Finite element based inverse problems techniques are seen capable of accurately reproducing the selective heating of the nanoparticle mediated photothermal therapies. The in-vivo recovered spatial map of optical parameters may also be used as a quantitative marker of the nanoparticle uptake.
Model Assisted Monitoring
Non-damaging laser test pulses may simultaneously be used for patient safety to verify the application position as well as used for calibration the parabolic bioheat transfer model on a patient specific basis.
Deformation Based Morphometry - Large Deformation Registration
A multi-resolution approach is applied within a pipeline of affine and diffeomorphic registration to achieve a dense large deformation mapping.
Imaging to Mesh Generation Pipeline
A schematic of the Imaging-to-FEM mesh pipeline is shown. The hexahedral mesh shown has distinct regions for the prostate and laser.