- Breast Cancer
- DNA Damage Response
The Piwnica-Worms Laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer. A major effort is directed towards elucidating the contribution made by heterogeneity (genomic, phenotypic, spatial and compositional) in both the tumor and its microenvironment to cancer progression, metastasis and resistance to therapy. A second major effort is understanding how fasting and certain diets protect stem cells and promote organismal survival in the presence of lethal forms of DNA damage.