The Danesh Laboratory mainly studies mitochondria, which are essential organelles inside cells, and their dysregulation in kidney pathologies.
Mitochondrial medicine has experienced significant progress in recent years and is expected to grow significantly in the near future, yielding many opportunities to translate novel bench discoveries into clinical medicine. Multiple lines of evidence have linked mitochondrial dysfunction to metabolic diseases, including diabetic nephropathy.
Given the multi-faceted roles of mitochondria, the overarching hypothesis in the Danesh lab is that these amazing organelles are involved in a myriad of biological processes and pathways that ultimately contribute to progression of diabetic kidney disease. A major focus of our work, therefore, is to understand the role and nature of mitochondrial dysfunction in diabetic kidney disease. In doing so, we continue to elucidate novel ways that mitochondria contribute to progression of kidney diseases.