The primary interest of our research group is to delineate the molecular mechanisms through which diabetic nephropathy progresses. We are also studying the molecular mechanisms by which cisplatin induces nephrotoxicity.
Mitochondrial Dysfunction: We want to understand the biological functions of mitochondrial dynamics and how changes in mitochondrial morphology contribute to the pathogenesis of diabetic kidney disease (Wang W et al. Cell Met. 2012 15:186-200).
MicroRNA and Long-non coding RNAs: Our laboratory has been on the forefront of identifying multiple miRNAs and their downstream effectors in the kidney. We have recently published novel observations on the potential effects of miRNAs in diabetic nephropahy (Long J. et al: J. Biol. Chem. 2010, 285:23457–23465; and Long J. et al: J. Biol. Chem. 2011, 286: 11837 - 11848). These collective efforts have significantly accelerated the process of assessing the role of miRNAs in the pathobiology of diabetic nephropathy.
Cisplatin-induced nephrotoxicity: The underlying molecular mechanisms of cisplatin-induced nephrotoxicity are unknown. Understanding these mechanisms provide important insights for designing more efficient platinum-based drugs.