Selected Publications
2024 (9)
84. Abraham RJ, Arepally A, Liu D, Lewandowski R, Kappadath SC, Verma A, Dobrowski D, Holden A. Imageable Radioembolization Microspheres for Treatment of Unresectable Hepatocellular Carcinoma: Interim Results from a First-in-Human Trial. J Vasc Interv Radiol. 35(10):1464-1473.e1, 2024. DOI
83. Gonzalez F, Scott PJH, Jeffers CD, Kappadath SC. SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials. J Nucl Med Technol. 52(3):184-191, 2024. DOI
82. Lopez BP, Kappadath SC. (90)Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit. J Nucl Med Technol. 52(3):256-260, 2024. DOI
81. Kappadath SC, Henry EC, Lopez BP, Mahvash A. Quantitative evaluation of (90)Y-PET/CT and (90)Y-SPECT/CT-based dosimetry following Yttrium-90 radioembolization. Med Phys. 51(9):6061-6074, 2024. DOI
80. Henry EC, Mahvash A, Lopez BP, Kappadath SC. A comparison of methods for in vivo activity and absorbed dose quantification with PET/CT following yttrium-90 radioembolization. Med Phys. 51(9):6034-6045, 2024. DOI
79. Kokabi N, Webster LA, Dabbous H, Shah A, Brandon D, Galt J, Xing M, Villalobos A, Davarpanahfakhr A, Kappadath SC, Schuster DM. Resin-Based 90 Y Tumor Dose as a Predictor of Duration of Response and Survival in Patients With Surgically Unresectable Hepatocellular Carcinoma: A Prospective Single-Arm Study. Clin Nucl Med. 49(9):799-805, 2024. DOI
78. MGEH L, Kappadath SC. Need for a Practical Dosimetry Paradigm That Incorporates Dose Heterogeneity. J Vasc Interv Radiol. 35(6):919-921, 2024. DOI
77. Keane G, van Rooij R, Lam M, Kappadath SC, Kovan B, Leon S, Dreher M, Fowers K, de Jong H. An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study. EJNMMI Phys. 11(1):46, 2024. DOI
76. Kappadath SC. Retrospective dosimetry for yttrium-90 radioembolization with resin microspheres. J Vasc Interv Radiol. 35(5):709-711, 2024. DOI
2023 (8)
75. Lam M, Garin E, Palard-Novello X, Mahvash A, Kappadath SC, Haste P, Tann M, Herrmann K, Barbato F, Geller B, Schaefer N, Denys A, Dreher M, Fowers KD, Gates V, Salem R. Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma. Eur J Nucl Med Mol Imaging 51(1):245-257, 2023. DOI
74. Salem R, Padia SA, Lam M, Chiesa C, Haste P, Sangro B, Toskich B, Fowers K, Herman JM, Kappadath SC, Leung T, Sze DY, Kim E, Garin E. Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 50(2):328-343, 2023. DOI
73. Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Absolute tumor activity. Med Phys 50(5):2985-2997, 2023. DOI
72. Kappadath SC, Lopez BP. Single-Compartment Dose Prescriptions for Ablative 90Y-Radioembolization Segmentectomy. Life 13(6), 2023. DOI
71. Kokabi N, Arndt-Webster L, Chen B, Brandon D, Sethi I, Davarpanahfakhr A, Galt J, Elsayed M, Bercu Z, Cristescu M, Kappadath SC, Schuster DM. Voxel-based dosimetry predicting treatment response and related toxicity in HCC patients treated with resin-based Y90 radioembolization: a prospective, single-arm study. Eur J Nucl Med Mol Imaging 50(6):1743-1752, 2023. DOI
70. Henry EC, Lopez B, Mahvash A, Thomas MA, Kappadath SC. Predicting the net administered activity in 90 Y-radioembolization patients from post-procedure 90 Y-SPECT/CT. Med Phys 50(11):7003-7015, 2023. DOI
69. Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Tumor and breast activity concentrations. Med Phys 50(5):2985-2997, 2023. DOI
68. Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Karnia JJ, Abraham R, Kappadath SC, Syme A. Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 10(1):74, 2023. DOI
2022 (11)
67. Kairemo K, Kangasmäki A, Kappadath SC, Joensuu T, Macapinlac HA. A retrospective comparative study of sodium fluoride Na18F-PET/CT and 68Ga-PSMA-11 PET/CT in the bone metastases of prostate cancer using a volumetric 3-D radiomic analysis. Life 12(12):1977, 2022. DOI
66. Lopez BP, Rauch GM, Adrada B, Kappadath SC. Functional tumor diameter measurement with molecular breast imaging: development and clinical application. Biomed Phys Eng Express 8(5), 2022. DOI
65. Kappadath SC, Lopez BP. Organ-level internal dosimetry for intra-hepatic-arterial administration of 99mTc-macroaggregated albumin. Med Phys 49(8):5504-5512, 2022. DOI
64. Broyles JM, Smith JM, Wong FC, Hanasono MM, Chang El, Kappadath SC, Schaverien MV. Single-photon emission computed tomographic reverse lymphatic mapping for groin vascularized lymph node transplant planning. Plast Reconstr Surg 150(4):869e-879e, 2022. DOI
63. Hruska CB, Corion C, de Geus-Oei LF, Adrada BE, Fowler AM, Hunt KN, Kappadath SC, Pilkington P, Arias-Bouda LMP, Rauch GM. SNMMI procedure standard/EANM practice guideline for molecular breast imaging with dedicated gamma cameras. J Nucl Med Technol 50(2):103-110, 2022. DOI
62. Sharma NK, Kappadath SC, Chuong M, Folkert M, Gibbs P, Jabbour SK, Jeyarajah DR, Kennedy A, Liu D, Meyer JE, Mikell J, Patel RS, Yang G, Mourtada F. The American Brachytherapy Society consensus statement for permanent implant brachytherapy using Yttrium-90 microsphere radioembolization for liver tumors. Brachytherapy 21(5):569-591, 2022. DOI
61. Lopez BP, Mahvash A, Long JP, Lam MGEH, Kappadath SC. Factors modulating 99mTc-MAA planar lung dosimetry for 90Y-radioembolization. J Appl Clin Med Phys 23(12):e13734, 2022. DOI
60. Kokabi N, Webster LA, Elsayed M, Switchenko JM, Chen B, Brandon D, Galt J, Sethi I, Cristescu M, Kappadath SC, Schuster DM. Accuracy and Safety of Scout Dose Resin Yttrium-90 Microspheres for Radioembolization Therapy Treatment Planning: A Prospective Single-Arm Clinical Trial. J Vasc Interv Radiol 33(12):1578-1587, 2022. DOI
59. Mahvash A, Chartier S, Turco M, Habib P, Griffith S, Brown S, Kappadath SC. A prospective, multicenter, open-label, single-arm clinical trial design to evaluate the safety and efficacy of 90Y resin microspheres for the treatment of unresectable HCC: the DOORwaY90 (Duration Of Objective Response with arterial Ytrrium-90). BMC Gastroenterol 22(1):151, 2022. DOI
58. Lam M, Garin E, Maccauro M, Kappadath SC, Sze DY, Turkmen C, Cantasdemir M, Haste P, Herrmann K, Alsuhaibani KS, Dreher M, Fowers KD, Salem R. A global evaluation of advanced dosimetry in transarterial radioembolization of hepatocellular carcinoma with Yttrium-90: the TARGET study. Eur J Nucl Med Mol Imaging 49(1):3340-3352, 2022. DOI
57. Henry EC, Strugari M, Mawko G, Brewer KD, Liu D, Gordon AC, Bryan JN, Maitz C, Abraham R, Kappadath SC, Syme A. Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 9(1):21, 2022. DOI
2021 (9)
56. Kappadath SC, Lopez BP, Salem R, Lam MGEH. Reassessment of the lung dose limits for radioembolization. Nucl Med Comm 42(10):1064–1075, 2021.
55. Henry EC, Strugari M, Mawko G, Brewer KD, Abraham R, Kappadath SC, Syme A. Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model. Phys Med Biol 66:095011, 2021. DOI
54. Lopez BP, Guan F, Rauch GM, Kappadath SC. Monte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system. Phys Med Biol 66:125009, 2021. DOI
53. Kappadath SC, Lopez BP, Salem R, Lam MGEH. Lung shunt and lung dose calculation methods for radioembolization treatment planning. Q J Nucl Med Mol Imaging 65(1):32-42, 2021. DOI
52. Levillain H, Bagni O, Deroose CM, Dieudonne A, Gnessin S, Grosser OS, Kappadath SC, Kennedy A, Kokabi N, Liu DM, Madoff DC, Mahvash A, Martinez A, Ng D, Paprottka P, Pettinato C, Rodríguez-Fraile M, Salem R, Sangro B, Strigari L, Sze DY, deWit B, Flamer P. International recommendations for personalized selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. Eur J Nucl Med Mol Imaging 48:1570–1584, 2021. DOI
51. Teyateeti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Kaseb A, Odisio B, Ravizzini G, Surasi D, Macapinlac H, Kappadath SC. Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib. World J Gastroenterol 27(47):8166-8181, 2021. DOI
50. Kalevi K, Kappadath SC, Joensuu T, Macapinlac H. A retrospective comparative study of Sodium Fluoride (NaF-18)-PET/CT and Fluorocholine (F-18-CH) PET/CT in the evaluation of skeletal metastases in metastatic prostate cancer using volumetric 3-D radiomic analysis. Diagnostics 11(1):17, 2021. DOI
49. Kaseb AO, Kappadath SC, Lee SS, Raghav KP, Mohamed YI, Xiao L, Morris JS, Ohaji C, Avritscher R, Odisio BC, Kuban J, Abdelsalam ME, Chasen B, Elsayes KM, Elbanan M, Wolff RA, Yao JC, Mahvash A. A prospective phase II study of safety and efficacy of sorafenib followed by 90Y glass microspheres for patients with advanced or metastatic hepatocellular carcinoma. J Hepatocell Carcinoma 8:1129-1145, 2021. DOI
48. Kairemo K, Jessop AC, Vija AH, Ding X, Spence D, Kappadath SC, Macapinlac HA. A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid DualPhase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism. Diagnostics 11(11):2006, 2021. DOI
2020 (8)
47. Buettner S, Braat AJAT, Margonis GA, Brown DB, Taylor KB, Borgmann AJ, Kappadath SC, Mahvash A, IJzermans JNM, Weiss MJ, Lamarca A, Bell JK, Valle JW, Hagendoorn J, Koerkamp BG, Sze DY, Lam MGEH. Yttrium-90 Radioembolization in Intrahepatic. J Vasc Interv Radiol 20(30168):168-176, 2020. DOI
46. Teyateeti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Chasen B, Kaseb A, Kuban J, Odisio B, Murthy R, Macapinlac H, Kappadath SC. Survival outcomes for Y-90 transarterial radioembolization with and without sorafenib for unresectable hepatocellular carcinoma patients. J Hepatocell Carcinoma 7:117-131, 2020. DOI
45. Thomas MA, Mahvash A, Abdelsalam M, Kaseb AO, Kappadath SC. Planning dosimetry for 90Y radioembolization with glass microspheres: evaluating the fidelity of 99mTc-MAA and partition model predictions. Med Phys 47(10):5333-5342, 2020. DOI
44. Adrada, B, Moseley T, Kappadath SC, Whitman, GJ, Rauch GM. Molecular Breast Imaging-guided percutaneous biopsy of breast lesions: a new frontier on breast intervention. J of Breast Imaging 2(5):484-491, 2020. DOI
43. Popnoe DO, Chaan NS, Zhou S, Kaur H, Kang HC, Loyer EM, Kappadath SC, Jones AK. Comparison of virtual to true unenhanced abdominal computed tomography images acquired using rapid kV-switching dual energy imaging. PLOS One 15(9):e0238582, 2020. DOI
42. Abdelsalam M, Kappadath SC, Mahvash A. Blood flow diversion using the microvascular plug to avoid non target delivery of radioactive microspheres. Radiol Case Rep 15(10):2015-2017, 2020. DOI
41. Siman W, Mawlawi OR, Mourtada F, Kappadath SC. Systematic and random errors of PET-based 90Y 3D dose quantification. Med Phys 47(6):2441-2449, 2020. PubMed
40. Braat AJAT, Ahmadzadehfar H, Kappadath SC, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy. Cardiovasc Intervent Radiol 43(2):246-253, 2020. PubMed PMC
2019 (8)
39. Salem R, Padia SA, Lam M, Bell J, Chiesa C, Fowers K, Hamilton B, Herman J, Kappadath SC, Leung T, Portelance L, Sze D, Garin E. Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 46(8):1695-1704, 2019. PubMed
38. Lopez B, Mahvash A, Lam MGEH, Kappadath SC. Calculation of lung mean dose and quantification of error for 90Y-microsphere radioembolization using 99mTc-MAA SPECT/CT and diagnostic chest CT. Med Phys 46(9):3929-3940, 2019. PubMed
37. Popnoe DO, Ng CS, Zhou S, Kappadath SC, Pan T, Jones AK. Comparison of enhancement quantification from virtual unenhanced images to true unenhanced images in multiphase renal Dual‐Energy computed tomography: A phantom study. J Appl Clin Med Phys 20(8):171-179, 2019. PubMed PMC
36. Pan T, Einstein SA, Kappadath SC, Grogg KS, Lois Gomez C, Alessio AM, Hunter WC, El Fakhri G, Kinahan PE, Mawlawi OR. Performance evaluation of the 5-Ring GE Discovery MI PET/CT system using the national electrical manufacturers association NU 2-2012 Standard. Med Phys 46(7):3025-3033, 2019. PubMed PMC
35. Braat AJAT, Kappadath SC, Ahmadzadehfar H, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity. Cardiovasc Intervent Radiol 42(3):413-425, 2019. PubMed
34. Henry EC, Mawko G, Tonkopi E, Frampton J, Kehoe S, Boyd D, Abraham R, Gregoire M, O'Connell K, Kappadath SC, Syme A. Quantification of the inherent radiopacity of glass microspheres for precision dosimetry in yttrium-90 radioembolization. Biomed Phys Eng Express 5:055011, 2019. DOI
33. Vu T, Schellingerhout D, Guha-Thakurta N, Sun J, Wei SW, Kappadath SC, Perrier N, Kim EE, Rohren E, Chuang HH, Wong FC. Solitary parathyroid adenoma localization in Technetium Tc99m Sestamibi SPECT CT and multiphase multidetector 4CDT. AJNR Am J Neuroradiol 40(1):142-49, 2019. PubMed PMC
32. Siman W, Mikell JK, Mawlawi OR, Mourtada F, Kappadath SC. Dose volume histogram-based optimization of image reconstruction parameters for quantitative 90 Y-PET imaging. Med Phys 46(1):229-237, 2019. PubMed
2018 (4)
31. Bastiaannet R, Kappadath SC, Kunnen B, Braat AJAT, Lam MGEH, de Jong HWAM. The physics of radioembolization. EJNMMI Phys 5(1):22, 2018. PMC
30. Kappadath SC, Mikell J, Balagopal A, Baladandayuthapani V, Kaseb A, Mahvash A. Hepatocellular carcinoma tumor dose response following 90Y-radioembolization with glass microspheres using 90Y-SPECT/CT based voxel dosimetry. Int J Radiation Oncol Biol Phys 102(2):451-461, 2018. DOI
29. Pahlka RB, Kappadath SC, Mawlawi O. A Monte Carlo simulation of coincidence detection and imaging of gamma-ray cascades with a scintillation camera. Biomed Phys Eng Express 4:055012, 2018. DOI
28. Balagopal A, Kappadath SC. Characterization of 90Y-SPECT/CT self-calibration approaches on the quantification of voxel-level absorbed doses following 90Y-microsphere selective internal radiation therapy. Med Phys 45(2):875-83, 2018. e-Pub 12/2017. PubMed
2017 (4)
27. Siman W, Mawlawi O, Mikell JM, Mourtada F, Kappadath SC. Effects of image noise, respiratory motion, and motion compensation on 3D activity quantification in count-limited PET images. Phys Med Bio 62:448-464, 2017. PubMed
26. Bache ST, Kappadath SC. Quantitation of tumor uptake with molecular breast imaging. Med Phys 44(9):4593-4607, 2017. PubMed
25. Braat AJAT, Kappadath SC, Bruijnen RCG, van den Hoven AF, Mahvash A, de Jong HWAM, Lam MGEH. Adequate SIRT activity dose is as important as adequate chemotherapy dose. Lancet Oncol 18(11):e636, 2017. PubMed
24. Siman W, Kappadath SC. Comparison of step-and-shoot and continuous-bed-motion positron emission tomography modes of acquisition for limited-view organ scans. J Nucl Med Technol 45(4):290-296, 2017. PubMed PMC
2016 (3)
23. Mikell J, Mahvash A, Siman W, Baladandayuthapani V, Mourtada F, Kappadath SC. Selective internal radiation therapy with 90Y glass microspheres: biases and uncertainties in absorbed dose calculations between clinical dosimetry models. Int J Radiat Oncol Biol Phys 96(4):888-896, 2016. PubMed PMC
22. Siman W, Mikell J, Kappadath SC. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT. Med Phys 43(9):5093-5103, 2016. DOI
21. Mikell J, Kappadath SC, Wareing T, Erwin WD, Titt U, Mourtada F. Evaluation of a deterministic grid-based boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine. Phys Med Biol 61(12):4564-4582, 2016. PubMed
2015 (5)
20. Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90Y microsphere selective internal radiation therapy. EJNMMI Physics 2(16):16, 2015. PubMed PMC
19. Meier J, Kappadath SC. Characterization of the energy response and backscatter contribution for two electronic personal dosimeter models. J Appl Clin Med Phys 16(6):423-434, 2015. PubMed PMC
18. Wait JM, Cody D, Jones AK, Rong J, Baladandayuthapani V, Kappadath SC. Performance evaluation of material decomposition with rapid kVp-switching dual energy CT and implications for assessing bone mineral density. Am J Roentgenol 204(6):1234-1241, 2015. PubMed
17. Willowson KP, Tapner M, Kappadath SC, Bailey DL. A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: The QUEST Phantom Study. Eur J Nucl Med Mol Imaging 42:1202-1222, 2015. PubMed PMC
16. Siman W, Silosky M, Kappadath SC. A revised monitor source method for practical deadtime count loss compensation in clinical planar and SPECT studies. Phys Med Biol 60(3):1199-216, 2015. PubMed
2014 and Prior Years (15)
15. Hulme KW, Kappadath SC. Implications of CT noise and artifacts for quantitative (99m)Tc SPECT/CT imaging. Med Phys 41(4):042502, 2014. PubMed
14. Silosky M, Johnson V, Beasley C, Kappadath SC. Characterization of the count rate performance of modern gamma cameras. Med Phys 40(3):032502, 2013. PubMed PMC
13. Siman W, Kappadath SC. Performance characteristics of a new pixelated portable gamma camera. Med Phys 39(6):3435-3444, 2012. PubMed PMC
12. Hulme KW, Rong J, Chasen B, Chuang HH, Cody DD, Wong FC, Kappadath SC. A CT acquisition technique to generate images at various dose levels for prospective dose reduction studies. Am J Roentgenol 196(2):W144-51, 2011. PubMed
11. Mathieu KB, Kappadath SC, White RA, Atkinson EN, Cody DD. An empirical model of diagnostic x-ray attenuation under narrow-beam geometry. Med Phys 38(8):4546-4555, 2011. PubMed PMC
10. Kappadath SC. Effects of voxel size and iterative reconstruction parameters on the spatial resolution of 99mTc SPECT/CT. J Appl Clin Med Phys 12(4):3459, 2011. e-Pub 11/2011. PubMed PMC
9. Kappadath SC, Erwin WD, Wendt RE. A novel method to evaluate gamma camera rotational uniformity and sensitivity variation. Med Phys 36(6):1947-1955, 6/2009. PubMed PMC
8. Kappadath SC, Shaw CC. Dual-energy digital mammography: noise reduction techniques. Phys Med Bio 53:5421-43, 2008. PubMed PMC
7. Mawlawi O, Kappadath SC, Pan T, Macapinlac H. Factors affecting quantification in PET/CT imaging. Current Medical Imaging Reviews 4, 2008. DOI
6. Kappadath SC, Erwin WD, Wendt RE. Observed intercamera variability in clinically relevant performance characteristics for Siemens Symbia gamma cameras. J Appl Clin Med Phys 7(4), 2006. PubMed PMC
5. Lai CJ, Shaw CC, Whitman GJ, Johnston DA, Yang WT, Selinko V, Arribas E, Dogan B, Kappadath SC. Visibility of simulated microcalcifications-a hardcopy-based comparison of three mammographic systems. Med Phys 32(1):182-94, 2005. PubMed
4. Kappadath SC, Shaw CC. Dual-energy digital mammography for calcification imaging: scatter and nonuniformity corrections. Med Phys 32(11):3395-408, 2005. PubMed
3. Kappadath SC, Shaw CC. Quantitative evaluation of dual-energy digital mammography for calcification imaging. Phys Med Biol 49:2563-76, 2004. PubMed
2. Kappadath SC, Shaw CC. Dual-energy digital mammography: calibration and inverse-mapping techniques to estimate calcification thickness and glandular-tissue ratio. Med Phys 30(6):1110-7, 2003. PubMed
1. Lemacks MR, Kappadath SC, Shaw CC, Liu X, Whitman GJ. A dual-energy subtraction technique for microcalcification imaging in digital mammography: a signal-to-noise analysis. Med Phys 29(8):1739-51, 2002. PubMed