wu K, Trakala M, Hartmann GG, Smith OC, Kim JY, Evans KV, Hudson A, Ashenberg O, Porter CBM, Bejnood A, Subramanian A, Pitter K, Yan Y, Delorey T, Phillips DR, Shah N, Chaudhary O, Tsankov A, Hollmann T, Rekhtman N, Massion PP, Poirier JT, Mazutis L, Li R, Lee JH, Amon A, Rudin CM, Jacks T, Regev A, Tammela T. Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. Cancer Cell. 2020 Aug 10; 38(2):229-246.e13. PMID: 32707077 https://doi.org/10.1016/j.ccell.2020.06.012.

Tomas-Loba A, Manieri E, Gonzalez-Teran B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodriguez E, Pintor-Chocano A, Feixas F, Lopez JA, Caballero B, Trakala M, Blanco O, Torres JL, Hernandez-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, Leon M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vazquez J, Malumbres M, Marcos M, Osuna S, Sabio G. p38gamma is essential for cell cycle progression and liver tumorigenesis. Nature. 2019 Apr; 568(7753):557-560. PMID: 30971822 https://doi.org/10.1038/s41586-019-1112-8.

Hurtado B, Trakala M, Ximenez-Embun P, El Bakkali A, Partida D, Sanz-Castillo B, Alvarez-Fernandez M, Maroto M, Sanchez-Martinez R, Martinez L, Munoz J, Garcia de Frutos P, Malumbres M. Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J Clin Invest. 2018 Dec 03; 128(12):5351-5367. PMID: 30252678 https://doi.org/10.1172/JCI121876.

Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Cancer Res. 2017 Oct 01; 77(19):5272-5286. PMID: 28775166 https://doi.org/10.1158/0008-5472.CAN-17-0049.

Trakala M, Partida D, Salazar-Roa M, Maroto M, Wachowicz P, de Carcer G, Malumbres M. Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood. 2015 Oct 01; 126(14):1707-14. PMID: 26185128 https://doi.org/10.1182/blood-2015-03-634402.

Gonzalez-Loyola A, Fernandez-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Canamero M, de Martino A, Martinez-Ramirez A, de Carcer G, Perez de Castro I, Earnshaw WC, Malumbres M. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol. 2015 Oct; 35(20):3566-78. PMID: 26240282 https://doi.org/10.1128/MCB.01286-14.

Di Pilato M, Mejias-Perez E, Zonca M, Perdiguero B, Gomez CE, Trakala M, Nieto J, Najera JL, Sorzano CO, Combadiere C, Pantaleo G, Planelles L, Esteban M. NFkappaB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1333-42. PMID: 25739961 https://doi.org/10.1073/pnas.1424341112.

Trakala M, Rodriguez-Acebes S, Maroto M, Symonds CE, Santamaria D, Ortega S, Barbacid M, Mendez J, Malumbres M. Functional reprogramming of polyploidization in megakaryocytes. Dev Cell. 2015 Jan 26; 32(2):155-67. PMID: 25625205 https://doi.org/10.1016/j.devcel.2014.12.015.

Trakala M, Malumbres M. Cyclin C surprises in tumour suppression. Nat Cell Biol. 2014 Nov; 16(11):1031-3. PMID: 25358351 https://doi.org/10.1038/ncb3055.

Trakala M, Malumbres M. The functional relevance of polyploidization in the skin. Exp Dermatol. 2014 Feb; 23(2):92-3. PMID: 24330335 https://doi.org/10.1111/exd.12305.

Alvarez-Fernandez M, Sanchez-Martinez R, Sanz-Castillo B, Gan PP, Sanz-Flores M, Trakala M, Ruiz-Torres M, Lorca T, Castro A, Malumbres M. Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17374-9. PMID: 24101512 https://doi.org/10.1073/pnas.1310745110.

Trakala M, Fernandez-Miranda G, Perez de Castro I, Heeschen C, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell Cycle. 2013 Apr 01; 12(7):1030-41. PMID: 23428904 https://doi.org/10.4161/cc.24004.

Kakani EG, Trakala M, Drosopoulou E, Mavragani-Tsipidou P, Mathiopoulos KD. Genomic structure, organization and localization of the acetylcholinesterase locus of the olive fruit fly, Bactrocera oleae. Bull Entomol Res. 2013 Feb; 103(1):36-47. PMID: 22967668 https://doi.org/10.1017/S0007485312000478.

Fernandez-Miranda G, Trakala M, Martin J, Escobar B, Gonzalez A, Ghyselinck NB, Ortega S, Canamero M, Perez de Castro I, Malumbres M. Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development. 2011 Jul; 138(13):2661-72. PMID: 21613325 https://doi.org/10.1242/dev.066381.

Trakala M, Arias CF, Garcia MI, Moreno-Ortiz MC, Tsilingiri K, Fernandez PJ, Mellado M, Diaz-Meco MT, Moscat J, Serrano M, Martinez-A C, Balomenos D. Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1). Eur J Immunol. 2009 Mar; 39(3):810-9. PMID: 19224635 https://doi.org/10.1002/eji.200838676.

Kolonitsiou F, Mani V, Parikou H, Trakala M, Dimitracopoulos G, Spiliopoulou I. The emergence of glycopeptide-resistant Enterococcus faecium in a university hospital in southwestern Greece. Chemotherapy. 2004 Nov; 50(5):245-9. PMID: 15528890.