Areas of Research
- Radiation Therapy Research
- Imaging Research
- Oral Cancer Research
- Throat Cancer Research
- Survivorship Research
- Symptom Research
- Cancer Care Innovation Research
- HPV Research
The Fuller Laboratory aims to advance care and reduce side effects for head and neck cancer patients by improving radiotherapy using imaging and informatics tools.
Research in the Fuller Lab focuses on:
- Standardizing data, image, treatment and informatic process.
- Adaptive and personalized treatments.
- Big data and statistical innovation.
- Multi-modal quantitative integrations.
Our lab's main research focus is directed towards the precise integration of advanced bio-imaging in radiation therapy, which is essential for improving survival and oncologic outcomes for cancer patients and is currently an unmet healthcare need. Our long-term goal is to develop novel bio-imaging based platforms that allow for biologically-modulated adaptive radiation therapy for future personalized radiation therapy applications. This involves the integration of multimodality imaging methodologies, biomarkers identification and characterization, imaging-guided dose-response assessment for tumor and normal tissues, multimodality image registration, adaptive therapy planning, patterns of failure characterization and oncologic outcomes correlation.
Pezzi T, Schwartz D, Mohamed A, et al. Barriers to combined modality therapy for limited-stage small cell lung cancer. JAMA oncology. 1/2018.
Kamal M, Rosenthal D, Volpe S, et al. Patient Reported Dry Mouth: Instrument Comparison and Model Performance for Correlation with Quality of Life in Head and Neck Cancer Survivors. Radiotherapy and Oncology. 12/2017.
Mohamed AS, Hansen C, Weygand J, Ding Y, Frank SJ, Hwang K, Hazle J, Fuller CD, Wang J. Prospective analysis of in vivo landmark point-based MRI geometric distortion in head and neck cancer patients scanned in immobilized radiation treatment position: Results of a prospective quality assurance protocol. Clinical and Translational Radiation Oncology. 12/2017.
Ger R, Mohamed AS, Awan MJ, et al. Joint Head and Neck Radiotherapy-MRI Development Cooperative. A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations. Scientific Reports. 9/2017.
Eraj S, Kamal M, Rock C, Mohamed A, Sminth B, Smith J, et al. Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: Cross-sectional assessment of a prospective symptom survey in patients ≥65 years old. Radiation Oncology. 8/2017.
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
Major goals: 1) To establish DCE-MRI as an effective clinical outcome measure to identify acute and chronic changes in mandibular bone physiology in cancer patients undergoing definitive irradiation; and 2) To evaluate the use of DCE-MRI parameters to monitor ORN response to treatment.
P50CA097007-10 (Myers, PI) (Fuller)
Head and Neck SPORE Developmental
Bayesian Phase II Trial of MR-Guided Adaptive Radiotherapy
Major goals: To execute a multi-site Phase II trial of dose-declation based on anatomic MRI responses during radiotherapy for human papilloma virus positive head and neck cancers, using an MRI-Linear accelerator for daily dose modification and toxicity reduction.
NSF 1557559 (Fuller)
National Science Foundation (NSF)
QuBBD: Collaborative Research: SMART Spatial-nonspatial Multidimensional Adaptive Radiotherapy Treatment
Major goals: To develop, validate and implement the requisite methodological and technical infrastructure to execute an image-guided adaptive treatment regime for neck/head cancer patients using a Big Data approaches.
1R01CA214825-01 (Fuller, co-PI)
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer Treatment
Major goals: To develop and deploy a validated precision model of patient-specific outcomes for head and neck cancers based on demographics, toxicity, and complex imaging data.
Andrew Sabin Family Fellows Program (Fuller)
MD Anderson Cancer Center
Novel Methodological Approaches for Integrating Imaging Informatics and Clinical "Big Data" in Head and Neck Cancers
Major goals: To develop computational methodology that will support the construction of a sophisticated precision model of patient-specific outcomes for head and neck cancer therapy.
R01CA218148 (Fuller, co-PI)
imaging Radiation-Associated Dysphagia (iRAD)
Major goals: To reduce toxicity of head and neck radiotherapy through advanced imaging
1R01CA225190-01 (Fuller, co-PI)
QUBBD: Precision E–Radiomics for Dynamic Big Head & Neck Cancer Data
Major goals: To design a novel approach for adaptive radiotherapy treatment of head and neck cancer.