Selected Publications

Siman W, Mawlawi OR, Mourtada F, Kappadath SC.  Systematic and random errors of PET-based 90 Y 3D dose quantification. Med Phys:5. doi: 10.1002/mp.14117, 2020. PMID: 32135025.

Braat AJAT, Ahmadzadehfar H, Kappadath SC, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy. Cardiovasc  Intervent Radiol 43(2):246-253 doi: 10.1007/s00270-019-02350-2., 2/2020. PMID: 31646375.

Salem R, Padia SA, Lam M, Bell J, Chiesa C, Fowers K, Hamilton B, Herman J, Kappadath SC, Leung T, Portelance L, Sze D, Garin E. Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 46(8):1695-1704, 7/2019. e-Pub 5/2019. PMID: 31098749.

Lopez B, Mahvash A, Lam MGEH, Kappadath SC. Calculation of lung mean dose and quantification of error for 90Y-microsphere radioembolization using
99mTc-MAA SPECT/CT and diagnostic chest CT. Med Phys 46(9):3929-3940, 2019.  e-Pub 5/2019. PMID: 31063600.

Popnoe DO, Ng CS, Zhou S, Kappadath SC, Pan T, Jones AK. Comparison of enhancement quantification from virtual unenhanced images to true unenhanced images in multiphase renal Dual‐Energy computed tomography: A phantom study. J Appl Clin Med Phys 20(8):171-179, 2019.

Pan T, Einstein SA, Kappadath SC, Grogg KS, Lois Gomez C, Alessio AM, Hunter WC, El Fakhri G, Kinahan PE, Mawlawi OR. Performance evaluation of the 5-Ring GE Discovery MI PET/CT system using the national electrical manufacturers association NU 2-2012 Standard.  Med Phys 46(7):3025-3033, 2019. e-Pub 5/2019.  PMID: 31069816.

Braat AJAT, Kappadath SC, Ahmadzadehfar H, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity.  Cardiovasc Intervent Radiol 42(3):413-425, 3/2019. e-Pub 1/2019.  PMID: 30603975.

Henry EC, Mawko G, Tonkopi E, Frampton J, Kehoe S, Boyd D, Abraham R, Gregoire M, O'Connell K, Kappadath SC, Syme A. Quantification of the inherent radiopacity of glass microspheres for precision dosimetry in yttrium-90 radioembolization.  Biomed. Phys. Eng. Express:5:055011, 2019.

Vu T, Schellingerhout D, Guha-Thakurta N, Sun J, Wei SW, Kappadath SC, Perrier N, Kim EE, Rohren E, Chuang HH, Wong FC.  Solitary parathyroid adenoma localization in Technitium Tc99m Sestamibi SPECT CT and multiphase multidetector 4CDT. Am J  Neuroradiol 40:142-49, 2019. e-Pub 12/2018.

Siman W, Mikell JK, Mawlawi OR, Mourtada F, Kappadath SC. Dose volume histogram-based optimization of image reconstruction parameters for quantitative 90 Y-PET imaging. Med Phys 46(1):229-237, 2019. e-Pub 11/2018.  PMID: 30375655.

Bastiaannet R, Kappadath SC, Kunnen B, Braat AJAT, Lam MGEH, de Jong HWAM. The physics of radioembolization. EJNMMI Phys 5(1):22, 11/2018. e-Pub 11/2018.  PMCID: PMC6212377.

Kappadath SC, Mikell J, Balagopal A, Baladandayuthapani V, Kaseb A, Mahvash A. Hepatocellular carcinoma tumor dose response following 90Y-radioembolization with glass microspheres using 90Y-SPECT/CT based voxel dosimetry. Int J Radiation Oncol Biol Phys 102(2):451-461, 2018. e-Pub 6/2018.

Pahlka RB, Kappadath SC, Mawlawi O. A Monte Carlo simulation of coincidence detection and imaging of gamma-ray cascades with a scintillation camera. Biomed Phys Eng Express 4, 055012, https://doi.org/10.1088/2057-1976/aad572, 2018.

Balagopal A, Kappadath SC. Characterization of 90Y-SPECT/CT self-calibration approaches on the quantification of voxel-level absorbed doses following
90Y-microsphere selective internal radiation therapy. Med Phys 45(2):875-83, 2018. e-Pub 12/2017. PMID: 29172243.

Siman W, Mawlawi O, Mikell JM, Mourtada F, Kappadath SC. Effects of image noise, respiratory motion, and motion compensation on 3D activity quantification in count-limited PET images. Phys Med Bio 62:448-464, 2017. e-Pub 12/2016. PMID: 28000618.

Bache ST, Kappadath SC. Quantitation of tumor uptake with molecular breast imaging. Med Phys 44(9):4593-4607, 2017. e-Pub 7/2017. PMID: 28600857.

Braat AJAT, Kappadath SC, Bruijnen RCG, van den Hoven AF, Mahvash A, de Jong HWAM, Lam MGEH. Adequate SIRT activity dose is as important as adequate chemotherapy dose. Lancet Oncol 2017 Nov 18(11):e636. doi: 10.1016/S1470-2045(17)30811-2. e-Pub 10/2017.

Siman W, Kappadath SC. Comparison of step-and-shoot and continuous-bed-motion positron emission tomography modes of acquisition for limited-view organ scans. J Nucl Med Technol 45(4):290-296, 2017. e-Pub 10/2017.

A Balagopal, Kappadath SC. Characterization of 90Y-SPECT/CT self-calibration approaches on the quantification of voxel-level absorbed doses following 90Y-microsphere selective internal radiation therapy. Med Phys 45(2):875-83, 2018. e-Pub 11/2017.

Mikell J, Mahvash A, Siman W, Baladandayuthapani V, Mourtada F, Kappadath SC. Selective internal radiation therapy with 90Y glass microspheres: biases and uncertainties in absorbed dose calculations between clinical dosimetry models. Int J Radiation Oncol Biol Phys, 2016.

Siman W, Mikell J, Kappadath SC. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT. Med Phys 43(9): 5093-5103, 2016.

Mikell J, Kappadath SC, Wareing T, Erwin WD, Titt U, Mourtada F. Evaluation of a deterministic grid-based boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine. Phys Med Biol 61: 4564-4582, 2016.

Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90Y microsphere selective internal radiation therapy. EJNMMI Physics 2(16):16, 2015.

Meier J, Kappadath SC. Characterization of the energy response and backscatter contribution for two electronic personal dosimeter models. J Appl Clin Med Phys 16(6):423-434, 2015.

Wait JM, Cody D, Jones AK, Rong J, Baladandayuthapani V, Kappadath SC. Performance evaluation of material decomposition with rapid kVp-switching dual energy CT and implications for assessing bone mineral density. Am J Roentgenol 204(6):1234-1241, 6/2015.

Willowson KP, Tapner M, Kappadath SC, Bailey DL. A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: The QUEST Phantom Study. Eur J Nucl Med Mol Imaging 42:1202-1222, 5/2015.

Siman W, Silosky M, Kappadath SC. A revised monitor source method for practical deadtime count loss compensation in clinical planar and SPECT studies. Phys Med Biol 60(3):1199-216, 2/2015. e-Pub 1/2015. PMID: 25591740.

Hulme KW, Kappadath SC. Implications of CT noise and artifacts for quantitative (99m)Tc SPECT/CT imaging. Med Phys 41(4):042502, 4/2014.

Silosky M, Johnson V, Beasley C, Kappadath SC. Characterization of the count rate performance of modern gamma cameras. Med Phys 40(3):032502, 3/2013. PMCID: PMC3829891.

Siman W, Kappadath SC. Performance characteristics of a new pixelated portable gamma camera. Med Phys 39(6):3435-3444, 6/2012. PMCID: PMC3829890.

Hulme KW, Rong J, Chasen B, Chuang HH, Cody DD, Wong FC, Kappadath SC. A CT acquisition technique to generate images at various dose levels for prospective dose reduction studies. AJR Am J Roentgenol 196(2):W144-51, 2/2011.

Mathieu KB, Kappadath SC, White RA, Atkinson EN, Cody DD. An empirical model of diagnostic x-ray attenuation under narrow-beam geometry. Med Phys 38(8):4546-4555, 8/2011. PMCID: PMC3155576.

Kappadath SC. Effects of voxel size and iterative reconstruction parameters on the spatial resolution of 99mTc SPECT/CT. J Appl Clin Med Phys 12(4):3459, 2011. e-Pub 11/2011.

Kappadath SC, Erwin WD, Wendt RE. A novel method to evaluate gamma camera rotational uniformity and sensitivity variation. Med Phys 36(6):1947-1955, 6/2009.

Kappadath SC, Shaw CC. Dual-energy digital mammography: noise reduction techniques. Phys Med Bio 53:5421-43, 2008.

Mawlawi O, Kappadath SC, Pan T, Macapinlac H. Factors affecting quantification in PET/CT imaging. Current Medical Imaging Reviews 4, 2008.

Kappadath SC, Erwin WD, Wendt RE. Observed intercamera variability in clinically relevant performance characteristics for Siemens Symbia gamma cameras. Journal of Applied Clinical Medical Physics 7(4), 2006.

Lai CJ, Shaw CC, Whitman GJ, Johnston DA, Yang WT, Selinko V, Arribas E, Dogan B, Kappadath SC. Visibility of simulated microcalcifications-a hardcopy-based comparison of three mammographic systems. Med Phys 32(1):182-94, 2005.

Kappadath SC, Shaw CC. Dual-energy digital mammography for calcification imaging: scatter and nonuniformity corrections. Med Phys 32(11):3395-408, 2005.

Kappadath SC, Shaw CC. Quantitative evaluation of dual-energy digital mammography for calcification imaging. Phys Med Biol 49:2563-76, 2004

Kappadath SC, Shaw CC. Dual-energy digital mammography: calibration and inverse-mapping techniques to estimate calcification thickness and glandular-tissue ratio. Med Phys 30(6):1110-7, 2003.

Lemacks MR, Kappadath SC, Shaw CC, Liu X, Whitman GJ. A dual-energy subtraction technique for microcalcification imaging in digital mammography: a signal-to-noise analysis. Med Phys 29(8):1739-51, 2002.