Publications
Chandra V, McAllister F. Therapeutic potential of microbial modulation in pancreatic cancer. Gut Published Online First: 27 April 2021. doi: 10.1136/gutjnl-2019-319807
Kanchan Singh, Melissa Pruski, Rachael Bland, Mamoun Younes, Sushovan Guha, Nirav Thosani, Anirban Maitra, Brooks D. Cash, Florencia McAllister, Craig D. Logsdon, Jeffrey T. Chang & Jennifer M. Bailey-Lundberg. Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer. Lab Invest 101, 177–192 (2021).
Michael P Kim, Xinqun Li, Jenying Deng, Yun Zhang, Bingbing Dai, Kendra L Allton, Tara G. Hughes, Christian Siangco, Jithesh
J. Augustine, Ya'an Kang, Joy M McDaniel, Shunbin Xiong, EugeneJ Koay, Florencia McAllister, Christopher, Bristow, Timothy, Heffernan, Anirban Maitra, Bin Liu, Michelle
C. Barton, Amanda R Wasylishen, Jason B. Fleming and Guillermina Lozano. Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis. Cancer Discov April 10 2021 DOI: 10.1158/2159-8290.CD-20-1228
Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, Michelle Zoltan, Nivedita Arora, Seyda Baydogan, William Horne, Jared Burks, Hanwen Xu, Perwez Hussain, Huamin Wang, Sonal Gupta, Anirban Maitra, Jennifer M. Bailey, Seyed J. Moghaddam, Sulagna Banerjee, Ismet Sahin, Pratip Bhattacharya, Florencia McAllister. Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 7 December 2020; 217 (12): e20190354. doi: https://doi.org/10.1084/jem.20190354
Betsy J Barnes, Jose M Adrover, Amelia Baxter-Stoltzfus, Alain Borczuk, Jonathan Cools-Lartigue, James M Crawford, Juliane Daßler-Plenker, Philippe Guerci, Caroline Huynh, Jason S Knight, Massimo Loda, Mark R Looney, Florencia McAllister, Roni Rayes, Stephane Renaud, Simon Rousseau, Steven Salvatore, Robert E Schwartz, Jonathan D Spicer, Christian C Yost, Andrew Weber, Yu Zuo, Mikala Egeblad. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. Journal of Experimental Medicine 217(6):e20200652, 2020. PMID: 32302401
Vidhi Chandra, Olivereen Le Roux, Erick Riquelme, Yu Zhang, Anirban Maitra, James R White, Florencia McAllister. Elucidating role of bacteria during pancreatic ductal adenocarcinoma (PDAC). Cancer Research 80(8):27, 2020.
Jennifer B Goldstein, Li Zhao, Xuemei Wang, Yael Ghelman, Michael J Overman, Milind M Javle, Rachna T Shroff, Gauri R Varadhachary, Robert A Wolff, Florencia McAllister, Andrew Futreal, David R Fogelman. Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer. Clinical Cancer Research 26(6):1385-1394, 2020. PMID: 31871297
JJ Lee, L Prakash, M Bhutani, JH Lee, E Coronel, P Ge, B Weston, WA Ross, E Koay, P Bhosale, EP Tamm, F McAllister, J Vauthey, N Ikoma, CD Tzeng, A Maitra, M Katz, JE Lee, P Kim. Longitudinal Observation of Side-branch IPMN Patients Reveals Malignant Transformation as a Low-frequency Event. Annals of Surgical Oncology 27(1):S22, 2020.
Matthew B Yurgelun, Chinedu I Ukaegbu, C Sloane Furniss, Barbara Kenner, Alison Klein, Andrew M Lowy, Florencia McAllister, Maureen E Mork, Scott H Nelson, Alison Robertson, Jill E Stopfer, Meghan Underhill, Allyson J Ocean, Lisa Madlensky, Gloria M Petersen, Judy Ellen Garber, Scott Michael Lippman, Michael Goggins, Anirban Maitra, Sapna Syngal. Improving cascade genetic testing for families with inherited pancreatic cancer (PDAC) risk: The GENetic Education, Risk Assessment and TEsting (GENERATE) study. Journal of Clinical Oncology 38(4):TPS779, 2020.
Ana De Jesus-Acosta, Elizabeth A Sugar, Peter J O’Dwyer, Ramesh K Ramanathan, Daniel D Von Hoff, Zeshaan Rasheed, Lei Zheng, Asma Begum, Robert Anders, Anirban Maitra, Florencia McAllister, NV Rajeshkumar, Shinichi Yabuuchi, Roeland F De Wilde, Bhavina Batukbhai, Ismet Sahin, Daniel A Laheru. Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma. British Journal of Cancer 122(4):498-505, 2020. PMID: 31857726
Prasanta Dutta, Susana Castro Pando, Marilina Mascaro, Erick Riquelme, Michelle Zoltan, Niki M Zacharias, Seth T Gammon, David Piwnica-Worms, Mark D Pagel, Subrata Sen, Anirban Maitra, Shayan Shams, Florencia McAllister, Pratip K Bhattacharya. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. International Journal of Molecular Sciences 21(10):3722, 2020. PMID: 32466260
Irina M Cazacu, Adriana A Luzuriaga Chavez, Tito R Mendoza, Wei Qiao, Ben S Singh, Raza H Bokhari, Adrian Saftoiu, Jeffrey H Lee, Brian Weston, John R Stroehlein, Michael P Kim, Matthew HG Katz, Anirban Maitra, Florencia McAllister, Manoop S Bhutani. Quality of life impact of EUS in patients at risk for developing pancreatic cancer. Endoscopic Ultrasound 9(1):53-58, 2020. PMID: 31552914
Jennifer B Goldstein, Li Zhao, Xuemei Wang, Yael Ghelman, Michael J Overman, Milind M Javle, Rachna T Shroff, Gauri R Varadhachary, Robert A Wolff, Florencia McAllister, Andrew Futreal, David R Fogelman. Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer. Clinical Cancer Research 26(6):1385-1394, 2020 PMID: 31871297
Florencia McAllister, Md Abdul Wadud Khan, Beth Helmink, Jennifer A Wargo, The Tumor Microbiome in Pancreatic Cancer: Bacteria and Beyond, Cancer Cell35(6):577-579, 2019. PMID: 31951558
Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell 178(4):795-806.e12, 2019. PMID: 31398337.
Vreeland TJ, McAllister F, Javadi S, Prakash LR, Fogelman DR, Ho L, Varadhachary G, Aloia TA, Vauthey JN, Lee JE, Kim MP, Katz MHG, Tzeng CD. Benefit of Gemcitabine/Nab-Paclitaxel Rescue of Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma After Early Failure of FOLFIRINOX. Pancreas 48(6):837-843, 2019. PMID: 31210666.
Mork M, Quesada PR, Bannon S, Montiel MF, Fleming JB, Lynch PM, Bhutani MS, Lee JH, McAllister F. Pancreatic Cancer Early Detection and Interception in an Atypical Case of Peutz-Jeghers Syndrome. Pancreas 48(4):e29-e30, 2019. PMID: 30973470.
Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. e-Pub 2019. PMID: 30978984.
Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, Diodoro MG, You YN, Hawk ET, Roszik J, Scheet P, Kopetz S, Nicosia A, Scarselli E, Lynch PM, McAllister F, Vilar E. Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome. JAMA Oncol 4(8):1085-1092, 2018. PMID: 29710228.
Bannon SA, Montiel MF, Goldstein JB, Dong W, Mork ME, Borras E, Hasanov M, Varadhachary GR, Maitra A, Katz MH, Feng L, Futreal A, Fogelman DR, Vilar E, McAllister F. High Prevalence of Hereditary Cancer Syndromes and Outcomes in Adults with Early-Onset Pancreatic Cancer. Cancer Prev Res 11(11):679-686, 2018. e-Pub 2018. PMID: 30274973.
Riquelme E, Maitra A, McAllister F. Immunotherapy for Pancreatic Cancer: More Than Just a Gut Feeling. Cancer Discovery 8(4):386-388. PMID:29610286
Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology 155(1):210-223.e3, 2018. e-Pub 2018. PMID: 29699936.
Unver N, McAllister F. IL-6 Family Cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev 41:10-17, 2018. e-Pub 2018. PMID: 29699936.
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe 23(2):203-214.e5, 2018. e-Pub 2018. PMID: 29398651.
Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359(6371):97-103, 2018. e-Pub 2017. PMID: 29097493
Sahin I, Zhang Y, McAllister F. Tumor Spheres Quantification with Smoothed Euclidean Distance Transform. J Mol Imaging Dyn 8(1), 2018. e-Pub 2018. PMID: 30319887
Bengsch F, Knoblock DM, Liu A, McAllister F, Beatty GL. CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. Cancer Immunol Immunother. e-Pub 8/2017. PMID: 28856392.
McAllister F, Montiel MF, Uberoi GS, Uberoi AS, Maitra A, Bhutani MS. Current Status and Future Directions for Screening Patients at High Risk for Pancreatic Cancer. Gastroenterol Hepatol (N Y) 13(5):268-275, 5/2017. PMCID: PMC5479340.
Borras E, San Lucas FA, Chang K, Zhou R, Masand G, Fowler J, Mork ME, You YN, Taggart MW, McAllister F, Jones DA, Davies GE, Edelmann W, Ehli EA, Lynch PM, Hawk ET, Capella G, Scheet P, Vilar E. Genomic Landscape of Colorectal Mucosa and Adenomas. Cancer Prev Res (Phila) 9(6):417-27, 6/2016. e-Pub 5/2016. PMID: 27221540.
Roeser JC, Leach SD, McAllister F. Emerging strategies for cancer immunoprevention. Oncogene 34(50):6029-39, 12/2015. e-Pub 9/2015. PMID: 26364615.
Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene. e-Pub 11/2015. PMID: 26592447.
McAllister F, Kolls JK. Th17 cytokines in non-melanoma skin cancer. Eur J Immunol 45(3):692-4, 3/2015. PMID: 25655439.
Zhang Y, McAllister F, Pasca di Magliano M. Immune cells in pancreatic cancer: Joining the dark side. Oncoimmunology 3:e29125, 2014. e-Pub 6/2014. PMCID: PMC4108467.
Wang YJ, McAllister F, Bailey JM, Scott SG, Hendley AM, Leach SD, Ghosh B. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS One 9(11):e113127, 2014. e-Pub 11/2014. PMCID: PMC4236134.
Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, Goh KL, Thevambiga I, Fu K, Wan F, Llosa N, Housseau F, Romans K, Wu X, McAllister FM, Wu S, Vogelstein B, Kinzler KW, Pardoll DM, Sears CL. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A 111(51):18321-6, 12/2014. e-Pub 12/2014. PMCID: PMC4280621.
McAllister F, Leach SD. Targeting IL-17 for pancreatic cancer prevention. Oncotarget 5(20):9530-1, 10/2014. PMCID: PMC4259416.
McAllister F, Pineda DM, Jimbo M, Lal S, Burkhart RA, Moughan J, Winter KA, Abdelmohsen K, Gorospe M, Acosta Ade J, Lankapalli RH, Winter JM, Yeo CJ, Witkiewicz AK, Iacobuzio-Donahue CA, Laheru D, Brody JR. dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial. Cancer Biol Ther 15(6):688-98, 6/2014. e-Pub 3/2014. PMCID: PMC4049785.
McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell 25(5):621-37, 5/2014. PMCID: PMC4072043.
McAllister F, Housseau F, Sears CL. Microbiota and immune responses in colon cancer: more to learn. Cancer J 20(3):232-6, May-Jun, 5/2014. PMID: 24855013.
Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ, Bardeesy N, Matsui W, Maitra A, Leach SD. DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology 146(1):245-56, 1/2014. e-Pub 10/2013. PMCID: PMC3910427.
Laheru D, Shah P, Rajeshkumar NV, McAllister F, Taylor G, Goldsweig H, Le DT, Donehower R, Jimeno A, Linden S, Zhao M, Song D, Rudek MA, Hidalgo M. Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. Invest New Drugs 30(6):2391-9, 12/2012. e-Pub 5/2012. PMCID: PMC3557459.
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. EMT and dissemination precede pancreatic tumor formation. Cell 148(1-2):349-61, 1/2012. PMCID: PMC3266542.
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 15(9):1016-22, 9/2009. e-Pub 8/2009. PMCID: PMC3034219.
Zhong W, Kolls JK, Chen H, McAllister F, Oliver PD, Zhang Z. Chemokines orchestrate leukocyte trafficking in inflammatory bowel disease. Front Biosci 13:1654-64, 2008. e-Pub 1/2008. PMID: 17981657.
Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14(3):275-81, 3/2008. e-Pub 2/2008. PMCID: PMC2901867.
Dubin PJ, McAllister F, Kolls JK. Is cystic fibrosis a TH17 disease? Inflamm Res 56(6):221-7, 6/2007. PMID: 17607545.
McKinley L, Logar AJ, McAllister F, Zheng M, Steele C, Kolls JK. Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia. J Immunol 177(9):6215-26, 11/2006. PMCID: PMC3912571.
McAllister F, Ruan S, Steele C, Zheng M, McKinley L, Ulrich L, Marrero L, Shellito JE, Kolls JK. CXCR3 and IFN protein-10 in Pneumocystis pneumonia. J Immunol 177(3):1846-54, 8/2006. PMCID: PMC3912555.
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 175(9):6177-89, 11/2005. PMID: 16237115.
McAllister F, Henry A, Kreindler JL, Dubin PJ, Ulrich L, Steele C, Finder JD, Pilewski JM, Carreno BM, Goldman SJ, Pirhonen J, Kolls JK. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 175(1):404-12, 7/2005. PMCID: PMC2849297.
McAllister F, Steele C, Zheng M, Young E, Shellito JE, Marrero L, Kolls JK. T cytotoxic-1 CD8+ T cells are effector cells against pneumocystis in mice. J Immunol 172(2):1132-8, 1/2004. PMID: 14707088.